Disease on EC 3.5.4.37 - double-stranded RNA adenine deaminase
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Acute Lung Injury
ADAR1 p150 IN ALVEOLAR MACROPHAGE IS INVOLVED IN LPS-INDUCED LUNG INJURY.
Adenocarcinoma
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Adenocarcinoma of Lung
Decrease in ADAR1 expression by exposure to cigarette smoke enhances susceptibility to oxidative stress.
Adenocarcinoma of Lung
Ribonuclease L mediates the cell-lethal phenotype of the double-stranded RNA editing enzyme ADAR1 in a human cell line.
Amyotrophic Lateral Sclerosis
A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.
Amyotrophic Lateral Sclerosis
Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUS(P525L) mutation.
Amyotrophic Lateral Sclerosis
Determination of editors at the novel A-to-I editing positions.
Anemia
Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity.
Anemia
Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys.
Anhedonia
Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine.
Aortic Aneurysm
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Astrocytoma
ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas.
Astrocytoma
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.
Astrocytoma
Down-regulation of RNA Editing in Pediatric Astrocytomas: ADAR2 EDITING ACTIVITY INHIBITS CELL MIGRATION AND PROLIFERATION.
Atherosclerosis
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Autoimmune Diseases
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells.
Autoimmune Diseases
Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.
Autoimmune Diseases
Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development.
Autoimmune Diseases
LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways.
Autoimmune Diseases
Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes.
Blast Crisis
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.
Blast Crisis
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.
Borna Disease
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Brain Diseases
ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep.
Brain Diseases
Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy.
Brain Diseases
Phenotypic Variation in Aicardi-Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release.
Breast Neoplasms
8-Chloro-Adenosine Inhibits Proliferation of MDA-MB-231 and SK-BR-3 Breast Cancer Cells by Regulating ADAR1/p53 Signaling Pathway.
Breast Neoplasms
A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer.
Breast Neoplasms
ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response.
Breast Neoplasms
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Breast Neoplasms
Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis.
Breast Neoplasms
RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA.
Breast Neoplasms
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
Breast Neoplasms
Targeting DDX3X Triggers Antitumor Immunity via a dsRNA-Mediated Tumor-Intrinsic Type I Interferon Response.
Carcinogenesis
ADAR1-mediated 3' UTR editing and expression control of antiapoptosis genes fine-tunes cellular apoptosis response.
Carcinogenesis
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Carcinogenesis
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Carcinogenesis
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
Carcinogenesis
Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.
Carcinogenesis
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non-small cell lung cancer cells to anlotinib by regulating CX3CR1-fractalkine expression.
Carcinogenesis
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis.
Carcinoma
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Carcinoma
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
Carcinoma
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.
Carcinoma
Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma.
Carcinoma
RNA editing is induced by type I interferon in esophageal squamous cell carcinoma.
Carcinoma, Hepatocellular
ADAR1 affects HCV infection by modulating innate immune response.
Carcinoma, Hepatocellular
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
Carcinoma, Hepatocellular
ADAR2-mediated editing of miR-214 and miR-122 precursor and antisense RNA transcripts in liver cancers.
Carcinoma, Hepatocellular
CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients.
Carcinoma, Squamous Cell
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Carcinoma, Squamous Cell
Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence.
Carcinoma, Squamous Cell
RNA editing is induced by type I interferon in esophageal squamous cell carcinoma.
Cardiomyopathy, Dilated
Modulation of ADAR mRNA expression in patients with congenital heart defects.
Cardiotoxicity
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Carotid Artery Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Cervical Intraepithelial Neoplasia
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Chordoma
Overexpression of adenosine deaminase acting on RNA 1 in chordoma tissues is associated with chordoma pathogenesis by reducing miR?125a and miR?10a expression.
Colitis
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.
Colorectal Neoplasms
Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.
Colorectal Neoplasms
LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer.
Coronary Artery Disease
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
COVID-19
RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification.
Dengue
MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression.
Dengue
The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.
