Reference on EC 3.4.17.3 - lysine carboxypeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, W.; Hendricks, D.F.; Scharpe, S.S.
Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen
J. Biol. Chem.
269
15937-15944
1994
Homo sapiens
Homandberg, G.A.; Peanasky, R.J.
Characterization of proteins from Ascaris lumbricoides which bind specifically to carboxypeptidase
J. Biol. Chem.
251
2226-2233
1976
Saccharomyces cerevisiae
Ryan, J.
Arginine carboxypeptidase and its inhibitors
Methods Enzymol.
163
186-194
1988
Homo sapiens
Skidgel, R.A.; Erdös, E.G.
Carboxypeptidase N (arginine carboxypeptidase)
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
60-72
1984
Homo sapiens
-
Plummer, T.H.; Erdös, E.G.
Human plasma carboxypeptidase N
Methods Enzymol.
80
442-449
1981
Homo sapiens
Plummer, T.H.; Hurwitz, M.Y.
Human plasma carboxypeptidase N. Isolation and characterization
J. Biol. Chem.
253
3907-3912
1978
Homo sapiens
Fricker, L.D.; Plummer, T.H.; Snyder, S.H.
Enkephalin convertase: potent, selective, and irreversible inhibitors
Biochem. Biophys. Res. Commun.
111
994-1000
1983
Homo sapiens
Tan, F.; Weerasinghe, D.K.; Skidgel, R.A.; Tamei, H.; Kaul, R.K.; Roninson, I.B.; Schilling, J.W.; Erdös, E.G.
The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats [published erratum appears in J Biol Chem 1990 Jul 25;265(21):12749
J. Biol. Chem.
265
13-19
1990
Homo sapiens
Levin, Y.; Skidgel, R.A.; Erdös, E.G.
Isolation and characterization of the subunits of human plasma carboxypeptidase N (kininase i)
Proc. Natl. Acad. Sci. USA
79
4618-4622
1982
Homo sapiens
Oshima, G.; Kato, J.; Erdös, E.G.
Plasma carboxypeptidase N, subunits and characteristics
Arch. Biochem. Biophys.
170
132-138
1975
Homo sapiens
Oshima, G.; Kato, J.; Erdös, E.G.
Subunits of human plasma carboxypeptidase N (kininase I, anaphylatoxin inactivator)
Biochim. Biophys. Acta
365
344-348
1974
Homo sapiens, Sus scrofa
-
Hendriks, D.; Scharpe, S.; van Sande, M.
Carboxypeptidase N activity in human tissues and fluids
Biochem. Soc. Trans.
14
1048
1986
Homo sapiens
-
Grimwood, B.G.; Plummer, T.H.; Tarentino, A.L.
Characterization of the carboxypeptidase N secreted by Hep G2 cells
J. Biol. Chem.
263
14397-14401
1988
Homo sapiens
Jeanneret, L.; Roth, M.; Bargetzi, J.P.
Carboxypeptidase N from pig serum
Hoppe-Seyler's Z. Physiol. Chem.
357
867-872
1976
Sus scrofa
Juillerat-Jeanneret, L.; Roth, M.; Bargetzi, J.P.
Some properties of porcine carboxypeptidase N
Hoppe-Seyler's Z. Physiol. Chem.
363
51-58
1982
BRENDA: Sus scrofa
Textmining: Homo sapiens
Moriguchi, M.; Umeda, Y.; Miyazaki, K.; Nakamura, T.; Ogawa, K.; Kojima, F.; Iinuma, H.; Aoyagi, T.
Synthesis of histargin and related compounds and their inhibition of enzymes
J. Antibiot.
41
1823-1827
1988
Homo sapiens
Gebhard, W.; Schube, M.; Eulitz, M.
cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)
Eur. J. Biochem.
178
603-607
1989
BRENDA: Homo sapiens
Textmining: Bos taurus
Plummer, T.H.; Kimmel, M.T.
An improved spectrophotometric assay for human plasma carboxypeptidase N1
Anal. Biochem.
108
348-353
1980
Homo sapiens
Hendriks, D.; Scharpe, S.; van Sande, M.
Assay of carboxypeptidase N activity in serum by liquid-chromatographic determination of hippuric acid
Clin. Chem.
31
1936-1939
1985
Homo sapiens
Koheil, A.; Forstner, G.
Isoelectric focusing of carboxypeptidase N
Biochim. Biophys. Acta
524
156-161
1978
Homo sapiens
Skidgel, R.A.; Weerasinghe, D.K.; Erdös, E.G.
Structure of human carboxypeptidase N (kininase I)
Adv. Exp. Med. Biol.
247A
325-329
1989
Homo sapiens
Linder, L.E.; Sund, M.L.; Lönnies, H.
Isolation and purification of cell wall-associated arginine carboxypeptidase from Streptococcus mitis ATCC 15909
Curr. Microbiol.
28
91-96
1994
Streptococcus mitis
-
Wang, W.; Hendriks, D.F.; Scharpe, S.L.
Immobilized carboxypeptidase N. A potent bioreactor and specific adsorbent for peptides
Appl. Biochem. Biotechnol.
44
151-160
1994
Homo sapiens
McCleave, M.J.; Elliott, R.J.; Archbold, G.P.
Human plasma carboxypeptidase N; stability of enzyme activity following collection
Biochem. Soc. Trans.
24
42S
1996
BRENDA: Homo sapiens
Textmining: collection
Barabe, J.; Huberdeau, D.
A micromethod for the determination of the activities of kininases in rat plasma. Kinetics and inhibitory characteristics
Biochem. Pharmacol.
41
821-827
1991
BRENDA: Rattus norvegicus
Textmining: Rattus
Orawski, A.T.; Susz, J.P.; Simmons, W.H.
Metabolism of bradykinin by multiple coexisting membrane-bound peptidases in lung: techniques for investigating the role of each peptidase using specific inhibitors
Adv. Exp. Med. Biol.
247B
355-364
1989
Bos taurus, Rattus norvegicus
Schweisfurth, H.
Carboxypeptidase N
Dtsch. Med. Wochenschr.
109
1254-1258
1984
Homo sapiens
Yoshida, T.; Nosaka, S.
Some characteristics of a peptidyl dipeptidase (kininase II) from rat CSF: differential effects of NaCl on the sequential degradation steps of bradykinin
J. Neurochem.
55
1861-1869
1990
Rattus
Grimwood, B.G.; Plummer, T.H.; Tarentino, A.L.
Carboxypeptidase H. A regulatory peptide-processing enzyme produced by human hepatoma Hep G2 cells
J. Biol. Chem.
264
15662-15667
1989
Homo sapiens
Deddish, P.A.; Skidgel, R.A.; Erdös, E.G.
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase)
Biochem. J.
261
289-291
1989
Homo sapiens
Skidgel, R.A.; Davis, R.M.; Tan, F.
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormones
J. Biol. Chem.
264
2236-2241
1989
Homo sapiens
Deddish, P.A.; Skidgel, R.A.; Kriho, V.B.; Li, X.Y.; Becker, R.P.; Erd÷s, E.G.
Carboxypeptidase M in Madin-Darby canine kidney cells. Evidence that carboxypeptidase M has a phosphatidylinositol glycan anchor
J. Biol. Chem.
265
15083-15089
1990
Homo sapiens
Lazoura, E.; Campbell, W.; Yamaguchi, Y.; Kato, K.; Okada, N.; Okada, H.
