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benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-L-Arg + p-nitroaniline
-
-
-
-
?
D-Phe-Pip-Arg-4-nitroanilide + H2O
D-Phe-Pip-Arg + 4-nitroaniline
-
i.e. S-2238
-
-
?
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O
D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline
-
i.e. S2238, synthetic chromogenic substrate
-
?
factor V + H2O
activated factor V + ?
-
activation
-
-
?
factor VIII + H2O
activated factor VIII + ?
-
activation
-
-
?
factor X + H2O
factor Xa + propeptide
-
-
-
-
?
factor XI + H2O
activated factor XI + ?
-
activation
-
-
?
factor XII + H2O
activated factor XII + ?
factor XIII + H2O
factor XIIIa + propeptide
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
fibrinogen + H2O
fibrin + fibrinopeptide A + fibrinopeptide B
-
-
-
-
?
GLVPRGVNL + H2O
GLVPR + GVNL
-
residues 33-41 of factor XIII with mutation V34L
-
-
?
GVVPRGVNL + H2O
GVVPR + GVNL
-
residues 33-41 of factor XIII
-
-
?
N-(4-tosyl)-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
N-(4-tosyl)-Gly-L-Pro-L-Arg + 4-nitroaniline
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Arg 4-nitrophenyl ester + H2O
Nalpha-benzyloxycarbonyl-L-Arg + 4-nitrophenol
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Lys 4-nitrophenyl ester + H2O
Nalpha-benzyloxycarbonyl-L-Lys + 4-nitrophenol
-
-
-
-
?
protease-activated receptor + H2O
?
-
activation
-
-
?
protease-activated receptor + H2O
activated protease-activated receptor + ?
-
activation
-
-
?
protease-activated receptor-1 + H2O
?
-
activation
-
-
?
protease-activated receptor-3 + H2O
?
-
activation
-
-
?
protease-activated receptor-4 + H2O
?
-
activation
-
-
?
protein C zymogen + H2O
activated protein C + propeptide
S-thanatin + H2O
?
-
-
-
-
?
Tosyl-Arg methyl ester + H2O
Tosyl-Arg + methanol
-
-
-
-
?
TVELQGLVPRGVNL + H2O
TVELQGLVPR + GVNL
-
residues 28-41 of factor XIII with mutation V34L
-
-
?
TVELQGVVPRGVNL + H2O
TVELQGVVPR + GVNL
-
residues 28-41 of factor XIII
-
-
?
additional information
?
-
factor XII + H2O
activated factor XII + ?
-
-
-
-
?
factor XII + H2O
activated factor XII + ?
-
activated factor XII cross-links fibrin molecules and stabilizes the fibrin clot
-
-
?
Fibrinogen + H2O
?
-
cleavage of four Arg-Gly peptide bonds
-
-
?
Fibrinogen + H2O
?
-
cleavage of four Arg-Gly peptide bonds, the enzyme is involved in the final step in the coagulation of mammalian blood
-
-
?
fibrinogen + H2O
fibrin + ?
-
-
-
-
?
fibrinogen + H2O
fibrin + ?
-
the enzyme mediates the conversion of fibrinogen to fibrin
-
-
?
protein C zymogen + H2O
activated protein C + propeptide
-
activation
-
-
?
protein C zymogen + H2O
activated protein C + propeptide
-
activated protein C has a regulatory function in inhibiting thrombin activation, overview
-
-
?
additional information
?
-
determination of enzyme activity by active site titration with 4-nitrophenyl guanidino-benzoate
-
?
additional information
?
-
-
cleavage sites in macromolecular substrates
-
-
?
additional information
?
-
-
enzyme stimulates a marked increase in inositol phosphate accumulation, which is fully mimicked by a selective PAR1 activating peptide. Mitogenic effect of enzyme involves activation of PDGF or EGF receptors and a Gi/o-dependent activation of phosphoinositide 3-kinase. Enzyme stimulates phosphatidylinositol-3,4,5-triphosphate mass accumulation
-
-
?
additional information
?
-
-
thrombin is a multifunctional trypsin-like protease that plays a role in the blood coagulation system, stimulates platelet aggregation, and promotes its own generation through the activation of factor XI and cofactors V and VII
-
-
?
additional information
?
-
-
when binding to thrombomodulin, thrombin can activate the protein C to regulate coagulation by inhibiting thrombin generation
-
-
?