Dermatomyositis
Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1.
double-stranded rna adenine deaminase deficiency
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
double-stranded rna adenine deaminase deficiency
ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
double-stranded rna adenine deaminase deficiency
ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway.
double-stranded rna adenine deaminase deficiency
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
double-stranded rna adenine deaminase deficiency
ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner.
double-stranded rna adenine deaminase deficiency
ADAR1 is vital for B cell lineage development in the mouse bone marrow.
double-stranded rna adenine deaminase deficiency
ADAR1, inosine and the immune sensing system: distinguishing self from non-self.
double-stranded rna adenine deaminase deficiency
c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.
double-stranded rna adenine deaminase deficiency
Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.
double-stranded rna adenine deaminase deficiency
Deficient RNA-editing enzyme ADAR2 in an amyotrophic lateral sclerosis patient with a FUS(P525L) mutation.
double-stranded rna adenine deaminase deficiency
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes.
double-stranded rna adenine deaminase deficiency
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.
double-stranded rna adenine deaminase deficiency
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
double-stranded rna adenine deaminase deficiency
RNA editing enzyme adenosine deaminases acting on RNA 1 deficiency increases the sensitivity of non-small cell lung cancer cells to anlotinib by regulating CX3CR1-fractalkine expression.
double-stranded rna adenine deaminase deficiency
RNA editing of the Q/R site of GluA2 in different cultured cell lines that constitutively express different levels of RNA editing enzyme ADAR2.
double-stranded rna adenine deaminase deficiency
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.
double-stranded rna adenine deaminase deficiency
Specificity of ADAR-mediated RNA editing in newly identified targets.
Down Syndrome
Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains.
Dystonia
Dystonia, mental deterioration, and dyschromatosis symmetrica hereditaria in a family with ADAR1 mutation.
Encephalitis, Viral
Dyschromatosis symmetrica hereditaria by ADAR1 mutations and viral encephalitis: a hidden link?
Endometriosis
Aberrant Overexpression of RNA-Editing Enzyme ADAR1 Promotes the Progression of Endometriosis.
Epilepsy
Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Epilepsy
Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
Epilepsy
Novel Etiological and Therapeutic Strategies for Neurodiseases: RNA Editing Enzyme Abnormality in Sporadic Amyotrophic Lateral Sclerosis.
Equine Infectious Anemia
Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity.
Equine Infectious Anemia
Double-stranded-RNA-specific adenosine deaminase 1 (ADAR1) is proposed to contribute to the adaptation of equine infectious anemia virus from horses to donkeys.
Esophageal Neoplasms
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Esophageal Squamous Cell Carcinoma
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
RNA editing is induced by type I interferon in esophageal squamous cell carcinoma.
Ganglion Cysts
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Glaucoma
Down-Regulation of the RNA Editing Enzyme ADAR2 Contributes to RGC Death in a Mouse Model of Glaucoma.
Glioblastoma
ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism.
Glioblastoma
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.
Glioblastoma
Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.
Glioblastoma
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
Glioma
Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma.
Glioma
Abnormal expression of an ADAR2 alternative splicing variant in gliomas downregulates adenosine-to-inosine RNA editing.
Glioma
Astrocytic insulin-like growth factor-1 prevents excitotoxic downregulation of adenosine deaminase acting on RNA in calcium dynamics.
Glioma
Isolation and characterization of intranuclear ribonucleoprotein complexes associated with double-stranded RNA adenosine deaminase from brain cells: implications for RNA-editing and hypermutation of viral RNA in the CNS.
Glioma
PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas.
Heart Defects, Congenital
Modulation of ADAR mRNA expression in patients with congenital heart defects.
Heart Diseases
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Hemangioma
Two novel ADAR1 gene mutations in two patients with dyschromatosis symmetrical hereditaria from birth.
Hepatitis
Crystallization and X-ray diffraction analysis of the Trp/amber editing site of hepatitis delta virus (+)RNA: a case of rational design.
Hepatitis
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Hepatitis
Effects of conserved RNA secondary structures on hepatitis delta virus genotype I RNA editing, replication, and virus production.
Hepatitis
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
Hepatitis
Hepatitis delta virus minimal substrates competent for editing by ADAR1 and ADAR2.
Hepatitis
Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2.
Hepatitis
Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression.
