Information on EC 3.4.24.19 - procollagen C-endopeptidase

Word Map on EC 3.4.24.19
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)

The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.24.19
-
RECOMMENDED NAME
GeneOntology No.
procollagen C-endopeptidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
cleavage of the C-terminal propeptide at Ala-/-Asp in type I and II procollagens and at Arg-/-Asp in type III
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
68651-95-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme belongs to the astacin family
malfunction
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-(4'-(dimethylaminophenylazo)-benzoyl)-Arg-Tyr-Tyr-Arg-Ala-Asp-Asp-Ala-Asn-Val-Glu-(EDANS)-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
bovine lysyl oxidase-like precursor protein + H2O
?
show the reaction diagram
-
cleaved at a Gly-Asp and Ser-Asp bond
-
-
?
chordin + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen type I + H2O
?
show the reaction diagram
-
affinity of C-terminal CUB/EGF PCP constructs for collagen type I is weaker than that for procollagen type I
-
-
?
FAPYYGDEPMDF + H2O
FAPYYG + DEPMDF
show the reaction diagram
-
low enzyme activity
-
-
?
FYRADQPR + H2O
FYRA + DQPR
show the reaction diagram
-
-
-
-
?
lamin 5 + H2O
?
show the reaction diagram
-
gamma2 chain cleaved at a Gly-Asp bond, also cleavage of alpha3 chain
-
-
?
Mca-YVADAPK(Dnp)-OH + H2O
?
show the reaction diagram
-
-
-
-
?
mini-procollagen III + H2O
?
show the reaction diagram
-
-
-
-
?
pC-collagen + H2O
?
show the reaction diagram
-
-
-
-
?
pro-apoAI + H2O
mature apoAI + ?
show the reaction diagram
-
-
-
-
?
pro-collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
pro-collagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
pro-collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
pro-lysyl oxidase + H2O
?
show the reaction diagram
-
cleaved at site Met-Val-Gyl-Asp-Asp-Pro
-
-
?
probiglycan + H2O
?
show the reaction diagram
-
-
-
-
?
Procollagen + H2O
?
show the reaction diagram
-
-
-
-
?
procollagen 1 + H2O
?
show the reaction diagram
-
-
-
-
?
procollagen C-propeptide + H2O
?
show the reaction diagram
procollagen I + H2O
pCcollagen + oligopeptide
show the reaction diagram
Procollagen type I + H2O
?
show the reaction diagram
Procollagen type I + H2O
Type I pNcollagen + C-propeptides
show the reaction diagram
procollagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
Procollagen type II + H2O
Type II pNcollagen + C-propeptides
show the reaction diagram
procollagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
Procollagen type III + H2O
Type III pNcollagen + C-propeptides
show the reaction diagram
procollagen type VII + H2O
?
show the reaction diagram
-
cleaved at an Ala-Asp bond
-
-
?
PYYGDE + H2O
PYYG + DE
show the reaction diagram
-
-
-
-
?
PYYGDEP + H2O
PYYG + DEP
show the reaction diagram
-
-
-
-
?
PYYGDEPM + H2O
PYYG + DEPM
show the reaction diagram
-
high enzyme activity
-
-
?
thrombospondin-1 + H2O
?
show the reaction diagram
-
thrombospondin-1 is differently cleaved by both BMP1 and its catalytic domain
-
-
?
truncated procollagen VII + H2O
?
show the reaction diagram
-
the protease domain alone cleaves truncated procollagen VII within the short telopeptide region into fragments of similar size as the full-length enzyme does. The C-terminal domains of BMP1 are important for substrate recognition and for controlling and restricting its proteolytic activity via exosite binding
-
-
?
Type I/III/III pCcollagen + H2O
Type I/II/III collagen + C-propeptides
show the reaction diagram
YYGDEPM + H2O
YYG + DEPM
show the reaction diagram
-
-
-
-
?
YYRADDAN + H2O
YYRA + DDAN
show the reaction diagram
-
low enzyme activity
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
pro-apoAI + H2O
mature apoAI + ?
show the reaction diagram
-
-
-
-
?
pro-collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
pro-collagen type II + H2O
?
show the reaction diagram
-
-
-
-
?
pro-collagen type III + H2O
?
show the reaction diagram
-
-
-
-
?