Rational structure-based design of a novel carboxypeptidase R inhibitor
Chem. Biol.
9
1129-1139
2002
Homo sapiens
Sato, T.; Miwa, T.; Akatsu, H.; Matsukawa, N.; Obata, K.; Okada, N.; Campbell, W.; Okada, H.
Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not
J. Immunol.
165
1053-1058
2000
BRENDA: Mus musculus (Q9JJN5), Mus musculus
Textmining: Solanum tuberosum, Homo sapiens
Suzuki, K.; Muto, Y.; Fushihara, K.; Kanemoto, K.; Iida, H.; Sato, E.; Kikuchi, C.; Matsushima, T.; Kato, E.; Nomoto, M.; Yoshioka, S.; Ishii, H.
Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxypho sphinoyl] methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B
J. Pharmacol. Exp. Ther.
309
607-615
2004
Homo sapiens, Rattus norvegicus
Kato, T.; Akatsu, H.; Sato, T.; Matsuo, S.; Yamamoto, T.; Campbell, W.; Hotta, N.; Okada, N.; Okada, H.
Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N
Microbiol. Immunol.
44
719-728
2000
BRENDA: Rattus norvegicus
Textmining: Rattus
Campbell, W.D.; Lazoura, E.; Okada, N.; Okada, H.
Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N
Microbiol. Immunol.
46
131-134
2002
Homo sapiens
Komura, H.; Shimomura, Y.; Yumoto, M.; Katsuya, H.; Okada, N.; Okada, H.
Heat stability of carboxypeptidase R of experimental animals
Microbiol. Immunol.
46
217-223
2002
BRENDA: Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Textmining: Metazoa, Rattus, animal
Quagraine, M.O.; Tan, F.; Tamei, H.; Erdoes, E.G.; Skidgel, R.A.
Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N
Biochem. J.
388
81-91
2005
Homo sapiens
Davis, D.A.; Singer, K.E.; De La Luz Sierra, M.; Narazaki, M.; Yang, F.; Fales, H.M.; Yarchoan, R.; Tosato, G.
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation
Blood
105
4561-4568
2005
Homo sapiens
Matthews, K.W.; Drouin, S.M.; Liu, C.; Martin, J.F.; Skidgel, R.A.; Wetsel, R.A.
Expression of the third complement component (C3) and carboxypeptidase N small subunit (CPN1) during mouse embryonic development
Dev. Comp. Immunol.
28
647-655
2004
Mus musculus
Matthews, K.W.; Mueller-Ortiz, S.L.; Wetsel, R.A.
Carboxypeptidase N: a pleiotropic regulator of inflammation
Mol. Immunol.
40
785-793
2004
Homo sapiens, Mus musculus
Leung, L.L.; Nishimura, T.; Myles, T.
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)
Adv. Exp. Med. Biol.
632
61-69
2008
BRENDA: Mus musculus
Textmining: Mus sp.
Du, X.Y.; Zabel, B.A.; Myles, T.; Allen, S.J.; Handel, T.M.; Lee, P.P.; Butcher, E.C.; Leung, L.L.
Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets
J. Biol. Chem.
284
751-758
2009
Homo sapiens, Homo sapiens (P15169)
Leung, L.L.; Myles, T.; Nishimura, T.; Song, J.J.; Robinson, W.H.
Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI)
Mol. Immunol.
45
4080-4083
2008
BRENDA: Mus musculus
Textmining: Mus sp.
Talens, S.; Lebbink, J.H.; Malfliet, J.J.; Demmers, J.A.; Uitte de Willige, S.; Leebeek, F.W.; Rijken, D.C.
Binding of carboxypeptidase N to fibrinogen and fibrin
Biochem. Biophys. Res. Commun.
427
421-425
2012
Homo sapiens
Li, Y.; Li, Y.; Chen, T.; Kuklina, A.S.; Bernard, P.; Esteva, F.J.; Shen, H.; Ferrari, M.; Hu, Y.
Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer
Clin. Chem.
60
233-242
2014
Mus musculus
Helwig, M.; Herwig, A.; Heldmaier, G.; Barrett, P.; Mercer, J.G.; Klingenspor, M.
Photoperiod-dependent regulation of carboxypeptidase E affects the selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus)
J. Neuroendocrinol.
25
190-197
2013
Phodopus sungorus
Leung, L.L.K.; Morser, J.
Carboxypeptidase B2 and carboxypeptidase N in the crosstalk between coagulation, thrombosis, inflammation, and innate immunity
J. Thromb. Haemost.
16
1474-1486
2018
Mus musculus (Q9JJN5)
Wu, T.Y.; Wang, Y.S.; Song, Y.C.; Chen, Z.Y.; Chen, Y.T.; Chiu, C.C.; Wu, C.Y.
Fine-tune regulation of carboxypeptidase N1 controls vascular patterning during zebrafish development
Sci. Rep.
7
1852
2017
Danio rerio (U3JB00), Danio rerio
Ito, Y; Mizutani, S; Kurauchi, O; Kasugai, M; Narita, O; Tomoda, Y
Purification and properties of microsomal carboxypeptidase N (kininase I) in human placenta.
Enzyme
42
8-14
1989
Homo sapiens
Hendriks, D; Wang, W; ScharpƩ, S; Lommaert, MP; van Sande, M
Purification and characterization of a new arginine carboxypeptidase in human serum.
Biochim Biophys Acta
1034
86-92
1990
Homo sapiens
Campbell, W; Yonezu, K; Shinohara, T; Okada, H
An arginine carboxypeptidase generated during coagulation is diminished or absent in patients with rheumatoid arthritis.
J Lab Clin Med
115
610-2
1990
Homo sapiens
Guo, X; Morioka, A; Kaneko, Y; Okada, N; Obata, K; Nomura, T; Campbell, W; Okada, H
Arginine carboxypeptidase (CPR) in human plasma determined with sandwich ELISA.
Microbiol Immunol
43
691-8
1999
Homo sapiens
Wang, DJ; Miao, L; Chen, H; Li, YY; Chen, HP; Fang, HQ
[Expression, purification and characterization of rat procarboxypeptidase B in Pichia pastoris]
Sheng Wu Gong Cheng Xue Bao
23
61-6
2007
Komagataella pastoris, Rattus
Kim, MJ; Kim, SH; Lee, JH; Seo, JH; Lee, JH; Kim, JH; Kim, YH; Nam, SW
High-level secretory expression of human procarboxypeptidase B by Fed-Batch cultivation of Pichia pastoris and its partial characterization.
J Microbiol Biotechnol
18
1938-44
2008
Homo sapiens, Pichia
Gecse, A; Ottlecz, A; Tƶrƶk, L; Telegdy, G; Morvay, J; Sas, M
Bradykininase and protease inhibitors in seminal plasma of fertile and infertile men.
Arch Androl
2
311-6
1979
Homo sapiens
Mathews, KP; Pan, PM; Amendola, MA; Lewis, FH
Plasma protease inhibitor and anaphylatoxin inactivator levels in chronic urticaria/angioedema and in patients experiencing anaphylactoid reactions to radiographic contrast media.
Int Arch Allergy Appl Immunol
79
220-3
1986
Homo sapiens
Amato, A; Porcelli, G; Volpe, AR; Cotogni, P; De Giovanni, L; Civello, IM; Butti, A
Kininase I, kininase II and aminopeptidase levels in patients with gastrointestinal tumors.