Hepatitis
Replicating hepatitis delta virus RNA is edited in the nucleus by the small form of ADAR1.
Hepatitis
The fraction of RNA that folds into the correct branched secondary structure determines hepatitis delta virus type 3 RNA editing levels.
Hepatitis B
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.
Hepatitis B, Chronic
Polymorphisms in ADAR1 gene affect response to interferon alpha based therapy for chronic hepatitis B in Han Chinese.
Hepatitis C
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.
Hepatitis C
New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1.
Hirschsprung Disease
Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.
HIV Infections
ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.
Hyperalgesia
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Hyperglycemia
Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.
Hypersensitivity
IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in 1q21(amp) multiple myeloma.
Hypersensitivity
Requirement of the RNA editing enzyme ADAR2 for normal physiology in mice.
Idiopathic Pulmonary Fibrosis
The Role of ADAR1 and ADAR2 in the Regulation of miRNA-21 in Idiopathic Pulmonary Fibrosis.
Immune System Diseases
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.
Infections
A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses.
Infections
A survey on cellular RNA editing activity in response to Candida albicans infections.
Infections
A-to-I editing of Malacoherpesviridae RNAs supports the antiviral role of ADAR1 in mollusks.
Infections
ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element.
Infections
ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity.
Infections
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Infections
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus.
Infections
Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication.
Infections
Adenosine deaminase acting on RNA-1 (ADAR1) inhibits hepatitis B virus (HBV) replication by enhancing microRNA-122 processing.
Infections
Cloning and expression of Malabar grouper (Epinephelus malabaricus) ADAR1 gene in response to immune stimulants and nervous necrosis virus.
Infections
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Infections
Editing of Cellular Self-RNAs by Adenosine Deaminase ADAR1 Suppresses Innate Immune Stress Responses.
Infections
Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing.
Infections
Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2.
Infections
Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek's disease virus.
Infections
Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression.
Infections
Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.
Infections
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.
Infections
RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis.
Infections
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.
Influenza, Human
A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses.
Influenza, Human
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Influenza, Human
Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines.
Influenza, Human
The interactomes of influenza virus NS1 and NS2 proteins identify new host factors and provide insights for ADAR1 playing a supportive role in virus replication.
Influenza, Human
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Insulin Resistance
ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
Intellectual Disability
Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Leukemia
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice.
Leukemia, Myeloid, Acute
ADAR1 may be involved in the proliferation of acute myeloid leukemia cells via regulation of the Wnt pathway.
Leukemia, Myeloid, Acute
[Effect of ADAR1 on the development of MLL-AF9 induced murine AML].
Leukemia, T-Cell
Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1.
Leukocytosis
Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice.
Liver Cirrhosis
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.
Liver Cirrhosis
ADAR1 polymorphisms are related to severity of liver fibrosis in HIV/HCV-coinfected patients.
Liver Diseases
ADAR1 polymorphisms are related to severity of liver fibrosis in HIV/HCV-coinfected patients.
Liver Neoplasms
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Liver Neoplasms
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
Lung Injury
Endothelial cell-specific deficiency of the adenosine deaminase ADAR1 aggravates LPS-induced lung injury in mice via an MDA5-independent pathway.
Lung Neoplasms
ADARs and editing: The role of A-to-I RNA modification in cancer progression.
Lung Neoplasms
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
Lung Neoplasms
Identification of novel deregulated RNA metabolism-related genes in non-small cell lung cancer.
Lupus Erythematosus, Systemic
Altered editing in RNA editing adenosine deaminase ADAR2 gene transcripts of systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1.
Lymphatic Metastasis
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
Lymphatic Metastasis
Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.
Marek Disease
Hyperediting by ADAR1 of a new herpesvirus lncRNA during the lytic phase of the oncogenic Marek's disease virus.
Measles
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus.
Measles
Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines.
Measles
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
Measles
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.
Measles
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.
Melanoma
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.
Melanoma
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.
Melanoma
ADAR1 regulates melanoma cell invasiveness by controlling beta3-integrin via microRNA-30 family members.
Melanoma
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity.