Procollagen + H2O
?
show the reaction diagram
-
-
-
-
?
procollagen C-propeptide + H2O
?
show the reaction diagram
procollagen I + H2O
pCcollagen + oligopeptide
show the reaction diagram
Procollagen type I + H2O
?
show the reaction diagram
-
enzyme is involved in the processing of type I procollagen
-
-
-
additional information
?
-
-
the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro
-
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3R)-3-(3-[[acetyl(methyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-(6-aminopyridin-3-yl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-([[(aminooxy)sulfinyl]amino]methyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(acetylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(carbamoylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(cyclobutylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-3-[3-[(tert-butylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-(3-[[(cyclopropylsulfonyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-(2-furyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[(cyclopropylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[(ethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-3-[3-[6-(dimethylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-phenyl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrazin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-5-yl-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[2-[(methylsulfinyl)amino]ethyl]-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(1-methylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(2-hydroxy-1,1-dimethylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1-methyl-1H-imidazol-2-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4H-pyrazol-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(6-methylpyridazin-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(morpholin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-2-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-3-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(4-hydroxypiperidin-1-yl)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(methylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
-
-
(NH4)2SO4
-
-
1,10-phenanthroline
1,4-dithio-L-threitol
-
-
1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide
-
-
1H-pyrazol-4-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
2,2'-dipyridyl
-
-
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N,N-dimethylpyridine-4-carboxamide
-
-
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N-methylpyridine-4-carboxamide
-
-
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxamide
-
-
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxylic acid
-
-
2-(N-((3s,5s,7s)-adamantan-1-yl)-4-methoxyphenylsulfonamido)-N-hydroxyacetamide
-
9-21% inhibition at 0.010 mM
2-mercaptoethanol
-
-
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-5-methyl-1,3-oxazole-4-carboxamide
-
-
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-5-methyl-1,3-oxazole-4-carboxamide
-
-
2-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]benzoic acid
-
32% inhibition at 0.010 mM
3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
-
-
4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
-
-
4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide
-
-
4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid
-
-
4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide
-
-
5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-2-carboxylic acid
-
-
5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-3-carboxylic acid
-
-
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-(phenylsulfonyl)-1,2,4-oxadiazole-3-carboxamide
-
-
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(3,4-dimethoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
-
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-fluorophenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
-
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
-
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methylphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
-
-
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
-
i.e. UK-383,367. Good selectivity over matrix metalloproteinases involved in wound healing, effective in a cell-based model of collagen deposition and in penetrating human skin in vitro
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
-
good selectivity over matrix metalloproteinases involved in wound healing
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N-isopropyl-1,2,4-oxadiazole-3-carboxamide
-
-
6-aminohexanoic acid
-
-
Ac-Met-Val-Gly-Asp-Asp-Pro-Tyr-Asn-NH2
-
weak inhibitor
acidic dipeptide hydroxamate derivates
-
mimic the location of aspartic acid residues in the P1' and P2' positions of the PCP cleavage site in procollagen
-
alpha2-Macroglobulin
-
-
-
Amines
-
-
Arg
-
inhibits at 5-10 mM
Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn-Cys-Ser-Gln-Pro-Val-His-Leu-Pro-Asp-Gln
peptide derived from amino acids 727-745 of chordin
Blood serum
-
-
-
Bovine alpha2-macroglobulin
-
-
-
butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate
-
-
-
CdCl2
-
-
Chicken alpha2-macroglobulin
-
-
-
chymostatin
-
-
CoCl2
-
-
concanavalin A
-
CuCl2
cyclopropyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
Cys-Asp-Pro-Ile-Val-Cys
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
di-/tripeptidic hydroxamic acid derivates
-
-
-
diisopropylphosphofluoridate
ethyl 3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
-
-
ethyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
-
-
ethyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
Fetal bovine serum
-
weak
-
Fetal calf serum
-
-
-
Gln-Lys-Arg-Thr-Val-Ile-Cys-Asp-Pro-Ile-Val-Cys-Pro-Pro-Leu-Asn
glycine
-
weak
L-alanine
-
weak
L-arginine
L-lysine
leupeptin
Lys
-
inhibits at 5-10 mM
Metal chelators
-
methyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)piperidine-1-sulfinate
-
-
methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]methylamidosulfite
-
-
methyl [4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)phenyl]amidosulfite
-
-
methyl [5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridin-2-yl]amidosulfite
-
-
MnCl2
-
-
N-ethylmaleimide
-
inhibits at 20 mM
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide
-
-