Ital J Surg Sci
17
141-6
1987
Homo sapiens
Orawski, AT; Simmons, WH
Aminopeptidase P: purification of a membrane-bound bradykininase from rat lung.
Agents Actions Suppl
38 ( Pt 1)
414-21
1992
Rattus
Trapeznikova, SS; Gontar', ID
[Interaction of immobilized carboxypeptidase with a natural inhibitor from human blood plasma]
Vopr Med Khim
840-4
0
Homo sapiens
Trapeznikova, SS; Mardashev, SR
[Isolation, purification and properties of a carboxypeptidase inhibitor from human blood serum]
Vopr Med Khim
21
417-22
0
Homo sapiens
Hendriks, D; ScharpƩ, S; van Sande, M; Lommaert, MP
Characterisation of a carboxypeptidase in human serum distinct from carboxypeptidase N.
J Clin Chem Clin Biochem
27
277-85
1989
Homo sapiens
Grimwood, BG; Tarentino, AL; Plummer, TH
High performance liquid chromatographic quantitation of carboxypeptidase activity secreted by human hep G2 cells.
Anal Biochem
170
264-8
1988
Homo sapiens
Hendriks, D; Soons, J; ScharpƩ, S; Wevers, R; van Sande, M; Holmquist, B
Identification of the carboxypeptidase responsible for the post-synthetic modification of creatine kinase in human serum.
Clin Chim Acta
172
253-60
1988
Homo sapiens
Skidgel, RA; Bennett, CD; Schilling, JW; Tan, FL; Weerasinghe, DK; Erdƶs, EG
Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases.
Biochem Biophys Res Commun
154
1323-9
1988
Homo sapiens, Bos taurus
Edwards, RJ; Watts, DC
Development of carboxypeptidase K (creatine kinase conversion factor) in man.
Clin Chim Acta
162
69-74
1987
Homo sapiens
Bokisch, VA; MĆ¼ller-Eberhard, HJ
Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase.
J Clin Invest
49
2427-36
1970
Homo sapiens
Marceau, F; Drumheller, A; Gendreau, M; Lussier, A; St-Pierre, S
Rapid assay of human plasma carboxypeptidase N by high-performance liquid chromatographic separation of hippuryl-lysine and its product.
J Chromatogr
266
173-7
1983
Homo sapiens
Skidgel, RA; Davis, RM; Erdƶs, EG
Purification of a human urinary carboxypeptidase (kininase) distinct from carboxypeptidases A, B, or N.
Anal Biochem
140
520-31
1984
Homo sapiens
Gengin, MT; Vernigora, AN
[The effect of emotional-pain stress on the activity of carboxypeptidase N--the enzyme of neuropeptide processing in the rat brain]
Fiziol Zh Im I M Sechenova
80
23-7
1994
Rattus
Skidgel, RA; Erdƶs, EG
Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator.
Int Immunopharmacol
7
1888-99
2007
Homo sapiens
Hu, X; Wetsel, RA; Ramos, TN; Mueller-Ortiz, SL; Schoeb, TR; Barnum, SR
Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.
Immunobiology
2013
Mus sp., animal
Godahewa, GI; Wickramaarachchi, WD; Whang, I; Bathige, SD; Lim, BS; Choi, CY; De Zoysa, M; Noh, JK; Lee, J
Two carboxypeptidase counterparts from rock bream (Oplegnathus fasciatus): molecular characterization, genomic arrangement and immune responses upon pathogenic stresses.
Vet Immunol Immunopathol
162
180-91
2014
Abramis brama
Skidgel, RA; Deddish, PA; Davis, RM
Isolation and characterization of a basic carboxypeptidase from human seminal plasma.
Arch Biochem Biophys
267
660-7
1988
Homo sapiens
Blass, J; Verriest, C; Vicaigne, MB; Weiss, M
["In vitro" protaminase activity of human plasma and serum and the human carboxypeptidase N (author's transl)]
Pathol Biol (Paris)
28
527-34
1980
Homo sapiens
Overturf, M; Wyatt, S; Boaz, D; Fitz, A
Angiotensin I [Phe8-His9] hydrolase and bradykininase from human lung.
Life Sci
16
1669-81
1975
Homo sapiens
Paskhina, TS; Traleznikova, SS; Egorovoa, TL; Morozova, NA
[Effect of bradkinin-potentiating snake venom peptides and C-terminal pentapeptide fragment of bradkinin on carboxypeptidase N and kiniase activities of human blood serum]
Biokhimiia
40
844-53
0
Homo sapiens, snake, Bothrops jararaca, Gloydius blomhoffii, Rattus
RybƔk, M; Mansfeld, V; GrimovƔ, J; PetƔkovƔ, M
Effect of carboxypeptidase N, aprotinin and anti-inflammatory drugs of pyrazolidine type on experimental inflammations in rats.
Pharmacology
16
11-6
1978
Rattus
Nakashizuka, T; Omori, H; Mizuno, K; Mizuno, Y; Ito, H; Yamada, H
[The variation of bradykininase activity in the pocket exudate of the patients with periodontal disease after scaling and brushing (author's transl)]
Nippon Shishubyo Gakkai Kaishi
21
173-82
1979
Homo sapiens
PetƔkovƔ, M; SimonianovƔ, E; RybƔk, M
[Determination and preparation of carboxypeptidase N (kininase) and kallikrein (kininogenase) from the euglobulin fraction of human serum]
Cesk Farm
27
442-4
1978
Homo sapiens
Hendriks, D; Vingron, M; Vriend, G; Wang, W; Nalis, D; ScharpƩ, S
Comparative molecular modeling of the active subunit of human kininase I.
Agents Actions Suppl
38 ( Pt 1)
368-75
1992
Homo sapiens
Vernigora, AN; Gengin, MT
[The subcellular localization of carboxypeptidase N in the substantia grisea of the cat brain]
Ukr Biokhim Zh
64
98-101
0
Felis catus
Vernigora, AN; Gengin, MT; Nikishin, NN
[Purification and physico-chemical properties of soluble carboxypeptidase N from cat brain gray matter]
Biokhimiia
57
1712-9
1992
Felis catus
Rabito, SF; Anders, R; Soden, W; Skidgel, RA
Carboxypeptidase N concentration during cardiopulmonary bypass in humans.
Can J Anaesth
39
54-9
1992
Homo sapiens
Huberdeau, D; BarabƩ, J
[Activity of plasma kininase I and kininase II in hypertensive rats]
Arch Mal Coeur Vaiss
83
1321-4
1990
Metazoa, Rattus, Rattus norvegicus
Oza, NB; Schwartz, JH; Goud, HD; Levinsky, NG
Rat aortic smooth muscle cells in culture express kallikrein, kininogen, and bradykininase activity.
J Clin Invest
85
597-600
1990
Rattus, Glycine max, Canis lupus familiaris
Ogata, H; Ura, N; Shimamoto, K; Sakakibara, T; Ando, T; Nishimiya, T; Nakagawa, M; Fukuyama, S; Masuda, A; Yamaguchi, Y
A sensitive method for differential determination of kininase I, II and neutral endopeptidase (NEP) in human urine.
Adv Exp Med Biol
247B
343-8
1989
Homo sapiens
Dayer, JM; Hampai, A; Schmidt, M; Winistƶrfer, B; Mirkovitch, V; Roth, M
Recombinant human interleukin-1 beta decreases serum carboxypeptidase N and modifies serum amino acid concentrations in rats.
