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acetyl-methionine + H2O
methionine
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
N2-acetyl-L-lysine + H2O
L-lysine + acetate
N2-benzoyl-L-lysine + H2O
L-lysine + benzoate
N4-acetyl-L-diaminobutyric acid + H2O
L-diaminobutyrate + acetate
-
-
-
-
?
N5-nicotinyl-L-ornithine + H2O
L-ornithine + nicotinate
N5-propionyl-L-ornithine + H2O
L-ornithine + propionate
N6-acetyl-L-lysine + H2O
L-lysine + acetate
N6-acetyl-ornithine + H2O
L-ornithine + acetate
N6-acyl-L-lysine + H2O
a carboxylate + L-lysine
the enzyme specifically catalyzes hydrolysis of the epsilon-amide bond in various Nepsilon-acyl-L-lysines
-
-
?
N6-acyl-L-lysine + H2O
L-lysine + carboxylic acid
-
-
-
-
?
N6-alpha-naphthoyl-L-lysine + H2O
L-lysine + 1-naphthol
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
N6-butyryl-L-lysine + H2O
L-lysine + butanoate
-
-
-
-
?
N6-caproyl-L-lysine + H2O
L-lysine + n-hexanoate
-
-
-
-
?
N6-caprylyl-L-lysine + H2O
L-lysine + caprylic acid
-
-
-
-
?
N6-carbobenzoxy-L-lysine + H2O
L-lysine + benzoate
N6-chloroacetyl-L-lysine + H2O
L-lysine + chloroacetate
N6-chloroacetyl-ornithine + H2O
L-ornithine + chloroacetate
N6-cyclohexanecarboxyl-L-lysine + H2O
L-lysine + cyclohexanecarboxylate
-
-
-
-
?
N6-dichloroacetyl-L-lysine + H2O
L-lysine + dichloroacetate
-
-
-
-
?
N6-formyl-L-lysine + H2O
L-lysine + formate
N6-glycyl-L-lysine + H2O
L-lysine + glycine
-
-
-
-
?
N6-iodoacetyl-L-lysine + H2O
L-lysine + iodoacetate
-
-
-
-
?
N6-isobutyryl-L-lysine + H2O
L-lysine + isobutyrate
-
-
-
-
?
N6-m-nitrobenzoyl-L-lysine + H2O
L-lysine + 3-nitrobenzoate
-
-
-
-
?
N6-metacrylyl-L-lysine + H2O
L-lysine + ?
-
-
-
-
?
N6-nicotinyl-L-Lysine + H2O
L-lysine + nicotinate
N6-p-nitrobenzoyl-L-lysine + H2O
L-lysine + 4-nitrobenzoate
-
-
-
-
?
N6-phenylacetyl-L-lysine + H2O
L-lysine + phenylacetate
-
-
-
-
?
N6-propionyl-lysine + H2O
L-lysine + propionate
N6-propionyl-ornithine + H2O
L-ornithine + propionate
N6-trichloroacetyl-L-lysine + H2O
L-lysine + trichloroacetate
-
-
-
-
?
zeta-N-acetyl-DL-homolysine + H2O
?
-
-
-
-
?
additional information
?
-
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
Mushroom
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
epsilon-N-acyl-L-lysine + H2O
?
-
-
-
-
?
N2-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
N2-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
N2-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N2-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N2-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N2-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N5-nicotinyl-L-ornithine + H2O
L-ornithine + nicotinate
-
-
-
-
?
N5-nicotinyl-L-ornithine + H2O
L-ornithine + nicotinate
-
-
-
-
?
N5-propionyl-L-ornithine + H2O
L-ornithine + propionate
-
-
-
-
?
N5-propionyl-L-ornithine + H2O
L-ornithine + propionate
-
-
-
-
?
N6-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
N6-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
N6-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
N6-acetyl-L-lysine + H2O
L-lysine + acetate
-
-
-
-
?
N6-acetyl-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
N6-acetyl-ornithine + H2O
L-ornithine + acetate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-benzoyl-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-carbobenzoxy-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-carbobenzoxy-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-carbobenzoxy-L-lysine + H2O
L-lysine + benzoate
-
-
-
-
?
N6-chloroacetyl-L-lysine + H2O
L-lysine + chloroacetate
-
-
-
-
?
N6-chloroacetyl-L-lysine + H2O
L-lysine + chloroacetate
-
-
-
-
?
N6-chloroacetyl-L-lysine + H2O
L-lysine + chloroacetate
-
-
-
-
?
N6-chloroacetyl-L-lysine + H2O
L-lysine + chloroacetate
-
-
-
-
?
N6-chloroacetyl-L-lysine + H2O
L-lysine + chloroacetate
-
very slight activity
-
-
?
N6-chloroacetyl-ornithine + H2O
L-ornithine + chloroacetate
-
-
-
-
?
N6-chloroacetyl-ornithine + H2O
L-ornithine + chloroacetate
-
-
-
-
?
N6-formyl-L-lysine + H2O
L-lysine + formate
-
-
-
-
?
N6-formyl-L-lysine + H2O
L-lysine + formate
-
-
-
-
?
N6-nicotinyl-L-Lysine + H2O
L-lysine + nicotinate
-
-
-
-
?
N6-nicotinyl-L-Lysine + H2O
L-lysine + nicotinate
-
-
-
-
?
N6-propionyl-lysine + H2O
L-lysine + propionate
-
-
-
-
?
N6-propionyl-lysine + H2O
L-lysine + propionate
-
-
-
-
?
N6-propionyl-ornithine + H2O
L-ornithine + propionate
-
-
-
-
?
N6-propionyl-ornithine + H2O
L-ornithine + propionate
-
-
-
-
?
additional information
?
-
-
enzyme is inducibly formed by N6-benzoyl-L-, -D-, or -DL-lysine, no optical specificity on hydrolysis of N6-acyl-DL-lysine, the differences indicate that the epsilon-lysine acylases from animal, mould and bacterial sources are different enzymes
-
-
?
additional information
?
-
Sm-ELA catalyzes not only the hydrolysis of various Nepsilon-acyl-L-lysines but also the synthesis of Nepsilon-acyl-L-lysines from L-lysine hydrochloride and medium-/long-chain fatty acids, including Nepsilon-lauroyl-L-lysine
-
-
?
additional information
?
-
-
Sm-ELA catalyzes not only the hydrolysis of various Nepsilon-acyl-L-lysines but also the synthesis of Nepsilon-acyl-L-lysines from L-lysine hydrochloride and medium-/long-chain fatty acids, including Nepsilon-lauroyl-L-lysine
-
-
?
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Chibata, I.; Ishikawa, T.; Tosa, T.
epsilon-lysine acylase from Achromobacter pestifer
Methods Enzymol.
19
756-762
1970
Achromobacter pestifer, Aspergillus oryzae, Gallus gallus, Columba sp., Mushroom, Pseudomonas sp., Rattus norvegicus, Sus scrofa
-
brenda
Leclerc, J.; Benoiton, L.
Further studies on epsilon-lysine acylase. The omega-N-acyl-diamino acid hydrolase activity of avian kidney
Can. J. Biochem.
46
471-474
1968
Gallus gallus, Columba sp., Rattus norvegicus, Sus scrofa
brenda
Koreishi, M.; Kawasaki, R.; Imanaka, H.; Imamura, K.; Takakura, Y.; Nakanishi, K.
Efficient Nepsilon-lauroyl-L-lysine production by recombinant epsilon-lysine acylase from Streptomyces mobaraensis
J. Biotechnol.
141
160-165
2009
Streptomyces mobaraensis (C4B800), Streptomyces mobaraensis
brenda