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide
-
-
N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
-
-
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide
-
-
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide
-
-
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide
-
-
N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(2-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
45% inhibition at 0.010 mM
N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide
-
-
N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N-[(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)carbonyl]glycine
-
-
N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine
-
-
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide
-
-
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide
-
-
N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide
-
-
N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide
-
-
N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
-
-
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
-
N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide
-
-
N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine
-
-
N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine
-
-
N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide
-
-
N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
-
N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
-
N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide
-
-
Na2SO4
-
-
Na3PO4
-
-
NaCl
-
inhibits at 200-500 mM
NH4Cl
-
weak
NiCl2
-
-
Ovostatin
-
weak
-
Pepstatin
phenyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
phosphoramidon
-
weak
PMSF
-
weak
pyridin-2-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
pyridin-3-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
-
-
reduced glutathione
-
-
small molecule ox(adi)azolyl-hydroxamic acid derivates
-
-
-
sulfonamide hydrxamate derivates of ornithine analogs
-
-
-
Synthetic peptides
-
with amino acid sequences similar to the amino acid sequence around the sites at which the C-propeptides are cleaved during the conversion of procollagen to collagen in vivo, e.g. Tyr-Tyr-Arg-Ala-Asp-Asp-Ala, 35-60% inhibition at 6-12 mM, shorter peptides containing the Ala-Asp bond cleaved by the enzyme are less effective
-
Tris-HCl buffer
-
inhibits at 200-500 mM
Tyr-Tyr-Arg-Ala-Asp-Asp-Ala
-
weak inhibitor
ZnCl2
[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Enhancer glycoprotein
-
Frizzled-related protein
-
secreted Frizzled-related protein sFRP2 serves as a direct enhancer of procollagen C proteinase activity of tolloid-like metalloproteinases. The level of fibrosis, in which procollagen processing by tolloid-like proteinases has a rate-limiting role, is markedly reduced in Sfrp2-null mice subjected to myocardial infarction. This reduced level of fibrosis is accompanied by significantly improved cardiac function
-
heparin
-
stimulation of BMP-1 activity by procollagen C-proteinase enhancer-1 is further increased by the presence of 0.05 mg/ml heparin
Heparin sulfate
-
in the presence of both procollagen C-proteinase enhancer-1 and heparin or heparan sulfate, the activity of BMP-1 is further stimulated
PCPE-1
-
enhances degredation of procollagen type I 5 fold, enhances C-terminal processing of procollagen type III when this substrate is in its native, disulfide-bonded conformation, has no effect on the in vitro BMP-1 processing of procollagen VII, procollagen V N-propeptide, laminin 5 gamma2 chain, osteoglycin, prolysyl oxidase or chordin
-
procollagen C-proteinase enhancer 1
-
procollagen C-proteinase enhancer 2
-
specifically activates bone morphogenetic protein-1, the CUB domains CUB1 and CUB2 of procollagen C-proteinase enhancer 1 are capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity
-
procollagen C-proteinase enhancer-1
-
procollagen C-proteinase enhancer-2
-
procollagen C-proteinase enhancer-2 (PCPE2) interacts with BMP-1 and pro-apoAI to form a ternary pro-apoAI/BMP-1/PCPE2 complex, PCPE2 enhances the BMP-1 cleavage and maturation of pro-apoAI
-
TGFbeta
-
increases the expression of BMP-1 and Tld in human dermal fibroblasts
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000096
Procollagen type I
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0056 - 0.0083
Procollagen type I
Homo sapiens
-
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000003
(3R)-3-(3-[[acetyl(methyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000018
(3R)-3-[3-(6-aminopyridin-3-yl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000122
(3R)-3-[3-(aminomethyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000098
(3R)-3-[3-([[(aminooxy)sulfinyl]amino]methyl)-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000019
(3R)-3-[3-[(acetylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000324
(3R)-3-[3-[(carbamoylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000006
(3R)-3-[3-[(cyclobutylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.00001
(3R)-3-[3-[(tert-butylamino)methyl]-1,2,4-oxadiazol-5-yl]-6-cyclohexyl-N-hydroxyhexanamide
Homo sapiens
-
-
0.000015
(3R)-6-cyclohexyl-3-(3-[[(cyclopropylsulfonyl)amino]methyl]-1,2,4-oxadiazol-5-yl)-N-hydroxyhexanamide
Homo sapiens
-
-
0.00001
(3R)-6-cyclohexyl-3-[3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000046
(3R)-6-cyclohexyl-3-[3-(2-furyl)-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000006
(3R)-6-cyclohexyl-3-[3-[(cyclopropylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000031
(3R)-6-cyclohexyl-3-[3-[(dimethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000021
(3R)-6-cyclohexyl-3-[3-[(ethylamino)methyl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000028
(3R)-6-cyclohexyl-3-[3-[6-(dimethylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]-N-hydroxyhexanamide
Homo sapiens
-
-
0.000116
(3R)-6-cyclohexyl-N-hydroxy-3-(3-phenyl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000014
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrazin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000025
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000023
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-3-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000002
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000023
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-2-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000014
(3R)-6-cyclohexyl-N-hydroxy-3-(3-pyrimidin-5-yl-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.00002
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[2-[(methylsulfinyl)amino]ethyl]-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000029
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(1-methylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000008
(3R)-6-cyclohexyl-N-hydroxy-3-(3-[[(2-hydroxy-1,1-dimethylethyl)amino]methyl]-1,2,4-oxadiazol-5-yl)hexanamide
Homo sapiens
-
-
0.000092
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1-methyl-1H-imidazol-2-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000039
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(1H-pyrazol-4-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000074
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(4H-pyrazol-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.00003
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(6-methylpyridazin-3-yl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000005
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(morpholin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000006
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-2-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000006
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-3-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000028
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyridin-4-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000024
(3R)-6-cyclohexyl-N-hydroxy-3-[3-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000013
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(4-hydroxypiperidin-1-yl)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000023
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[(methylamino)methyl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000008
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.000013
(3R)-6-cyclohexyl-N-hydroxy-3-[3-[6-(methylamino)pyridin-3-yl]-1,2,4-oxadiazol-5-yl]hexanamide
Homo sapiens
-
-
0.042
1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000088
1H-pyrazol-4-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000017
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N,N-dimethylpyridine-4-carboxamide
Homo sapiens
-
-
0.00003
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)-N-methylpyridine-4-carboxamide
Homo sapiens
-
-
0.000017
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxamide
Homo sapiens
-
-
0.000006
2-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-4-carboxylic acid
Homo sapiens
-
-
0.000017
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-5-methyl-1,3-oxazole-4-carboxamide
Homo sapiens
-
-
0.000017
2-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-5-methyl-1,3-oxazole-4-carboxamide
Homo sapiens
-
-
0.000006
3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
Homo sapiens
-
-
0.000032
4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoic acid
Homo sapiens
-
-
0.01
4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid
Homo sapiens
-
pH and temperature not specified in the publication
0.00041
4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000059
5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-2-carboxylic acid
Homo sapiens
-
-
0.000017
5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridine-3-carboxylic acid
Homo sapiens
-
-
0.000007
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-(phenylsulfonyl)-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.0000018
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(3,4-dimethoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000033
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-fluorophenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000017
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methoxyphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000014
5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-N-[(4-methylphenyl)sulfonyl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000044
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.00001
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N,N-dimethyl-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.000021
5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-N-isopropyl-1,2,4-oxadiazole-3-carboxamide
Homo sapiens
-
-
0.167
butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate
Homo sapiens
-
pH and temperature not specified in the publication
-
0.000021
cyclopropyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000184
ethyl 3-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
Homo sapiens
-
-
0.000154
ethyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)benzoate
Homo sapiens
-
-
0.000026
ethyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000003
methyl 4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)piperidine-1-sulfinate
Homo sapiens
-
-
0.000011
methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000038
methyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]methylamidosulfite
Homo sapiens
-
-
0.000003
methyl [4-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)phenyl]amidosulfite
Homo sapiens
-
-
0.000027
methyl [5-(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)pyridin-2-yl]amidosulfite
Homo sapiens
-
-
0.0049
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.028
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.029
N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.073
N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.01
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
Homo sapiens
-
pH and temperature not specified in the publication
0.018
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.069
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.067
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.018
N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0022
N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.166
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.003
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.011
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.023
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.081
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0081
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00035
N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0023
N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000093
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0091
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00029
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000042
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0071
N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0004
N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00008
N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000021
N-[(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)carbonyl]glycine
Homo sapiens
-
-
1.5
N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0094
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.014
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.1
N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide
Homo sapiens
-
above, pH and temperature not specified in the publication
0.019
N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.034
N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.055
N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.102
N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0028
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
Homo sapiens
-
pH and temperature not specified in the publication
0.016
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.112
N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0047
N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide
Homo sapiens
-
pH and temperature not specified in the publication
0.04
N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine
Homo sapiens
-
pH and temperature not specified in the publication
0.085
N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine
Homo sapiens
-
pH and temperature not specified in the publication
0.0067
N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.001
N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000073
N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00038
N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00078
N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0045
N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0017
N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.017
N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.042
N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.013
N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000026
phenyl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000107
pyridin-2-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.000026
pyridin-3-yl [(5-[(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazol-3-yl)methyl]amidosulfite
Homo sapiens
-
-
0.345
[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid
Homo sapiens
-
pH and temperature not specified in the publication
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 8.5
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 8.5
-
7.5: about 80% of activity maximum, 8-8.5: activity maximum
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
gastric epithelial adenocarcinoma stimulated with Helicobacter pylori
Manually annotated by BRENDA team
-
tumor endothelial cells of malignant colorectal tissues
Manually annotated by BRENDA team
-
mTld
Manually annotated by BRENDA team
-
mTld and BMP-1
Manually annotated by BRENDA team
-
mTld and BMP-1
Manually annotated by BRENDA team
-
mTld and BMP-1
Manually annotated by BRENDA team
-
BMP1 is expressed in the ovary throughout early fetal stages to adulthood. Within ovine ovaries, immunohistochemical localization shows that BMP1 is present in granulosa cells at all stages of follicular development, from primordial to large antral follicles, and that the levels of BMP1 are not affected by the final follicle selection mechanism
Manually annotated by BRENDA team
-
mTld and BMP-1
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10700
-
immunoblotting, XBMP1-B in adults
20800
-
SDS-PAGE, purified CUB3-EGF2 PCP construct
43000
-
gel filtration
63000
-
XBMP1-A in unfertilized eggs
80670
-
XBMP1-B
82900
-
prepro-BMP1
97000 - 110000
-
gel filtration, PAGE
100000
-
SDS-PAGE, mature N-gycosylated enzyme
102000
-
1 * 102000, chicken, SDS-PAGE
110200
-
XBMP1-A
111600
-
mTld
125000
-
mouse, gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.3
-
1 h, in presence of 5 mM CaCl2, more than 80% loss of activity
31033
4.8
-
1 h, in presence of 5 mM CaCl2, more than 80% loss of activity
31033
6 - 9
-
1 h, in presence of 5 mM CaCl2, less than 20% loss of activity
31033
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
Ca2+ stabilizes against thermal inactivation
-
Lyophilization overnight, 50% loss of activity
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C
-
4°C, -20°C or -70°C in 0.3 M Tris-HCl, 1.5 M NaCl, 5 mM CaCl2, 0.02% Brij 35, 0.01% NaN3, pH 7.5, less than 25% loss of activity after 2 months
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
by anti-Flag affinity column
-
by Ni-NTA affinity chromatography
-
partial
-
to homogeneity by affinity chromatography
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in baculovirus-infected Sf21 insect cells, HT-180 cells, 293-EBNA cells or COS-7 cells
-
expression in 293-EBNA cells
-
expression in Escherichia coli BL21 (DE3)
-
recombinant bone morphogenetic protein-1 produced by a baculovirus system
-
recombinant wild-type and mutant BMP-1 expressed in COS-7 cells
-
recombinantly expressed
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C63G
-
site-directed mutagenesis
C65A
-
site-directed mutagenesis
C66G
-
site-directed mutagenesis
C85A
-
site-directed mutagenesis
E483K
-
site-directed mutagenesis
E94A
-
site-directed mutagenesis
K176A
-
site-directed mutagenesis
K87A
-
site-directed mutagenesis
K87A/K176A
-
site-directed mutagenesis
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
additional information
-
involved in deposition of collagen fibrils in the extracellular matrix following processing of procollagen propeptides, dorsoventral patterning through cleavage of chordin, collagen and elastin cross-linking by processing of inactive precursors of lysyl oxidases, proteoglycan maturation and assembly of the dermal-epidermal junction by processing of laminin 5 chains and cleaving the C-propeptide of type VII procollagen