Melanoma
ADAR1p150 regulates the biosynthesis and function of miRNA-149* in human melanoma.
Melanoma
Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex.
Melanoma
Endothelial cell-specific deficiency of the adenosine deaminase ADAR1 aggravates LPS-induced lung injury in mice via an MDA5-independent pathway.
Melanoma
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
Melanoma
RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.
Mesothelioma
ADAR2 Regulates Malignant Behaviour of Mesothelioma Cells Independent of RNA-editing Activity.
Microcephaly
Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures.
Microcephaly
Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
Mouth Neoplasms
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
Movement Disorders
Dystonia, mental deterioration, and dyschromatosis symmetrica hereditaria in a family with ADAR1 mutation.
Movement Disorders
Movement disorders in ADAR1 disease: Insights from a comprehensive cohort.
Muscular Diseases
Modulation of ADAR mRNA expression in patients with congenital heart defects.
Myocardial Infarction
ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity.
Myocarditis
Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.
Neoplasm Metastasis
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
Neoplasm Metastasis
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
Neoplasm Metastasis
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
Neoplasm Metastasis
CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing.
Neoplasm Metastasis
Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.
Neoplasm Metastasis
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
Neoplasm Metastasis
RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer.
Neoplasms
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.
Neoplasms
A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme.
Neoplasms
A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression.
Neoplasms
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
Neoplasms
Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.
Neoplasms
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
Neoplasms
ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism.
Neoplasms
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.
Neoplasms
ADAR1 is involved in the regulation of reprogramming human fibroblasts to induced pluripotent stem cells.
Neoplasms
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
Neoplasms
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Neoplasms
ADAR1 p110 Enhances Adhesion of Tumor Cells to Extracellular Matrix in Hepatocellular Carcinoma via Up-Regulating ITGA2 Expression.
Neoplasms
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
Neoplasms
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells.
Neoplasms
ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress.
Neoplasms
ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.
Neoplasms
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis.
Neoplasms
ADAR2 editing activity in newly diagnosed versus relapsed pediatric high-grade astrocytomas.
Neoplasms
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma.
Neoplasms
ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis.
Neoplasms
Adenosine Deaminase That Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma.
Neoplasms
Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma.
Neoplasms
Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma.
Neoplasms
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.
Neoplasms
Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition.
Neoplasms
AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer.
Neoplasms
CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients.
Neoplasms
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.
Neoplasms
Down-regulation of RNA Editing in Pediatric Astrocytomas: ADAR2 EDITING ACTIVITY INHIBITS CELL MIGRATION AND PROLIFERATION.
Neoplasms
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Neoplasms
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.
Neoplasms
High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome.
Neoplasms
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells.
Neoplasms
Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis.
Neoplasms
Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis.
Neoplasms
Metabolomic and Lipidomic Profiling Identifies The Role of the RNA Editing Pathway in Endometrial Carcinogenesis.
Neoplasms
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma.
Neoplasms
Overexpression of ADAR1 into the cytoplasm correlates with a better prognosis of patients with oral squamous cells carcinoma.
Neoplasms
Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis.
Neoplasms
RNA Editing by ADAR Adenosine Deaminases: From Molecular Plasticity of Neural Proteins to the Mechanisms of Human Cancer.
Neoplasms
RNA editing mediates the functional switch of COPA in a novel mechanism of hepatocarcinogenesis.
Neoplasms
Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries.
Neoplasms
The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.
Neoplasms
Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation.
Nervous System Diseases
Dyschromatosis symmetrica hereditaria associated with neurological disorders.
Neuralgia
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Obesity
ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice.
Obesity
Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.
Obesity
Hyperphagia-mediated obesity in transgenic mice misexpressing the RNA-editing enzyme ADAR2.
Pancreatic Neoplasms
The aberrant expression of ADAR1 promotes resistance to BET inhibitors in pancreatic cancer by stabilizing c-Myc.
Papillomavirus Infections
ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals.
Paralysis
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.
Paralysis
Adenosine-to-inosine genetic recoding is required in the adult-stage nervous system for coordinated behavior in Drosophila.
Peripheral Nerve Injuries
RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury.
