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Disease on EC 3.4.11.18 - methionyl aminopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Intermittent hypothermia is neuroprotective in an in vitro model of ischemic stroke.
Acute Lung Injury
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.
Adenocarcinoma
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers.
Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.
Adenoma
MAP-2 Expression in the Human Adenohypophysis and in Pituitary Adenomas. An Immunohistochemical Study.
Alzheimer Disease
5-HT1A agonist and dexamethasone reversal of para-chloroamphetamine induced loss of MAP-2 and synaptophysin immunoreactivity in adult rat brain.
In vitro polymerization of embryonic MAP-2c and fragments of the MAP-2 microtubule binding region into structures resembling paired helical filaments.
MAP-2 immunolabeling can distinguish diffuse from dense-core amyloid plaques in brains with Alzheimer's disease.
Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.
Self-assembly of the brain MAP-2 microtubule-binding region into polymeric structures resembling Alzheimer filaments.
Anemia, Sickle Cell
MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.
Arthritis
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458.
Arthritis, Experimental
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition.
Arthritis, Rheumatoid
A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis.
Astrocytoma
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Diagnostic utility of IDH1- and p53-mutation analysis in secondary gliosarcoma.
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.
Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas.
Autoimmune Diseases
Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity.
Babesiosis
Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis.
Brain Contusion
Widespread early dendritic injury associated with loss of cortical MAP-2 immunostaining in a focal ovine head impact model.
[Expression of microtubule associated protein-2 mRNA after cerebral contusion].
Brain Injuries
Combination of deferoxamine and erythropoietin: therapy for hypoxia-ischemia-induced brain injury in the neonatal rat?
The calpain proteolytic system in neonatal hypoxic-ischemia.
Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI mice.
[Neuroprotective effect and mechanisms of hypothermia in neonatal rat cerebral hypoxic-ischemic damages]
Brain Injuries, Diffuse
Temporal Profile of Microtubule Associated Protein (MAP-2) - A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma.
Brain Injuries, Traumatic
Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus.
Disruption of MAP-2 immunostaining in rat hippocampus after traumatic brain injury.
Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury.
Brain Ischemia
Cross-talk Between Calpain and Caspase-3 in Penumbra and Core During Focal Cerebral Ischemia-reperfusion.
[Study on trans-differentiation of adult human myoblasts into neural precursor cells and its implantation in rats]
Brain Neoplasms
Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus.
Carcinogenesis
A chemical and genetic approach to the mode of action of fumagillin.
Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.
MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.
Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target.
Carcinoid Tumor
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.
Carcinoma
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.
Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers.
Methionine aminopeptidases type I and type II are essential to control cell proliferation.
Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.
Carcinoma, Basal Cell
Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.
Carcinoma, Hepatocellular
Microtubule-associated protein-2 stimulates DNA synthesis catalyzed by the nuclear matrix.
Carcinoma, Merkel Cell
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Carcinoma, Neuroendocrine
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.
Carcinoma, Small Cell
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.
Carcinoma, Squamous Cell
Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.
Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers.
Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.
Cerebral Hemorrhage
Motor Skill Training Promotes Sensorimotor Recovery and Increases Microtubule-Associated Protein-2 (MAP-2) Immunoreactivity in the Motor Cortex after Intracerebral Hemorrhage in the Rat.
Cerebral Infarction
[Influence of hyperbaric oxygen treatment on neural plasticity in experimental rats]
[Study on the effect of cluster needling of scalp acupuncture on the plasticity protein MAP-2 in rats with focal cerebral infarction]
Cholangiocarcinoma
Blocking of methionine aminopeptidase-2 by TNP-470 induces apoptosis and increases chemosensitivity of cholangiocarcinoma.
Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target.
Possible involvement of cyclophilin a processing in fumagillin- induced suppression of cholangiocarcinoma cell proliferation.
TNP-470, A Methionine Aminopeptidase-2 Inhibitor, Inhibits Cell Proliferation, Migration and Invasion of Human Cholangiocarcinoma Cells In Vitro.
Cholera
Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons.
Phosphorylation of microtubule-associated protein-2 in GH3 cells. Regulation by cAMP and by calcium.
Choroid Plexus Neoplasms
Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region.
Choroidal Neovascularization
Evolving multidimensional pharmacological approaches to CNV therapy in AMD.
Ciliopathies
MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
Coinfection
Genetic variability of Alder yellows phytoplasma in Alnus glutinosa in its natural Spreewald habitat
Colonic Neoplasms
Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29.
Fumagillin inhibits colorectal cancer growth and metastasis in mice: in vivo and in vitro study of anti-angiogenesis.
MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.
Methionine aminopeptidase 2 and cancer.
Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumours.
NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells.
Colorectal Neoplasms
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
Methionine aminopeptidase 2 and cancer.
Coma
Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury.
