Reference on EC 3.4.21.10 - acrosin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mukerji, S.K.
Studies on the rabbit proacrosin-acrosin system
Arch. Biochem. Biophys.
230
412-423
1984
Oryctolagus cuniculus
Zelezna, B.; Cechova, D.
Boar acrosin. Isolation of two active forms from boar ejaculated sperm
Hoppe-Seyler's Z. Physiol. Chem.
363
757-766
1982
Sus scrofa
Elce, J.S.; McIntyre, E.J.
Purification of bovine and human acrosin
Can. J. Biochem.
60
8-14
1981
Bos taurus, Homo sapiens
Anderson, R.A.; Beyler, S.A.; Mack, S.R.; Zaneveld, L.J.D.
Characterization of a high-molecular-weight form of human acrosin. Comparison with human pancreatic trypsin
Biochem. J.
199
307-316
1981
Homo sapiens
Mueller-Esterl, W.; Kupfer, S.; Fritz, H.
Purification and properties of boar acrosin
Hoppe-Seyler's Z. Physiol. Chem.
361
1811-1821
1980
Sus scrofa
Brown, C.R.; Hartree, E.F.
Studies on ram acrosin. Activation of proacrosin accompanying the isolation of acrosin from spermatozoa, and purification of the enzyme by affinity chromatography
Biochem. J.
175
227-238
1978
Ovis aries
Brown, C.R.; Andani, Z.; Hartree, E.F.
Studies on ram acrosin. Isolation from spermatozoa, activation by cations and organic solvents, and influence of cations on its reaction with inhibitors
Biochem. J.
149
133-146
1975
Ovis aries
Schleuning, W.D.; Fritz, H.
Some characteristics of highly purified boar sperm acrosin
Hoppe-Seyler's Z. Physiol. Chem.
355
125-130
1974
Sus scrofa
Gilboa, E.; Elkana, Y.; Rigbi, M.
Purification and properties of human acrosin
Eur. J. Biochem.
39
85-92
1973
Homo sapiens
Polakoski, K.L.; McRorie, R.A.; Williams, W.L.
Boar acrosin. I. Purification and preliminary characterization of a proteinase from boar sperm acrosomes
J. Biol. Chem.
248
8178-8182
1973
Sus scrofa
Polakoski, K.L.; McRorie, R.A.
Boar acrosin. II. Classification, inhibition, and specificity studies of a proteinase from sperm acrosomes
J. Biol. Chem.
248
8183-8188
1973
Sus scrofa
Hardy, D.M.; Schoots, A.F.M.; Hedrick, J.L.
Caprine acrosin. Purification, characterization and proteolysis of the porcine zona pellucida
Biochem. J.
257
447-453
1989
Capra hircus
Schiessler, H.; Fritz, H.; Arnold, M.; Fink, E.; Tschesche, H.
Properties of the trypsin-like (acrosin) from boar spermatozoa
Hoppe-Seyler's Z. Physiol. Chem.
353
1638-1645
1972
Sus scrofa
Ho, J.J.L.; Meizel, S.
Multiple molecular forms of avian acrosin: differences in their kinetic properties
FEBS Lett.
56
115-119
1975
Gallus gallus
Fritz, H.; Foerg-Brey, B.; Meier, M.; Arnold, M.; Tschesche, H.
Human acrosin: inhibition by protein-proteinase inhibitors
Hoppe-Seyler's Z. Physiol. Chem.
353
1950-1952
1972
Homo sapiens
Uhlenbruck, G.; Sprenger, I.; Schumacher, G.F.B.; Zaneveld, L.J.D.
Additional properties of acrosin, a proteolytic enzyme from rabbit sperm acrosomes
Naturwissenschaften
59
124-125
1972
Oryctolagus cuniculus
Planchenault, T.; Cechova, D.; Keil-Dlouha, V.
Matrix degrading properties of sperm serine proteinase, acrosin
FEBS Lett.
294
279-281
1991
Sus scrofa
Hermans, J.M.; Monard, D.; Jones, R.; Stone, S.R.
Inhibition of acrosin by serpins. A suicide substrate mechanism
Biochemistry
34
3678-3685
1995
Sus scrofa
Falase, E.A.O.; Adekunle, A.O.; Neblett, H.; Teuscher, C.
Guinea pig testicular proacrosin-acrosin system: preliminary immunological characterization
J. Reprod. Immunol.
15
241-256
1989
Cavia porcellus
Kobayashi, T.; Matsuda, Y.; Oshio, S.; Kaneko, S.; Nozawa, S; Mhori, H.; Akihama, S.; Fujimoto, Y.