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napsagatran
binding mode to the enzyme, crystal structure
napsagatran ethyl ester
binding mode to the enzyme, crystal structure
activated protein C
-
activated protein C has a regulatory function in inhibiting thrombin activation, overview
-
amentoflavone
-
slight inhibition
Baicalin
-
slight inhibition
dihydromyricetin
-
slight inhibition
epicatechin
-
slight inhibition
galangin
-
slight inhibition
glycosaminoglycan AD17
-
-
-
glycosaminoglycan AD4
-
shows only small inhibitory activity toward thrombin and the inhibition does not proceed beyond 40% inhibition
-
glycosaminoglycan AD9
-
shows only small inhibitory activity toward thrombin and the inhibition does not proceed beyond 40% inhibition
-
glycosaminoglycan AE11
-
modest inhibitory effect on thrombin activity
-
glycosaminoglycan AE15
-
-
-
glycosaminoglycan AE29
-
-
-
glycosaminoglycan AE6
-
modest inhibitory effect on thrombin activity
-
glycosaminoglycan CS-D
-
-
-
glycosaminoglycan CS-E
-
-
-
glycosaminoglycan DE17
-
-
-
glycosaminoglycan DE2
-
-
-
glycosaminoglycan DE9
-
-
-
hemalin
-
protein of about 20 kDa, isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis. Hemalin delays bovine plasma clotting time and inhibits both thrombin-induced fibrinogen clotting and platelet aggregation. Hemalin may play a role in tick blood feeding
-
heparin
-
from porcine mucosa, inhibitory effect on fluid-phase and surface-bound thrombin in vivo in rabbits and in vitro
heparin cofactor II
-
inhibitory effect on fluid-phase and surface-bound thrombin
-
hesperetin
-
slight inhibition
hesperidin
-
slight inhibition
hyperin
-
slight inhibition
Intimatan
-
heparin cofactor II agonist, inhibitory effect on fluid-phase and surface-bound thrombin in vivo in rabbits and in vitro
isohamnetin 3-O-nehesperridin
-
slight inhibition
isorhamnetin 3-O-(6-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside
-
slight inhibition
kaempferol 3-O-(2'',4''-di-(E)-p-coumaroyl)-rhamnoside
-
-
kaempferol 3-O-(2''-p-coumaroyl)-rhamnoside
-
-
kaempferol 3-O-(2-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside
-
slight inhibition
kaempferol 3-O-beta-D-glucoside
-
slight inhibition
Myricitrin
-
slight inhibition
naringenin
-
slight inhibition
naringin
-
slight inhibition
puerarin
-
slight inhibition
quercetin 3-O-rhamnose(1-2)glucose(6-1)rhamnose
-
slight inhibition
rutin
-
slight inhibition
thrombin inhibitor from Naja haje
-
thrombin inhibitor from Naja haje is a noncytotoxic phospholipase A2, mixed-type inhibitor of thrombin, inhibits the fibrinogenolytic and amidolytic activities of thrombin as well as its ability to induce platelet aggregation, it does not hydrolyze thrombin
-
Thrombomodulin
-
complex formation on endothelial cell surfaces blocks thrombin activity
-
typhaneoside
-
slight inhibition
additional information
-
a series of natural flavonoids as thrombin inhibitors, structure-activity relationships, molecular docking, overview
-
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Lundblad, R.L.; Kingdon, H.S.; Mann, K.G.
Thrombin
Methods Enzymol.
45
156-176
1976
Bos taurus, Equus caballus, Homo sapiens, Sus scrofa
brenda
Lundblad, R.L.; Uhteg, L.C.; Vogel, C.N.; Kingdon, H.S.; Mann, K.G.
Preparation and partial characterization of two forms of bovine thrombin
Biochem. Biophys. Res. Commun.
66
482-489
1975
Bos taurus
brenda
Giglio, J.R.; Rossi, A.; Leone, F.A.; Chiericato, G.; Say, J.C.
Isolation and characterization of an active three-chain molecular species of bovine thrombin
Biochem. J.
159
29-33
1976
Bos taurus
brenda
Ascenzi, P.; Menegatti, E.; Bolognesi, M.; Guarneri, M.; Amiconi, G.
Catalytic properties of bovine alpha-thrombin: a comparative steady-state and pre-steady-state study
Biochim. Biophys. Acta
871
319-323
1986
Bos taurus
brenda
Brandstetter, H.; Turk, D.; Hoeffken, H.W.; Grosse, D.; Sturzebecher, J.; Martin, P.D.; Edwards, B.F.; Bode, W.
Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics
J. Mol. Biol.
226
1085-1099
1992
Bos taurus
brenda
Dullweber, F.; Stubbs, M.T.; Musil, D.; Sturzebecher, J.; Klebe, G.
Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition
J. Mol. Biol.
313
593-614
2001
Homo sapiens, Bos taurus (P00735)
brenda
Buchanan, M.R.; Maclean, G.A.; Brister, S.J.
Selective and sustained inhibition of surface-bound thrombin activity by intimatan/heparin cofactor II and its relevance to assessing systemic anticoagulation in vivo, ex vivo and in vitro
Thromb. Haemost.
86
909-913
2001
Bos taurus, Homo sapiens
brenda
Walker, T.R.; Cadwallader, K.A.; MacKinnon, A.; Chilvers, E.R.
Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors
Biochem. Pharmacol.
70
959-967
2005
Bos taurus
brenda
Isetti, G.; Maurer, M.C.