Communicable Diseases
A simple, sensitive and reliable LC-MS/MS method for the determination of 7-bromo-5-chloroquinolin-8-ol (CLBQ14), a potent and selective inhibitor of methionine aminopeptidases: Application to pharmacokinetic studies.
In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases.
Pre-Clinical Pharmacokinetics, Tissue Distribution and Physicochemical Studies of CLBQ14, a Novel Methionine Aminopeptidase Inhibitor for the Treatment of Infectious Diseases.
Confusion
Microtubule-associated Protein-2 is a Sensitive Marker of Primary and Metastatic Neuroblastoma.
Diabetes Mellitus, Type 2
Efficacy and safety of methionine aminopeptidase 2 inhibition in type 2 diabetes: a randomised, placebo-controlled clinical trial.
The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial.
Diaschisis
Ultrastructure of diaschisis lesions following traumatic brain injury.
Encephalitis
Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis.
Encephalitis, Tick-Borne
Identification and biochemical characterisation of a novel methionine aminopeptidase from the taiga tick Ixodes persulcatus.
Endometriosis
Expression of microtubule associated protein 2 and synaptophysin in endometrium: high levels in deep infiltrating endometriosis lesions.
Ependymoma
Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region.
Epilepsy
Overexpression of MAP-2 via Formation of Microtubules Plays an Important Role in the Sprouting of Mossy Fibers in Epileptic Rats.
White matter neuronal heterotopia in temporal lobe epilepsy: a morphometric and immunohistochemical study.
Gastrointestinal Neoplasms
Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumours.
Glioblastoma
Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective.
Microtubule-associated protein 2 (MAP-2) is expressed in low and high grade diffuse astrocytomas.
Redox regulation of methionine aminopeptidase 2 activity.
Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2.
Glioma
Absence of neuron-associated microtubule proteins in the rat C-6 glioma cell line. A comparative immunoblot and immunohistochemical study.
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Identification and spatial arrangement of high molecular weight proteins (Mr 300 000-330 000) co-assembling with microtubules from a cultured cell line (rat glioma C6).
MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration.
Graves Disease
Identification Of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases By Deep Sequencing Of Linked Loci.
Hirschsprung Disease
Utility of Microtubule Associated Protein-2 (MAP-2) Immunohistochemistry for Identification of Ganglion Cells in Paraffin-Embedded Rectal Suction Biopsies.
Utility of Peripherin Versus MAP-2 and Calretinin in the Evaluation of Hirschsprung Disease.
Hypertension
Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Hypertension, Pulmonary
Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Hypothyroidism
Royal jelly increased map-2 expression in hippocampal neurons of hypothyroid rats: an immunohistochemical study.
Infarction, Middle Cerebral Artery
Calpain cleaves methionine aminopeptidase-2 in a rat model of ischemia/reperfusion.
Diacylglycerol kinase zeta is involved in the process of cerebral infarction.
Neuronal damage and plasticity identified by microtubule-associated protein 2, growth-associated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats.
NXY-059 maintains Akt activation and inhibits release of cytochrome C after focal cerebral ischemia.
Infections
In Vitro and In Vivo Characterization of Potent Antileishmanial Methionine Aminopeptidase-1 Inhibitors.
In Vitro Gene Silencing of the Fish Microsporidian Heterosporis saurida by RNA Interference.
Increased neurogenesis after experimental Streptococcus pneumoniae meningitis.
Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase.
Targeting essential genes of Nosema for the diagnosis of pebrine disease in silkworms.
Therapeutic targets for the treatment of microsporidiosis in humans.
Infertility
The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.
Insulinoma
Calcium-stimulated phosphorylation of MAP-2 in pancreatic betaTC3-cells is mediated by Ca2+/calmodulin-dependent kinase II.
Intellectual Disability
METAP1 mutation is a novel candidate for autosomal recessive intellectual disability.
Latent Tuberculosis
Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase.
Leiomyoma
Increased expression of neurogenic factors in uterine fibroids.
Leishmaniasis
Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.
Leishmaniasis, Visceral
A novel recombinant Leishmania donovani p45, a partial coding region of methionine aminopeptidase, generates protective immunity by inducing a Th1 stimulatory response against experimental visceral leishmaniasis.
Leukemia
Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
Lung Diseases
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.
Lung Neoplasms
Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers.
Lupus Vasculitis, Central Nervous System
Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus.
Lyme Disease
Identification and biochemical characterisation of a novel methionine aminopeptidase from the taiga tick Ixodes persulcatus.
Lymphoma
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.
Expression of microtubule-associated proteins, MAP-1 and MAP-2, in human neuroblastomas and differential diagnosis of immature neuroblasts.
High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts.
Lymphoma, B-Cell
High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts.
Lymphoma, Non-Hodgkin
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
Macular Degeneration
Evolving multidimensional pharmacological approaches to CNV therapy in AMD.