Human acrosin: purification and some properties
Arch. Androl.
27
9-16
1991
Homo sapiens
Takano, H.; Yanagimachi, R.; Urch, U.A.
Evidence that acrosin activity is important for the development of fusibility of mammalian spermatozoa with the oolemma: inhibitor studies using the golden hamster
Zygote
1
79-91
1993
Mesocricetus auratus
Adekunle, A.O.; Storey, B.T.; Teuscher, C.
Guinea pig testicular proacrosin-acrosin system: further characterization of the active enzyme
Biol. Reprod.
40
127-134
1989
Cavia porcellus
Palencia, D.D.; Garner, D.L.; Hudig, D.; Holcombe, D.W.; Burner, C.A.; Redelman, D.; Fernandez, G.C.J.; Abuelyaman, A.S.; Kam, C.M.; Powers, J.C.
Determination of activable proacrosin/acrosin in bovine sperm using an irreversible isocoumarin serine protease inhibitor
Biol. Reprod.
55
536-542
1996
Bos taurus
Hoshi, K.; Sugano, T.; Yoshimatsu, N.; Yanagida, K.
Correlation of semen characteristics with acrosin, hyaluronidase, tubulin, dynein, and actin of spermatozoa
Arch. Androl.
35
165-172
1995
Homo sapiens
Suter, L.; Habenicht, U.F.
Characterization of mouse epididymal acrosin: comparative studies with acrosin from boar and human ejaculated spermatozoa
Int. J. Androl.
21
95-104
1998
Homo sapiens, Mus musculus, Sus scrofa
Zheng, X.L.; Geiger, M.; Ecke, S.; Resch, I.; Eberspaechler, U.; Donner, P.; Schleuning, W.D.; Binder, B.R.
Serine protease inhibitors (serpins) in human seminal plasma: concentrations and inhibition of acrosin
Fibrinolysis
8
364-371
1994
Sus scrofa
-
NagDas, S.K.
Bovine epididymal sperm proacrosin-acrosin system: quantification and partial characterization
Andrologia
24
171-178
1992
Bos taurus
Richardson, M.E.; Korn, N.; Bodine, A.B.; Thurston, R.J.
Research note: kinetic and inhibition studies with turkey acrosin
Poult. Sci.
71
1789-1793
1992
Meleagris gallopavo
Froman, D.P.
Chicken acrosin: extraction and purification
Poult. Sci.
69
812-817
1990
Gallus gallus
Smith, R.; Jenkins, A.; Lourbakos, A.; Thompson, P.; Ramakrishnan, V.; Tomlinson, J.; Deshpande, U.; Johnson, D.A.; Jones, R.; Mackie, E.J.; Pike, R.N.
Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes
FEBS Lett.
484
285-290
2000
Sus scrofa
Hermans, J.M.; Haines, D.S.; James, P.S.; Jones, R.
Kinetics of inhibition of sperm beta-acrosin activity by suramin
FEBS Lett.
544
119-122
2003
Ovis aries, Sus scrofa
Tranter, R.; Read, J.A.; Jones, R.; Brady, R.L.
Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin
Structure Fold. Des.
8
1179-1188
2000
Sus scrofa (P08001), Ovis aries (Q9GL10)
Rosatti, M.I.; Beconi, M.T.; Cordoba, M.
Proacrosin-acrosin activity in capacitated and acrosome reacted sperm from cryopreserved bovine semen
Biocell
28
311-316
2004
Bos taurus
Langlois, M.R.; Oorlynck, L.; Vandekerckhove, F.; Criel, A.; Bernard, D.; Blaton, V.
Discrepancy between sperm acrosin activity and sperm morphology: significance for fertilization in vitro
Clin. Chim. Acta
351
121-129
2005
Homo sapiens
Chaudhury, K.; Das, T.; Chakravarty, B.; Bhattacharyya, A.K.
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility
Fertil. Steril.
83
104-109
2005
Homo sapiens
Furlong, L.I.; Harris, J.D.; Vazquez-Levin, M.H.
Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC
Fertil. Steril.
83
1780-1790
2005
Homo sapiens
Furlong, L.I.; Veaute, C.; Vazquez-Levin, M.H.
Binding of recombinant human proacrosin/acrosin to zona pellucida glycoproteins. II. Participation of mannose residues in the interaction
Fertil. Steril.
83
1791-1796
2005
Homo sapiens
Gupta, G.; Jain, R.K.; Maikhuri, J.P.; Shukla, P.K.; Kumar, M.; Roy, A.K.; Patra, A.; Singh, V.; Batra, S.
