Information on EC 3.5.1.123 - gamma-glutamylanilide hydrolase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.5.1.123
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RECOMMENDED NAME
GeneOntology No.
gamma-glutamylanilide hydrolase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aniline degradation
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SYSTEMATIC NAME
IUBMB Comments
N5-phenyl-L-glutamine amidohydrolase
The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that cayalysed by EC 6.3.1.18, gamma-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic.