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Synonyms
fap, fapalpha, fap-alpha, fibroblast activation protein-alpha, antiplasmin-cleaving enzyme, fibroblast activation factor, z-pro-prolinal-insensitive peptidase,
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Boc-Ala-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O
Boc-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
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Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
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L-Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O
L-Ala-Pro + 7-amino-4-trifluoromethylcoumarin
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acetyl-Gly-Pro-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate + H2O
acetyl-Gly-Pro + 9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate
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acetyl-Gly-Pro-Gly-Pro-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate + H2O
acetyl-Gly-Pro-Gly-Pro + 9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate
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most efficient substrate, FAP shows a greater catalytic efficiency for acetyl-Gly-Pro-Gly-Pro-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate than for acetyl-Gly-Pro-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate and TSGP-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate
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Ala-Pro-Ala-Pro-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate + H2O
Ala-Pro-Ala-Pro + 9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate
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complement C1q tumor necrosis factor-related protein 6 + H2O
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cleavage at position 26 after a Val-Pro sequence
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CXCL-5 + H2O
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processing of CXCL-5 at position 42, which is after an Ala-Pro sequence
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extracellular matrix protein 1 + H2O
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cleavage occurrs at position 142 after a Lys-Pro sequence
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extracellular matrix protein CN-I + H2O
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extracellular matrix protein CN-III + H2O
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extracellular matrix protein CN-V + H2O
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fibrillin-2 + H2O
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cleavage occurrs at position 60, in the propeptide domain, after a Gly-Pro sequence
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lysyl oxidase homolog 2 + H2O
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cleavage at position 36 after a Tyr-Pro sequence that follows the signal peptide
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TSGP-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate + H2O
TSGP + 9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate
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Type I collagen + H2O
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type III collagen + H2O
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type V collagen + H2O
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additional information
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Collagen + H2O
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Collagen + H2O
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cleavage of type I collagen by fibroblast activation protein-? enhances class A scavenger receptor mediated macrophage adhesion
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additional information
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shows no activity with Gly-Pro-Gly-Pro-9-di-3-sulfonylpropylaminobenzo[a]phenoxazonium perchlorate
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additional information
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the enzyme has both dipeptidyl aminopeptidase and endopeptidase activities, and can hydrolyze the post-proline bond
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Collagen + H2O
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cleavage of type I collagen by fibroblast activation protein-? enhances class A scavenger receptor mediated macrophage adhesion
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complement C1q tumor necrosis factor-related protein 6 + H2O
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cleavage at position 26 after a Val-Pro sequence
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?
CXCL-5 + H2O
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processing of CXCL-5 at position 42, which is after an Ala-Pro sequence
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?
extracellular matrix protein 1 + H2O
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cleavage occurrs at position 142 after a Lys-Pro sequence
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?
extracellular matrix protein CN-I + H2O
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extracellular matrix protein CN-III + H2O
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extracellular matrix protein CN-V + H2O
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fibrillin-2 + H2O
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cleavage occurrs at position 60, in the propeptide domain, after a Gly-Pro sequence
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?
lysyl oxidase homolog 2 + H2O
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cleavage at position 36 after a Tyr-Pro sequence that follows the signal peptide
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?
Type I collagen + H2O
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type III collagen + H2O
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type V collagen + H2O
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additional information
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the enzyme has both dipeptidyl aminopeptidase and endopeptidase activities, and can hydrolyze the post-proline bond
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?
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lowenzyme activity
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lowenzyme activity
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver
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high enzyme activity
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lowenzyme activity
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high enzyme activity
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high enzyme activity
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lowenzyme activity
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high enzyme activity
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additional information
the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver. Highest levels of enzyme activity occur in uterus, pancreas, submaxillary gland and skin, whereas the lowest levels ar found in brain, prostate, leukocytes and testis
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additional information
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the protease fibroblast activation protein is a specific marker of activated mesenchymal cells in tumor stroma and fibrotic liver. Highest levels of enzyme activity occur in uterus, pancreas, submaxillary gland and skin, whereas the lowest levels ar found in brain, prostate, leukocytes and testis
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additional information
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not expressed in melanomas
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additional information
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expression is very low in adult organs, but is upregulated by activated fibroblasts in sites of tissue remodeling, including fibrosis, atherosclerosis, arthritis and tumors
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Ramirez-Montagut, T.; Blachere, N.E.; Sviderskaya, E.V.; Bennett, D.C.; Rettig, W.J.; Garin-Chesa, P.; Houghton, A.N.
FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor
Oncogene
23
5435-5446
2004
Mus musculus, Mus musculus C57BL/6
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O'Brien, P.; O'Connor, B.F.
Seprase: An overview of an important matrix serine protease
Biochim. Biophys. Acta
1784
1130-1145
2008
Bos taurus, Gallus gallus, Mus musculus (P97321), Homo sapiens (Q12884), Xenopus laevis (Q91651)
brenda
Lai, K.S.; Ho, N.; Cheng, J.D.; Tung, C.
Selective fluorescence probes for dipeptidyl peptidase activity-fibroblast activation protein and dipeptidyl peptidase IV
Bioconjug. Chem.
18
1246-1250
2007
Mus musculus
brenda
Keane, F.M.; Yao, T.W.; Seelk, S.; Gall, M.G.; Chowdhury, S.; Poplawski, S.E.; Lai, J.H.; Li, Y.; Wu, W.; Farrell, P.; Vieira de Ribeiro, A.J.; Osborne, B.; Yu, D.M.; Seth, D.; Rahman, K.; Haber, P.; Topaloglu, A.K.; Wang, C.; Thomson, S.; Hennessy, A.; Prins, J.; Twigg, S.M.; McLennan, S.V.; McCaughan, G.W.; Ba, B.a.c.
Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs
FEBS open bio
4
43-54
2013
Papio sp., Mus musculus (P97321), Mus musculus, Homo sapiens (Q12844), Homo sapiens
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Zhang, H.E.; Hamson, E.J.; Koczorowska, M.M.; Tholen, S.; Chowdhury, S.; Bailey, C.G.; Lay, A.J.; Twigg, S.M.; Lee, Q.; Roediger, B.; Biniossek, M.L.; ORourke, M.B.; McCaughan, G.W.; Keane, F.M.; Schilling, O.; Gorrell, M.D.
Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics
Mol. Cell. Proteomics
18
65-85
2019
Mus musculus
brenda
Mazur, A.; Holthoff, E.; Vadali, S.; Kelly, T.; Post, S.R.
Cleavage of type I collagen by fibroblast activation protein-alpha enhances class A scavenger receptor mediated macrophage adhesion
PLoS ONE
11
e0150287
2016
Mus musculus
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