Discovery of substituted isoxazolecarbaldehydes as potent spermicides, acrosin inhibitors and mild anti-fungal agents
Hum. Reprod.
20
2301-2308
2005
Homo sapiens
Gaboriau, D.; Howes, E.A.; Clark, J.; Jones, R.
Binding of sperm proacrosin/beta-acrosin to zona pellucida glycoproteins is sulfate and stereodependent. Synthesis of a novel fertilization inhibitor
Dev. Biol.
306
646-657
2007
Sus scrofa
Emokpae, M.A.; Uadia, P.O.
Acrosin activity in spermatozoa of infertile Nigerian males
Indian J. Clin. Biochem.
21
199-201
2006
Homo sapiens
Raterman, D.; Springer, M.S.
The molecular evolution of acrosin in placental mammals
Mol. Reprod. Dev.
75
1196-1207
2008
Canis lupus familiaris, Macaca mulatta, Amblysomus hottentotus (B0LM06), Echinops telfairi (B0LM07), Procavia capensis (B0LM08), Elephantulus edwardii (B0LM09), Galegeeska rufescens (B0LM10), Macroscelides proboscideus (B0LM11), Loxodonta africana (B0LM12), Dugong dugon (B0LM13), Trichechus manatus (B0LM14), Orycteropus afer (B0LM15), Bradypus tridactylus (B0LM16), Euphractus sexcinctus (B0LM17), Felis catus (B0LM18), Puma concolor (B0LM19), Tursiops truncatus (B0LM20), Lama glama (B0LM21), Tragelaphus angasii (B0LM22), Tadarida brasiliensis (B0LM23), Sorex cinereus (B0LM24), Talpa europaea (B0LM25), Diceros bicornis (B0LM26), Equus caballus (B0LM27), Tapirus pinchaque (B0LM28), Manis sp. DMR-2008 (B0LM29), Cynocephalus volans (B0LM30), Tupaia glis (B0LM31), Ochotona princeps (B0LM32), Sylvilagus floridanus (B0LM33), Pan troglodytes (B0LM34), Hystrix brachyura (B0LM35), Erethizon dorsatum (B0LM36), Rattus fuscipes (B0LM37), Otospermophilus beecheyi (B0LM38), Sus scrofa (P08001), Homo sapiens (P10323), Homo sapiens, Rattus norvegicus (P29293), Oryctolagus cuniculus (P48038), Bos taurus (P79343), Mus musculus (Q3ZB05), Cavia porcellus (Q60491), Ovis aries (Q9GL10)
Veaute, C.; Furlong, L.I.; Bronson, R.; Harris, J.D.; Vazquez-Levin, M.H.
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities
Fertil. Steril.
91
1245-1255
2009
Homo sapiens
Veaute, C.; Furlong, L.I.; Cameo, M.; Harris, J.D.; Vazquez-Levin, M.H.
Antiacrosin antibodies and infertility. II. Gene immunization with human proacrosin to assess the effect of immunity toward proacrosin/acrosin upon protein activities and animal fertility
Fertil. Steril.
91
1256-1268
2009
Homo sapiens
Aquila, S.; Guido, C.; Santoro, A.; Perrotta, I.; Laezza, C.; Bifulco, M.; Sebastiano, A.
Human sperm anatomy: ultrastructural localization of the cannabinoid1 receptor and a potential role of anandamide in sperm survival and acrosome reaction
Anat. Rec. (Hoboken)
293
298-309
2010
Homo sapiens
Psenicka, M.; Vancova, M.; Koubek, P.; Tesitel, J.; Linhart, O.
Fine structure and morphology of sterlet (Acipenser ruthenus L. 1758) spermatozoa and acrosin localization
Anim. Reprod. Sci.
111
3-16
2009
Acipenser ruthenus, Acipenser ruthenus 1758
Davidova, N.; Jonakova, V.; Manaskova-Postlerova, P.
Expression and localization of acrosin inhibitor in boar reproductive tract
Cell Tissue Res.
338
303-311
2009
Sus scrofa
Yin, L.; Hang, T.; Zhang, Z.
Determination of 4-carbomethoxyphenyl 4-guanidinobenzoate mesylate by HPLC and identification of its related substances by LC-MS-MS
J. Chromatogr. Sci.
47
872-876
2009
Homo sapiens
De los Reyes, M.; Medina, G.; Palomino, J.
Western blot analysis of proacrosin/acrosin in frozen dog sperm during in vitro capacitation
Reprod. Domest. Anim.