Thrombin activity is unaltered by N-terminal truncation of factor XIII activation peptides
Biochemistry
43
4150-4159
2004
Bos taurus
brenda
Croy, C.H.; Koeppe, J.R.; Bergqvist, S.; Komives, E.A.
Allosteric changes in solvent accessibility observed in thrombin upon active site occupation
Biochemistry
43
5246-5255
2004
Bos taurus, Homo sapiens
brenda
Iyaguchi, D.; Yao, M.; Watanabe, N.; Tanaka, I.; Toyota, E.
Crystallization and preliminary x-ray studies of the unliganded wild-type bovine thrombin
Protein Pept. Lett.
14
923-924
2007
Bos taurus
brenda
Doria, C.; Fischer, C.P.; Wood, C.G.; Li, P.M.; Marra, S.; Hart, J.
Phase 3, randomized, double-blind study of plasma-derived human thrombin versus bovine thrombin in achieving hemostasis in patients undergoing surgery
Curr. Med. Res. Opin.
24
785-794
2008
Bos taurus, Homo sapiens
brenda
Liao, M.; Zhou, J.; Gong, H.; Boldbaatar, D.; Shirafuji, R.; Battur, B.; Nishikawa, Y.; Fujisaki, K.
Hemalin, a thrombin inhibitor isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis
J. Insect Physiol.
55
164-173
2009
Bos taurus
brenda
Maki, J.; Hirano, M.; Hoka, S.; Kanaide, H.; Hirano, K.
Thrombin activation of proteinase-activated receptor 1 potentiates the myofilament Ca2+ sensitivity and induces vasoconstriction in porcine pulmonary arteries
Br. J. Pharmacol.
159
919-927
2010
Bos taurus
brenda
Zhu, H.; Hoppensteadt, D.; Adiguzel, C.; Bick, R.L.; Fareed, J.
Comparison of immunogenic potentials of bovine thrombin preparations
Clin. Appl. Thromb. Hemost.
15
41-49
2009
Bos taurus
brenda
Zhu, H.; Hoppensteadt, D.; Iqbal, O.; Litinas, E.; Adiguzel, C.; Fareed, J.
Relative purity of different bovine thrombin preparations
Clin. Appl. Thromb. Hemost.
15
681-688
2009
Bos taurus
brenda
Numakura, M.; Kusakabe, N.; Ishige, K.; Ohtake-Niimi, S.; Habuchi, H.; Habuchi, O.
Preparation of chondroitin sulfate libraries containing disulfated disaccharide units and inhibition of thrombin by these chondroitin sulfates
Glycoconj. J.
27
479-489
2010
Bos taurus
brenda
Nicolaes, G.A.; Bock, P.E.; Segers, K.; Wildhagen, K.C.; Dahlback, B.; Rosing, J.
Inhibition of thrombin formation by active site Ser360 to Ala-substituted activated protein C
J. Biol. Chem.
30
22890-22900
2010
Bos taurus
brenda
Osipov, A.V.; Filkin, S.Y.; Makarova, Y.V.; Tsetlin, V.I.; Utkin, Y.N.
A new type of thrombin inhibitor, noncytotoxic phospholipase A2, from the Naja haje cobra venom
Toxicon
55
186-194
2010
Bos taurus, Homo sapiens
brenda
Wu, G.; Deng, X.; Li, X.; Wang, X.; Wang, S.; Xu, H.
Application of immobilized thrombin for production of S-thanatin expressed in Escherichia coli
Appl. Microbiol. Biotechnol.
92
85-93
2011
Bos taurus
brenda
Lin, C.H.; Cheng, H.W.; Ma, H.P.; Wu, C.H.; Hong, C.Y.; Chen, B.C.
Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway
J. Biol. Chem.
286
10483-10494
2011
Bos taurus, Homo sapiens
brenda
Kwong, K.; Nassenstein, C.; de Garavilla, L.; Meeker, S.; Undem, B.J.
Thrombin and trypsin directly activate vagal C-fibres in mouse lung via protease-activated receptor-1
J. Physiol.
588
1171-1177
2010
Bos taurus
brenda
Liu, L.; Ma, H.; Yang, N.; Tang, Y.; Guo, J.; Tao, W.; Duan, J.
A series of natural flavonoids as thrombin inhibitors: structure-activity relationships
Thromb. Res.
126
e365-e378
2010
Bos taurus
brenda
Zhang, Y.; Li, X.; Zou, R.; Xue, Y.; Lou, X.; He, M.
Bovine thrombin enhances the efficiency and specificity of polymerase chain reaction
Biotechniques
57
289-294
2014
Bos taurus
brenda
Plavsa, J.J.; Rezacova, P.; Kugler, M.; Pachl, P.; Brynda, J.; Voburka, Z.; Celic, A.; Petri, E.T.; Skerlova, J.
In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals
Acta Crystallogr. Sect. F
74
300-306
2018
Bos taurus (P00735)
brenda