Information on EC 3.5.1.123 - gamma-glutamylanilide hydrolase

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The expected taxonomic range for this enzyme is: Acinetobacter

EC NUMBER
COMMENTARY hide
3.5.1.123
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RECOMMENDED NAME
GeneOntology No.
gamma-glutamylanilide hydrolase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aniline degradation
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SYSTEMATIC NAME
IUBMB Comments
N5-phenyl-L-glutamine amidohydrolase
The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the opposite reaction from that cayalysed by EC 6.3.1.18, gamma-glutamylanilide synthase, which is part of an aniline degradation pathway. Its purpose is likely to maintain a low concentration of N5-phenyl-L-glutamine, which is potentially toxic.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N5-phenyl-L-glutamine + H2O
L-glutamate + aniline
show the reaction diagram
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additional information
?
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a recombinant Pseudomonas strain harboring only atdA2 hydrolyzes gamma-glutamate into aniline, reversing the gamma-glutamate formation by AtdA1, a glutamine synthetase (GS)-like protein, EC 6.3.1.18
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N5-phenyl-L-glutamine + H2O
L-glutamate + aniline
show the reaction diagram
-
-
-
-
?
additional information
?
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a recombinant Pseudomonas strain harboring only atdA2 hydrolyzes gamma-glutamate into aniline, reversing the gamma-glutamate formation by AtdA1, a glutamine synthetase (GS)-like protein, EC 6.3.1.18
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene atdA2, recombinant expression in enzyme-deficient, non-catechol-degrading Pseudomonas putida strain KT2440
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