Persistent Infection
ADAR2 Is Involved in Self and Nonself Recognition of Borna Disease Virus Genomic RNA in the Nucleus.
Persistent Infection
Characterization of the 5'-flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter.
Persistent Infection
Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes.
Pigmentation Disorders
Decoupling expression and editing preferences of ADAR1 p150 and p110 isoforms.
Polyomavirus Infections
Host Response to Polyomavirus Infection Is Modulated by RNA Adenosine Deaminase ADAR1 but Not by ADAR2.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[ADAR1 Knockout Inhibits Notch1-induced T-ALL in Mice].
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Expression of ADAR1 Isoforms in Murine Acute T-ALL Leukemia Model.]
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
[ADAR1 Knockout Inhibits Notch1-induced T-ALL in Mice].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
[Expression of ADAR1 Isoforms in Murine Acute T-ALL Leukemia Model.]
Psoriasis
Novel ADAR1 mutations in three cases of psoriasis coexisting with dyschromatosis symmetrica hereditaria.
Salmonella Infections
Analysis of A to I editing of miRNA in macrophages exposed to Salmonella.
Seizures
ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.
Seizures
Adenosine-to-inosine genetic recoding is required in the adult-stage nervous system for coordinated behavior in Drosophila.
Seizures
Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.
Sepsis
ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis.
Sepsis
ADAR1 is targeted by miR-143 to regulate IL-1?-induced endothelial activation through the NF?B pathway.
Sepsis
ADAR1 prevents small intestinal injury from inflammation in a murine model of sepsis.
Sepsis
Endothelial cell-specific deficiency of the adenosine deaminase ADAR1 aggravates LPS-induced lung injury in mice via an MDA5-independent pathway.
Skin Diseases
Five novel mutations in the ADAR1 gene associated with dyschromatosis symmetrica hereditaria.
Skin Diseases
Two novel mutations and evidence for haploinsufficiency of the ADAR gene in dyschromatosis symmetrica hereditaria.
Spasm
Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.
Spinal Cord Injuries
Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.
Squamous Cell Carcinoma of Head and Neck
ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation.
Stomach Neoplasms
Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling.
Stomach Neoplasms
ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation.
Stomach Neoplasms
Combinatory RNA-Sequencing Analyses Reveal a Dual Mode of Gene Regulation by ADAR1 in Gastric Cancer.
Stomach Neoplasms
Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer.
Stupor
Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster.
Teratocarcinoma
Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons.
Thyroid Neoplasms
ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.
Thyroid Neoplasms
An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.
Tremor
A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity.
Triple Negative Breast Neoplasms
ADAR1 expression is associated with tumour-infiltrating lymphocytes in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Correction to: Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Triple Negative Breast Neoplasms
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer.
Uterine Cervical Neoplasms
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
Vascular Diseases
Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease.
Vascular Diseases
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation.
Vesicular Stomatitis
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Vesicular Stomatitis
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
Vesicular Stomatitis
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
Virus Diseases
ADAR1 function affects HPV replication and is associated to recurrent human papillomavirus-induced dysplasia in HIV coinfected individuals.
Virus Diseases
ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication.
Virus Diseases
ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms.
Virus Diseases
ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury.
Virus Diseases
ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis.
Virus Diseases
Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus.
Virus Diseases
Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication.
Virus Diseases
Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs.
Virus Diseases
Double-stranded RNA adenosine deaminase activity during measles virus infection.
Virus Diseases
Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection.
Virus Diseases
Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection.
Virus Diseases
Enhancement of Replication of RNA Viruses by ADAR1 via RNA Editing and Inhibition of RNA-Activated Protein Kinase.
Virus Diseases
Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases.
Virus Diseases
Janus effects of ADAR1 on CVB3-induced viral myocarditis at different infection stages.
Virus Diseases
Reovirus-mediated induction of ADAR1 (p150) minimally alters RNA editing patterns in discrete brain regions.
Virus Diseases
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment.
Virus Diseases
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR.
Virus Diseases
The p150 Isoform of ADAR1 Blocks Sustained RLR signaling and Apoptosis during Influenza Virus Infection.
Virus Diseases
Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon.
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