Exp Mol Pathol
50
362-70
1989
Homo sapiens, Rattus, Rattus norvegicus
Hendriks, D; ScharpƩ, S; van Sande, M; Lommaert, MP
A labile enzyme in fresh human serum interferes with the assay of carboxypeptidase N.
Clin Chem
35
177
1989
Homo sapiens
Kononenko, VIa; Kalinskaia, LN; Iakovlev, AA
[Effect of hydrocortisone on the activity of angiotensin-converting and renin-like enzymes and kininase I in the brain and hypophysis of rats]
Probl Endokrinol (Mosk)
32
72-5
0
Rattus
Schweisfurth, H; Schmidt, M; Reinhart, E; Brugger, E
Kininase I and II activities in serum of patients with lung diseases.
Adv Exp Med Biol
198 Pt B
439-42
1986
Homo sapiens
Porcelli, G; Di Iorio, M; Volpe, AR
Determination of kininase I and kininase II activities in human urine by high-performance liquid chromatography.
J Chromatogr
414
423-8
1987
Homo sapiens
Kononenko VYa, ; Kalinskaya, LN; Yakovlev, AA
Effect of hydrocortisone on the activity of the angiotensin-converting and renin-like enzymes and kininase I in rat brain and hypophysis.
Neurosci Behav Physiol
17
40-2
0
Rattus
Chercuitte, F; Beaulieu, AD; Poubelle, P; Marceau, F
Carboxypeptidase N (kininase I) activity in blood and synovial fluid from patients with arthritis.
Life Sci
41
1225-32
1987
Homo sapiens, Indicator
Michelutti, L; Falter, H; Certossi, S; Marcotte, B; Mazzuchin, A
Isolation and purification of creatine kinase conversion factor from human serum and its identification as carboxypeptidase N.
Clin Biochem
20
21-9
1987
Homo sapiens
Hendriks, D; ScharpƩ, S; Van Camp, K; van Sande, M
Kininase I activity in human fluids and tissues of the urogenital tract.
Urol Int
42
94-5
1987
Homo sapiens
Abendschein, DR; Serota, H; Plummer, TH; Amiraian, K; Strauss, AW; Sobel, BE; Jaffe, AS
Conversion of MM creatine kinase isoforms in human plasma by carboxypeptidase N.
J Lab Clin Med
110
798-806
1987
Homo sapiens
Vallota, EH; MĆ¼ller-Eberhard, HJ
Formation of C3a and C5a anaphylatoxins in whole human serum after inhibition of the anaphylatoxin inactivator.
J Exp Med
137
1109-23
1973
Homo sapiens
Mizuno, K
[Kinin contents and bradykininase activities in whole saliva and ginival fluid from patients with periodontal disease (author's transl)]
Nippon Shishubyo Gakkai Kaishi
16
140-9
1974
Homo sapiens
Alabaster, VA; Bakhle, YS
The bradykininase activities of extracts of dog lung.
Br J Pharmacol
47
799-807
1973
Canis lupus familiaris
Mitsui, S; Takano, T
[Bradykininase activity in human plasma and its dynamic activity in asthmatic patients]
Arerugi
19
640-3
1970
Homo sapiens
Shimonaeva, EE
[On some properties of carboxypeptidase N from rabbit blood serum]
Vopr Med Khim
13
105-7
0
Oryctolagus cuniculus
Bokisch, VA; MĆ¼ller-Eberhard, HJ; Cochrane, CG
Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum.
J Exp Med
129
1109-30
1969
Homo sapiens
Sicuteri, F; Fanciullacci, M; Del Bianco, PL; Anselmi, B
[Bradykininase in the cerebrospinal fluid of humans]
Boll Soc Ital Biol Sper
41
464-7
1965
Homo sapiens
Schweisfurth, H; Reinhart, E; Heinrich, J; Brugger, E
A simple spectrophotometric assay of carboxypeptidase N (kininase I) in human serum.
J Clin Chem Clin Biochem
21
605-9
1983
Homo sapiens
Moshchich, PS; Kramarev, SA; Blonskaia, LF; Dishchuk, II; Mrinskaia, NI
[Value of studying carboxypeptidase N activity in the blood and urine of children with viral hepatitis]
Pediatriia
40-1
1983
Homo sapiens
Schweisfurth, H; Heinrich, J; Brugger, E; Burghardt, W
[Changes in serum carboxypeptidase N in patients with lung sarcoidosis]
Dtsch Med Wochenschr
109
166-9
1984
Homo sapiens
Adome, RO
Escherichia coli endotoxin and cat plasma bradykininase.
Indian J Physiol Pharmacol
26
181-2
0
Escherichia coli, Felis catus
Mielens, ZE; Fairbairn, ME; Patrick, RA
Serum levels of anaphylatoxin inactivator in intrinsic asthmatic patients.
J Asthma
19
171-5
1982
Homo sapiens
Plummer, TH; Ryan, TJ
A potent mercapto bi-product analogue inhibitor for human carboxypeptidase N.
Biochem Biophys Res Commun
98
448-54
1981
Homo sapiens
Vernigora, AN; Gengin, MT; Nikishin, NN; Shchetinina, NV
[Carboxypeptidase N and angiotensin-converting enzyme activities in the blood serum of rats with different resistances to emotional stress]
Fiziol Zh Im I M Sechenova
80
23-6
1994
Rattus
Nikishin, NN; Vernigora, AN; Gengin, MT
[The effect of diazepam on the activity of carboxypeptidase N and the angiotensin-converting enzyme in sections of the brain of rats with differing normal emotionality and in emotional stress]
Fiziol Zh Im I M Sechenova
80
108-13
1994
Rattus
Skidgel, RA
Human carboxypeptidase N: lysine carboxypeptidase.
Methods Enzymol
248
653-63
1995
Homo sapiens
Gengin, MT; Vernigora, AN; Nikishin, NN; Shchetinina, NV
[Carboxypeptidase N and angiotensin converting enzyme activity in rat blood serum in health and during emotional stress]
Ukr Biokhim Zh
66
116-9
0
Rattus
Vernigora, AN; Gengin, MT
[The effect of alcohol consumption on carboxypeptidase N activity in rat brain during chronic emotional-painful stress]
Vopr Med Khim
39
40-2
0
Hippocampus, Rattus
Pineau, P; Marchio, A; Terris, B; Mattei, MG; Tu, ZX; Tiollais, P; Dejean, A
A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus.
J Virol
70
7280-4
1996
Hepatitis B virus, Homo sapiens, Transformation
Riley, DA; Tan, F; Miletich, DJ; Skidgel, RA
Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1).
Genomics
50
105-8
1998
Homo sapiens
Kuoppala, A; Lindstedt, KA; Saarinen, J; Kovanen, PT; Kokkonen, JO
Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma.
Am J Physiol Heart Circ Physiol
278
H1069-74
2000
Homo sapiens
Matthews, KW; Wetsel, RA
Characterization of mouse carboxypeptidase N small active subunit gene structure.
J Immunol
166
6196-202
2001
Mus musculus, Homo sapiens
Keil, C; Maskos, K; Than, M; Hoopes, JT; Huber, R; Tan, F; Deddish, PA; Erdƶs, EG; Skidgel, RA; Bode, W
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.