44 Suppl 2
350-353
2009
Canis lupus familiaris
Qi, J.; Zhu, J.; Liu, X.; Ding, L.; Zheng, C.; Han, G.; Lv, J.; Zhou, Y.
Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives
Bioorg. Med. Chem. Lett.
21
5822-5825
2011
Homo sapiens
Ding, L.; Zhu, J.; Zheng, C.; Sheng, C.; Qi, J.; Liu, X.; Han, G.; Zhao, J.; Lv, J.; Zhou, Y.
Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives
Bioorg. Med. Chem. Lett.
21
6674-6677
2011
Homo sapiens
Jiang, J.; Liu, X.; Zhen, C.; Zhou, Y.; Zhu, J.; Lv, J.; Sheng, C.
Acrosin structure-based design, synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors
Chin. Chem. Lett.
22
272-275
2011
Homo sapiens
-
Slowinska, M.; Olczak, M.; Liszewska, E.; Watorek, W.; Ciereszko, A.
Isolation, characterization and cDNA sequencing of acrosin from turkey spermatozoa
Comp. Biochem. Physiol. B
157
127-136
2010
Meleagris gallopavo (Q2UVH8), Meleagris gallopavo
Liu, X.; Dong, G.; Zhang, J.; Qi, J.; Zheng, C.; Zhou, Y.; Zhu, J.; Sheng, C.; Lue, J.
Discovery of novel human acrosin inhibitors by virtual screening
J. Comput. Aided Mol. Des.
25
977-985
2011
Homo sapiens
Sasanami, T.; Yoshizaki, N.; Dohra, H.; Kubo, H.
Sperm acrosin is responsible for the sperm binding to the egg envelope during fertilization in Japanese quail (Coturnix japonica)
Reproduction
142
267-276
2011
Coturnix japonica
Liu, X.; Chen, Q.; Zhu, J.; Fan, Y.; Ding, L.; Zhao, J.; Han, G.; Tian, W.; Qi, J.; Zhou, Y.; Lv, J.
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H-benzo[d]imidazol-2-yl carbamate derivatives
Bioorg. Med. Chem. Lett.
22
3554-3559
2012
Homo sapiens
Zhao, J.; Tian, W.; Qi, J.; Lv, D.; Liu, Y.; Jiang, Y.; Dong, G.; Chen, Q.; Zhou, Y.; Zhu, J.; Wang, H.; Sheng, C.; Lv, J.
Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors
Bioorg. Med. Chem. Lett.
24
2802-2806
2014
Homo sapiens
Ferrer, M.; Rodriguez, H.; Zara, L.; Yu, Y.; Xu, W.; Oko, R.
MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization
Cell Tissue Res.
349
881-895
2012
Bos taurus
Chen, Q.; Tian, W.; Han, G.; Qi, J.; Zheng, C.; Zhou, Y.; Ding, L.; Zhao, J.; Zhu, J.; Lv, J.; Sheng, C.
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping
Eur. J. Med. Chem.
59
176-182
2013
Homo sapiens
Slowinska, M.; Ciereszko, A.
Identification of the second form of acrosin in Turkey spermatozoa
Reprod. Domest. Anim.
47
849-855
2012
Meleagris gallopavo
Perez Aguirreburualde, M.S.; Fernandez, S.; Cordoba, M.
Acrosin activity regulation by protein kinase C and tyrosine kinase in bovine sperm acrosome exocytosis induced by lysophosphatidylcholine
Reprod. Domest. Anim.
47
915-920
2012
Bos taurus
Slowinska, M.; Liszewska, E.; Dietrich, G.J.; Ciereszko, A.
Characterization of proacrosin/acrosin system after liquid storage and cryopreservation of turkey semen (Meleagris gallopavo)
Theriogenology
78
1065-1077
2012
Meleagris gallopavo
Zhang, G.; Yang, W.; Zou, P.; Jiang, F.; Zeng, Y.; Chen, Q.; Sun, L.; Yang, H.; Zhou, N.; Wang, X.; Liu, J.; Cao, J.; Zhou, Z.; Ao, L.
Mitochondrial functionality modifies human sperm acrosin activity, acrosome reaction capability and chromatin integrity
Hum. Reprod.
34
3-11
2019
Homo sapiens
Xu, F.; Zhu, H.; Zhu, W.; Fan, L.
Human sperm acrosomal status, acrosomal responsiveness, and acrosin are predictive of the outcomes of in vitro fertilization A prospective cohort study
Reprod. Biol.
18
344-354
2018
Homo sapiens
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