J Mol Biol
366
504-16
2007
Homo sapiens
Solov'ev, VB; Gengin, MT
[Activity of peptidyl-dipeptidase A and carboxypeptidase N in the serum of patients with Alzheimer disease]
Ukr Biokhim Zh
79
106-8
0
Homo sapiens
Mueller-Ortiz, SL; Wang, D; Morales, JE; Li, L; Chang, JY; Wetsel, RA
Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock.
J Immunol
182
6533-9
2009
Mus musculus, Mus sp.
Gengin, MT; Solov'ev, VB; Smetanin, VA; Pazialova, AA; Simkina, OV; Konovalov, AN; Kuzichkin, DS; Shashkina, NK; Gengina, NM; Subbotina, KB
[Atropine effect on activity of angiotensin-converting enzyme and carboxypeptidase n in the serum of rats]
Ukr Biokhim Zh
77
94-6
2005
Rattus
Suda, H; Yamauchi, H; Iso, T
[Potentiative effects of angiotensin converting enzyme inhibitors on carrageenan-induced edema in rats]
Nippon Yakurigaku Zasshi
80
517-23
1982
Rattus
Arbin, V; Claperon, N; FourniƩ-Zaluski, MC; Roques, BP; Peyroux, J
Effects of combined neutral endopeptidase 24-11 and angiotensin-converting enzyme inhibition on femoral vascular conductance in streptozotocin-induced diabetic rats.
Br J Pharmacol
130
1297-304
2000
Rattus
Sivieri, DO; Bispo-da-Silva, LB; Oliveira, EB; Resende, AC; Salgado, MC
Potentiation of bradykinin effect by angiotensin-converting enzyme inhibition does not correlate with angiotensin-converting enzyme activity in the rat mesenteric arteries.
Hypertension
50
110-5
2007
Rattus
Brusco, I; Justino, AB; Silva, CR; Scussel, R; Machado-de-Įvila, RA; Oliveira, SM
Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice.
Eur J Pharmacol
895
173870
2021
Mus sp.
Tan, F; Chan, SJ; Steiner, DF; Schilling, JW; Skidgel, RA
Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.
J Biol Chem
264
13165-70
1989
Homo sapiens, Bos taurus
Xin, X; Day, R; Dong, W; Lei, Y; Fricker, LD
Cloning, sequence analysis, and distribution of rat metallocarboxypeptidase Z.
DNA Cell Biol
17
311-9
1998
Rattus, Homo sapiens
Wiggins, RC; Giclas, PC; Henson, PM
Chemotactic activity generated from the fifth component of complement by plasma kallikrein of the rabbit.
J Exp Med
153
1391-404
1981
Oryctolagus cuniculus, Glycine max
Hecquet, C; Tan, F; Marcic, BM; Erdƶs, EG
Human bradykinin B(2) receptor is activated by kallikrein and other serine proteases.
Mol Pharmacol
58
828-36
2000
Homo sapiens, Sus scrofa
Billadello, JJ; Fontanet, HL; Strauss, AW; Abendschein, DR
Characterization of MB creatine kinase isoform conversion in vitro and in vivo in dogs.
J Clin Invest
83
1637-43
1989
Canis lupus familiaris
Michel, B; IgiÄ, R; Leray, V; Deddish, PA; Erdƶs, EG
Removal of Arg141 from the alpha chain of human hemoglobin by carboxypeptidases N and M.
Circ Res
78
635-42
1996
Homo sapiens, Rattus
Kaminishi, H; Tanaka, M; Cho, T; Maeda, H; Hagihara, Y
Activation of the plasma kallikrein-kinin system by Candida albicans proteinase.
Infect Immun
58
2139-43
1990
Candida albicans, Glycine max, Saccharomyces cerevisiae, Cavia, Zea mays subsp. mays
Proud, D; Subauste, MC; Ward, PE
Glucocorticoids do not alter peptidase expression on a human bronchial epithelial cell line.
Am J Respir Cell Mol Biol
11
57-65
1994
Homo sapiens
Vieira, MA; Moreira, MF; Maack, T; GuimarĆ£es, JA
Conversion of T-kinin to bradykinin by the rat kidney.
Biochem Pharmacol
47
1693-9
1994
Rattus, Cavia porcellus
Pesquero, JB; Jubilut, GN; Lindsey, CJ; Paiva, AC
Bradykinin metabolism pathway in the rat pulmonary circulation.
J Hypertens
10
1471-8
1992
Rattus
ScharpƩ, SL; Vanhoof, GC; De Meester, IA; Hendriks, DF; van Sande, ME; Muylle, LM; Yaron, A
Exopeptidases in human platelets: an indication for proteolytic modulation of biologically active peptides.
Clin Chim Acta
195
125-31
1991
Homo sapiens, Lethrinidae
Dendorfer, A; Wolfrum, S; Wagemann, M; Qadri, F; Dominiak, P
Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats.
Am J Physiol Heart Circ Physiol
280
H2182-8
2001
Rattus
Cyr, M; Lepage, Y; Blais, C; Gervais, N; Cugno, M; Rouleau, JL; Adam, A
Bradykinin and des-Arg(9)-bradykinin metabolic pathways and kinetics of activation of human plasma.
Am J Physiol Heart Circ Physiol
281
H275-83
2001
Homo sapiens
Székįcs, B; Vįrbķró, S; Debreczeni, L
High-dose ACEi might be harmful in COVID-19 patients with serious respiratory distress syndrome by leading to excessive bradykinin receptor activation.
Physiol Int
2021
Severe acute respiratory syndrome coronavirus 2
Ishida, H; Scicli, AG; Carretero, OA
Contributions of various rat plasma peptidases to kinin hydrolysis.
J Pharmacol Exp Ther
251
817-20
1989
Rattus
Morichi, S; Izaka, K
Some components of the kinin system in Cohn's unheated human plasma proteins.
Transfusion
16
178-81
0
Homo sapiens
Majima, M; Jin, HY; Katori, M; Sunahara, N
Increase in the kinin levels in the bronchial washings after intravenous injection of leukotriene C4 in guinea pigs.
Agents Actions Suppl
38 ( Pt 3)
467-74
1992
Cavia, Cavia porcellus
Paskhina, TS; Poliantseva, LR; Platonova, LV; Levina, GO
[Components of kallikrein-kinin system in the urine of patients with glomerulonephritis]
Vopr Med Khim
36
62-9
0
Homo sapiens
Ichinose, M; Barnes, PJ
The effect of peptidase inhibitors on bradykinin-induced bronchoconstriction in guinea-pigs in vivo.
Br J Pharmacol
101
77-80
1990
Cavia
Konno, S; Tsurufuji, S
Inability of rat anaphylatoxin to induce histamine release in rats.
Jpn J Pharmacol
38
185-93
1985
Rattus
Stimler-Gerard, NP
Neutral endopeptidase-like enzyme controls the contractile activity of substance P in guinea pig lung.
J Clin Invest
79
1819-25
1987
Cavia porcellus
Assreuy, J; Almeida, AA; GuimarĆ£es, JA
Pharmacological properties of a new kinin-potentiating peptide generated from human serum proteins.
Eur J Pharmacol
168
231-7
1989
Rattus, Cavia porcellus, Chelator
Fernandez-Gallardo, S; Gijon, MA; Furio, V; Vivanco, F; Crespo, MS
Role of complement-derived peptides in thrombocytopenia elicited by soluble aggregates of immunoglobulin G in the rat.
Lab Invest
60
705-13
1989
Rattus
Kumakura, S; Kamo, I; Tsurufuji, S
Nature of kininase activity in the exudate in kaolin-induced inflammation of the air pouch type in rats.
Eur J Pharmacol
149
267-75
1988
Rattus
Minchiotti, L; Galliano, M; Iadarola, P; Meloni, ML; Ferri, G; Porta, F; Castellani, AA
The molecular defect in a COOH-terminal-modified and shortened mutant of human serum albumin.
J Biol Chem
264
3385-9
1989
Homo sapiens, Terminator
Kalinskaia, LN; Kononenko, VIa; Iakovlev, AA
[Changes in the activity of enzymes of renin-angiotensin and kinin systems in the rat brain after adrenalectomy and administration of hydrocortisone]
Ukr Biokhim Zh
57
35-40
0
Rattus
Kaminskaya, GO; Sehrt, I; Balta, NQ
Comparative study of kinin destroying activity of blood enzymes in respiratory sarcoidosis patients.
Z Erkr Atmungsorgane
166
274-80
1986
Homo sapiens
Schweisfurth, H; Pickert, E; Gramer, E; Reiners, C
Alterations of carboxypeptidases N activities in patients with thyroid dysfunction.
Clin Biochem
20
43-6
1987
Homo sapiens
Hoffmann, T; Bƶttger, EC; Baum, HP; Messner, M; Hadding, U; Bitter-Suermann, D
In vivo effects of C3a on neutrophils and its contribution to inflammatory lung processes in a guinea-pig model.
Clin Exp Immunol
71
486-92
1988
Metazoa, Cavia porcellus, Cavia
Watson, JW; Drazen, JM; Stimler-Gerard, NP
Synergism between inflammatory mediators in vivo. Induction of airway hyperresponsiveness to C3a in the guinea pig.
Am Rev Respir Dis
137
636-40
1988
Metazoa
Kumakura, S; Tsurufuji, S; Kurooka, S; Sunahara, N
Role of bradykinin generating and degrading systems in the vascular permeability response induced with kaolin in rats.
J Pharmacol Exp Ther
243
1067-73
1987
Glycine max, Rattus
Charo, IF; Yuen, C; Perez, HD; Goldstein, IM
Chemotactic peptides modulate adherence of human polymorphonuclear leukocytes to monolayers of cultured endothelial cells.
J Immunol
136
3412-9
1986
Homo sapiens
Hallbach, J; Adams, G; Wirthensohn, G; Guder, WG
Quantification of kininogen in human renal medulla.
Biol Chem Hoppe Seyler
368
1151-5
1987
Homo sapiens, Sus scrofa
Hugli, TE; Gerard, C; Kawahara, M; Scheetz, ME; Barton, R; Briggs, S; Koppel, G; Russell, S
Isolation of three separate anaphylatoxins from complement-activated human serum.
Mol Cell Biochem
41
59-66
1981
Homo sapiens
Boscolo, P; Carmignani, M; Volpe, AR; Felaco, M; Del Rosso, G; Porcelli, G; Giuliano, G
Renal toxicity and arterial hypertension in rats chronically exposed to vanadate.
Occup Environ Med
51
500-3
1994
Rattus, Metazoa
Ura, N; Shimamoto, K; Nomura, N; Iwata, M; Aoyama, T; Takagawa, Y; Iimura, O
Significance of renal kininases in patients with primary aldosteronism.
Clin Exp Hypertens
17
1049-58
1995
Homo sapiens
Shimamoto, K; Ura, N; Nomura, N; Aoyama, T; Iwata, M; Takagawa, Y; Iimura, O
Significance of renal kininases in patients with Cushing's syndrome.
Clin Exp Hypertens
17
1173-82
1995
Homo sapiens
Chulak, C; Couture, R; Foucart, S
Modulatory effect of bradykinin on noradrenaline release in isolated atria from normal and B2 knockout transgenic mice.
Eur J Pharmacol
346
167-74
1998
Mus musculus
Uchikov, P; Terzieva, D; Shtereva, S; Sirakova, I
[Changes in some of the kallikrein-kinin system indices in patients with acute pancreatitis]
Khirurgiia (Sofiia)
55
5-9
1999
Homo sapiens
Todorov, AG; Andrade, D; Pesquero, JB; Araujo, Rde C; Bader, M; Stewart, J; Gera, L; MĆ¼ller-Esterl, W; Morandi, V; Goldenberg, RC; Neto, HC; Scharfstein, J
Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes.
FASEB J
17
73-5
2003
Cricetulus griseus, Homo sapiens, Mus sp., Rattus, Trypanosoma cruzi
GrabiÅska, KA; Ghosh, SK; Guan, Z; Cui, J; Raetz, CR; Robbins, PW; Samuelson, J
Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis.
Eukaryot Cell
7
1344-51
2008
Saccharomyces, Trichomonas
Zasada, M; Suski, M; Bokiniec, R; Szwarc-Duma, M; Borszewska-Kornacka, MK; Madej, J; Bujak-Gi?ycka, B; Madetko-Talowska, A; Revhaug, C; Baumbusch, LO; Saugstad, OD; Pietrzyk, JJ; Kwinta, P
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia.
Ital J Pediatr
45
112
2019
Homo sapiens
Islam, I; Bryant, J; May, K; Mohan, R; Yuan, S; Kent, L; Morser, J; Zhao, L; Vergona, R; White, K; Adler, M; Whitlow, M; Buckman, BO
3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa).
Bioorg Med Chem Lett
17
1349-54
2007
Homo sapiens, Sus scrofa, Oryctolagus cuniculus
Noguchi, K; Edo, N; Miyoshi, N; Isobe, A; Watanabe, A; Ito, Y; Morishima, Y; Yamaguchi, K
Fibrinolytic potential of DS-1040, a novel orally available inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa).
Thromb Res
168
96-101
2018
Homo sapiens
König, S; Steinebrey, N; Herrnberger, M; Escolano-Lozano, F; Schlereth, T; Rebhorn, C; Birklein, F
Reduced serum protease activity in Complex Regional Pain Syndrome: The impact of angiotensin-converting enzyme and carboxypeptidases.
J Pharm Biomed Anal
205
114307
2021
Homo sapiens
Ahmad, S; Ward, PE
Depressor action of bradykinin agonists relative to metabolism by angiotensin-converting enzyme, carboxypeptidase N, and aminopeptidase P.
Proc Soc Exp Biol Med
200
115-21
1992
Rattus
Ward, PE; Chow, A; Drapeau, G
Metabolism of bradykinin agonists and antagonists by plasma aminopeptidase P.
Biochem Pharmacol
42
721-7
1991
Rattus
Tan, F; Jackman, H; Skidgel, RA; Zsigmond, EK; Erdƶs, EG
Protamine inhibits plasma carboxypeptidase N, the inactivator of anaphylatoxins and kinins.
Anesthesiology
70
267-75
1989
Homo sapiens
Skidgel, RA; Johnson, AR; Erdƶs, EG
Hydrolysis of opioid hexapeptides by carboxypeptidase N. Presence of carboxypeptidase in cell membranes.
Biochem Pharmacol
33
3471-8
1984
Homo sapiens, Bos taurus
Gerhardt, W; KallĆ³s, P; Lundquist, A
Plasma carboxypeptidase activity and intolerance to acetylsalicylic acid unimpaired CP-N activity in ASA-intolerant individuals.
Int Arch Allergy Appl Immunol
69
206-9
1982
Homo sapiens
Blass, J; Detruit, H; Aime, L; Fiancette, JY; Gaillard, M; Verriest, C; Vicaigne, MB; Weiss, M
[Protaminase activity of plasma. III. Role of conversion enzyme (kininase II) in protaminase activity of plasma]
Pathol Biol (Paris)
36
1192-8
1988
Homo sapiens
Nishimura, T; Myles, T; Piliponsky, AM; Piliposky, AM; Kao, PN; Berry, GJ; Leung, LL
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.
Blood
109
1992-7
2007
Mus sp.
Ura, N; Shimamoto, K; Tanaka, S; Nishimiya, T; Mita, T; Nakagawa, M; Maeda, T; Yamaguchi, Y; Iimura, O
Urinary excretions of kininase I and kininase II activities in essential hypertension. A sensitive and simple method for its kinin-destroying capacity.
J Clin Hypertens
1
15-22
1985
Homo sapiens
Sommer, H; Schweisfurth, H; Schulz, M
Serum angiotensin-I-converting enzyme and carboxypeptidase N in Crohn's disease and ulcerative colitis.
Enzyme
35
181-8
1986
Homo sapiens
Ryan, JW; Berryer, P; Hart, MA; Ryan, US
Aggregate anaphylaxis and carboxypeptidase N.
Adv Exp Med Biol
198 Pt A
435-43
1986
Cavia, Metazoa
Skidgel, RA; Kawahara, MS; Hugli, TE
Functional significance of the subunits of carboxypeptidase N (kininase I).
Adv Exp Med Biol
198 Pt A
375-80
1986
Homo sapiens
Fisher, GH; Ryan, JW; Chung, A; Plumer, TH
Synthetic inhibitors of carboxypeptidase N.
Adv Exp Med Biol
198 Pt A
405-10
1986
Homo sapiens, Bos taurus
Mathews, KP; Curd, JG; Hugli, TE
Decreased synthesis of serum carboxypeptidase N (SCPN) in familial SCPN deficiency.
J Clin Immunol
6
87-91
1986
Homo sapiens
Kreutzer, DL; McCormick, JR; Despins, A; Moore, M; Rousou, JH; Dobbs, W; Engleman, RN
Characterization of the anaphylatoxin inactivator and chemotactic factor inactivator activities during cardiopulmonary bypass.
J Exp Pathol
1
183-7
1984
Homo sapiens
Huey, R; Bloor, CM; Kawahara, MS; Hugli, TE
Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue.
Am J Pathol
112
48-60
1983
Cavia, Cavia porcellus, Metazoa
Mathews, KP; Pan, PM; Gardner, NJ; Hugli, TE
Familial carboxypeptidase N deficiency.
Ann Intern Med
93
443-5
1980
Homo sapiens
Hendriks, D; Vingron, M; Vriend, G; Wang, W; Nalis, D; ScharpƩ, S
On the specificity of carboxypeptidase N, a comparative study.
Biol Chem Hoppe Seyler
374
843-9
1993
Bos taurus, Homo sapiens
Zaninotto, M; Altinier, S; Lachin, M; Plebani, M
Carboxypeptidase N and creatine kinase-MB isoforms in acute myocardial infarction.
Eur J Clin Chem Clin Biochem
35
291-5
1997
Homo sapiens
Sigler, C; Annis, K; Cooper, K; Haber, H; Van deCarr, S
Examination of baseline levels of carboxypeptidase N and complement components as potential predictors of angioedema associated with the use of an angiotensin-converting enzyme inhibitor.
Arch Dermatol
133
972-5
1997
Homo sapiens
Cao, H; Hegele, RA
DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency.
J Hum Genet
48
20-2
2003
Homo sapiens, insertion sequences
Tsukahara, Y; Itakura, A; Ohno, Y; Ando, H; Mizutani, S
Umbilical plasma kininase I activity in fetal hypoxia.
Horm Metab Res
35
583-7
2003
Homo sapiens
Darley, MM; Ramos, TN; Wetsel, RA; Barnum, SR
Deletion of carboxypeptidase N delays onset of experimental cerebral malaria.
Parasite Immunol
34
444-7
2012
Mus sp.
Ishida, H; Scicli, AG; Carretero, OA
Role of angiotensin converting enzyme and other peptidases in in vivo metabolism of kinins.
Hypertension
14
322-7
1989
Rattus
Schweisfurth, H; Schmidt, M; Brugger, E; Maiwald, L; Thiel, H
Alterations of serum carboxypeptidases N and angiotensin-I-converting enzyme in malignant diseases.
Clin Biochem
18
242-6
1985
Homo sapiens
Blais, C; Drapeau, G; Raymond, P; Lamontagne, D; Gervais, N; Venneman, I; Adam, A
Contribution of angiotensin-converting enzyme to the cardiac metabolism of bradykinin: an interspecies study.
Am J Physiol
273
H2263-71
1997
Homo sapiens, Canis lupus familiaris, Oryctolagus cuniculus, Rattus, Transformation
Sakakibara, T; Ura, N; Shimamoto, K; Ogata, H; Ando, T; Fukuyama, S; Yamaguchi, Y; Masuda, A; Mori, Y; Saito, S
Localization of neutral endopeptidase in the kidney determined by the stop-flow method.
Adv Exp Med Biol
247B
349-53
1989
Canis lupus familiaris
IgiÄ, R
Kallikrein and kininases in ocular tissues.
Exp Eye Res
41
117-20
1985
Sus scrofa
Iimura, O; Shimamoto, K; Ura, N; Mita, T; Tanaka, S; Nishimiya, T; Nakagawa, M; Yamaguchi, Y
Study on the renal kallikrein-kinin system in normal and low renin subgroups of essential hypertension.
J Hypertens Suppl
2
S297-9
1984
Homo sapiens
Perryman, MB; Knell, JD; Roberts, R
Carboxypeptidase-catalyzed hydrolysis of C-terminal lysine: mechanism for in vivo production of multiple forms of creatine kinase in plasma.
Clin Chem
30
662-4
1984
Homo sapiens, Canis lupus familiaris, Oryctolagus cuniculus
Heder, G; BĆøttger, A; Siems, WE; Rottmann, M; Kertscher, U
The enzymatic degradation of bradykinin in semen of various species.
Andrologia
26
295-301
0
Homo sapiens, Sus scrofa, Bos taurus
Ohkubo, K; Okuda, M; Kaliner, MA
Immunological localization of neuropeptide-degrading enzymes in the nasal mucosa.
Rhinology
32
130-3
1994
Homo sapiens, Areas, Lamina
Shinohara, T; Sakurada, C; Suzuki, T; Takeuchi, O; Campbell, W; Ikeda, S; Okada, N; Okada, H
Pro-carboxypeptidase R cleaves bradykinin following activation.
Int Arch Allergy Immunol
103
400-4
1994
Homo sapiens
Timofeev, ?V
[Basic carboxypeptidases of blood: significance for coagulology].
Biomed Khim
62
141-9
0
Homo sapiens
Kuefner, U; Lohrmann, U; Montejano, Y; Vitols, KS; Huennekens, FM
Chemotherapeutic potential of methotrexate peptides.
Adv Enzyme Regul
27
3-13
1988
Homo sapiens
Ijsselstijn, L; Papma, JM; Dekker, LJ; Calame, W; Stingl, C; Koudstaal, PJ; Prins, ND; Sillevis Smitt, PA; Luider, TM
Serum proteomics in amnestic mild cognitive impairment.
Proteomics
13
2526-33
2013
Homo sapiens
Lim, SK; Han, HJ; Kim, KY; Park, SH
Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.
J Cell Physiol
221
677-87
2009
Homo sapiens
Fresco, LD; Harper, DS; Keene, JD
Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions.
Mol Cell Biol
11
1578-89
1991
Human immunodeficiency virus 1
Dendorfer, A; Wagemann, M; Reissmann, S; Dominiak, P
Structural requirements for B2-agonists with improved degradation stability.
Immunopharmacology
45
199-205
1999
Rattus
Isono, K; Tamaoki, J; Chiyotani, A; Konno, K
[Effect of bradykinin on airway epithelial ion transport and its modulation by endogenous peptidases]
Kokyu To Junkan
41
581-5
1993
Canis lupus familiaris
Sakamoto, K; Sugimoto, K; Fujimura, A
Different inhibition of enalaprilat and imidaprilat on bradykinin metabolizing enzymes.
Life Sci
67
2159-65
2000
Mus musculus
Erdƶs, EG
Some old and some new ideas on kinin metabolism.
J Cardiovasc Pharmacol
15 Suppl 6
S20-4
1990
Homo sapiens
Bausback, HH; Ward, PE
Kallidin and bradykinin metabolism by isolated cerebral microvessels.
Biochem Pharmacol
37
2973-8
1988
Sus scrofa
Skidgel, RA; Erdƶs, EG
Kininase one-an'-a-half: the newest member of the kininase family.
Adv Exp Med Biol
198 Pt A
381-8
1986
Homo sapiens
Babiuk, C; Marceau, F; St-Pierre, S; Regoli, D
Kininases and vascular responses to kinins.
Eur J Pharmacol
78
167-74
1982
Oryctolagus cuniculus
Matsumura, Y; Maeda, H; Kato, H
Degradation pathway of kinins in tumor ascites and inhibition by kininase inhibitors: analysis by HPLC.
Agents Actions
29
172-80
1990
Homo sapiens
Sheikh, IA; Kaplan, AP
Studies of the digestion of bradykinin, lysyl bradykinin, and kinin-degradation products by carboxypeptidases A, B, and N.
Biochem Pharmacol
35
1957-63
1986
Homo sapiens
Paskhina, TS; Poliantseva, LR; Krinskaia, AV; Belolipetskaia, IuG; Nartikova, VF
[State of the kinin system and level of serum proteinase inhibitors in latent nephritis and the nephrotic syndrome of different etiology]
Vopr Med Khim
23
241-51
0
Homo sapiens
Frol'kis, RA; Gunina, LM
[Changes in the kallikrein-kinin system of the blood during development of experimental myocardial infarct]
Vopr Med Khim
24
747-53
0
Canis lupus familiaris
Paskhina, TS; Nartikova, VF; Dotsenko, VL; Maslova, TM; Morozova, NA
[State of the kinin system in burn shock and early toxemia]
Vopr Med Khim
22
696-707
0
Homo sapiens
Skidgel, RA; Tan, F
Structural features of two kininase I-type enzymes revealed by molecular cloning.
Agents Actions Suppl
38 ( Pt 1)
359-67
1992
Homo sapiens
Yanagisawa, K
[A study of the absorption of NPH insulin administered into subcutaneous tissue: in vitro study of the mechanism of insulin release from NPH insulin crystal]
Hokkaido Igaku Zasshi
67
81-8
1992
Homo sapiens
Lemke, HD; Heidland, A; Schaefer, RM
Hypersensitivity reactions during haemodialysis: role of complement fragments and ethylene oxide antibodies.
Nephrol Dial Transplant
5
264-9
1990
Homo sapiens, Dialysis
Salgado, HC; Carretero, OA; Scicli, AG; Murray, RD
Effect of DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid on the blood pressure response to vasoactive substances.
J Pharmacol Exp Ther
237
204-8
1986
Rattus
Bengtson, A; Millocco, I; Heideman, M; Berggren, H
Altered concentrations of terminal complement complexes, anaphylatoxins, and leukotrienes in the coronary sinus during cardiopulmonary bypass.
J Cardiothorac Anesth
3
305-10
1989
Homo sapiens
Ganu, VS; MĆ¼ller-Eberhard, HJ; Hugli, TE
Factor C3f is a spasmogenic fragment released from C3b by factors I and H: the heptadeca-peptide C3f was synthesized and characterized.
Mol Immunol
26
939-48
1989
Homo sapiens
Ura, N; Carretero, OA; Erdƶs, EG
Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo.
Kidney Int
32
507-13
1987
Rattus
Yamaguchi, Y; Shimamoto, K; Ura, N; Nishimiya, T; Nakagawa, M; Masuda, A; Ando, T; Iimura, O
Localization of renal kallikrein-kinin system components in the kidney.
Jpn J Med
25
9-12
1986
Canis lupus familiaris
Nakahashi, Y; Shimamoto, K; Ura, N; Tanaka, S; Nishitani, T; Ishida, H; Yokoyama, T; Ando, T; Iimura, O
Comprehensive studies on the renal kallikrein-kinin system in essential hypertension.
Adv Exp Med Biol
198 Pt B
351-7
1986
Homo sapiens
DĆ©carie, A; Drapeau, G; Closset, J; Couture, R; Adam, A
Development of digoxigenin-labeled peptide: application to chemiluminoenzyme immunoassay of bradykinin in inflamed tissues.
Peptides
15
511-8
1994
Oryctolagus cuniculus, Rattus
Gengin, MT; Vernigora, AN; Nikishin, NN; Makeeva, NV
[Effect of captopril and reserpine on the activity of certain neuropeptide metabolism enzymes]
Vopr Med Khim
41
37-9
0
Rattus
DĆ©carie, A; Raymond, P; Gervais, N; Couture, R; Adam, A
Serum interspecies differences in metabolic pathways of bradykinin and [des-Arg9]BK: influence of enalaprilat.
Am J Physiol
271
H1340-7
1996
Homo sapiens, Canis lupus familiaris, Oryctolagus cuniculus, Rattus, Transformation
Kuno, N; Mizutani, S; Ohno, Y; Goto, K; Itakura, A; Kondo, I; Kurauchi, O; Kikkawa, F; Tomoda, Y
Possible involvement of placental proteases in bradykinin (BK) degradation.
Reprod Fertil Dev
9
633-9
1997
Homo sapiens
Carmignani, M; Boscolo, P; Poma, A; Volpe, AR
Kininergic system and arterial hypertension following chronic exposure to inorganic lead.
Immunopharmacology
44
105-10
1999
Rattus
Younger, JG; Sasaki, N; Waite, MD; Murray, HN; Saleh, EF; Ravage, ZB; Hirschl, RB; Ward, PA; Till, GO; Ravage, ZA
Detrimental effects of complement activation in hemorrhagic shock.
J Appl Physiol
90
441-6
2001
Rattus, Metazoa
Petrushova, OP; Mikuliak, NI
[Proteolytic activity of fetoplacental complex in norm and pathology].
Biomed Khim
60
389-96
0
Homo sapiens
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