Malaria
Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis.
Antiparasitic activities of novel, orally available fumagillin analogs.
Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.
Functional characterization of both MAP kinases of the human malaria parasite Plasmodium falciparum by reverse genetics.
PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum.
Medulloblastoma
Apoptosis, neuronal maturation, and neurotrophin expression within medulloblastoma nodules.
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
SPARC Stimulates Neuronal Differentiation of Medulloblastoma Cells via the Notch1/STAT3 Pathway.
Melanoma
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Differential expression of microtubule-associated protein 2 in melanocytic skin lesions.
Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma.
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
Mesothelioma
High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts.
Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
Microsporidiosis
Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis.
Molecular characterization of Nosema bombycis methionine aminopeptidase 2 (MetAP2) gene and evaluation of anti-microsporidian activity of Fumagilin-B in silkworm Bombyx mori.
System for Expression of Microsporidian Methionine Amino Peptidase Type 2 (MetAP2) in the Yeast Saccharomyces cerevisiae.
Therapeutic targets for the treatment of microsporidiosis in humans.
Neoplasm Metastasis
CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.
Differential expression of microtubule-associated protein 2 in melanocytic skin lesions.
Hypoxia-Induced LIN28A mRNA Promotes the Metastasis of Colon Cancer in a Protein-Coding-Independent Manner.
Neoplasms
1,3,4-Oxadiazoles: An emerging scaffold to target growth factors, enzymes and kinases as anticancer agents.
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.
5-demethylovalicin, as a methionine aminopeptidase-2 inhibitor produced by Chrysosporium.
A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
Cerebellar Liponeurocytoma, an Unusual Tumor of the Central Nervous System--Ultrastructural Examination.
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.
Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor.
Diagnostic utility of IDH1- and p53-mutation analysis in secondary gliosarcoma.
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Diagnostic value of microtubule-associated protein-2 in Merkel cell carcinoma.
Differential expression of microtubule-associated protein 2 in melanocytic skin lesions.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors.
Discovery, identification, and characterization of candidate pharmacodynamic markers of methionine aminopeptidase-2 inhibition.
Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation.
Expression of microtubule-associated proteins, MAP-1 and MAP-2, in human neuroblastomas and differential diagnosis of immature neuroblasts.
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis.
High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas.
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies.
Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region.
Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation.
In silico identification of microRNAs predicted to regulate N-myristoyltransferase and Methionine Aminopeptidase 2 functions in cancer and infectious diseases.
In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification.
Increased expression of neurogenic factors in uterine fibroids.
Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration.
MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer.
Metabolites of PPI-2458, a Selective, Irreversible Inhibitor of Methionine Aminopeptidase-2: Structure Determination and In Vivo Activity.
MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.
Methionine aminopeptidase 2 and cancer.
Methionine Aminopeptidase 2 as a Potential Therapeutic Target for Human Non-Small-Cell Lung Cancers.
Methionine aminopeptidase 2 over-expressed in cholangiocarcinoma: potential for drug target.
Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition.
Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity.
Methionine aminopeptidases and angiogenesis.
Methionine Aminopeptidases as Potential Targets for Treatment of Gastrointestinal Cancers and other Tumours.
Microtubule-associated Protein-2 is a Sensitive Marker of Primary and Metastatic Neuroblastoma.
Microtubule-associated protein-2: a new sensitive and specific marker for pulmonary carcinoid tumor and small cell carcinoma.
Novel inhibitors targeted to methionine aminopeptidase 2 (MetAP2) strongly inhibit the growth of cancers in xenografted nude model.
Optimizing the dosing schedule of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol] enhances its antitumor and antiangiogenic efficacies.
Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.
Possible involvement of cyclophilin a processing in fumagillin- induced suppression of cholangiocarcinoma cell proliferation.
Redox regulation of methionine aminopeptidase 2 activity.
Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.
Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2.
Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity.
The clinicopathological features of liponeurocytoma.
The Development of MetAP-2 Inhibitors in Cancer Treatment.
The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis.
TNP-470, A Methionine Aminopeptidase-2 Inhibitor, Inhibits Cell Proliferation, Migration and Invasion of Human Cholangiocarcinoma Cells In Vitro.
Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2.
Neoplasms, Neuroepithelial
MAP-2 immunoexpression in gliomatosis cerebri.
Nervous System Diseases
Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus.
Neuritis
[Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells]
Neuroblastoma
Aminohexanoic hydroxamate is a potent inducer of the differentiation of mouse neuroblastoma cells.
Anti-brain cancer activity of chloroform and hexane extracts of Tinospora cordifolia Miers: an in vitro perspective.
Differential distribution of microtubule-associated proteins MAP-1 and MAP-2 in neurons of rat brain and association of MAP-1 with microtubules of neuroblastoma cells (clone N2A).
Expression of microtubule-associated proteins, MAP-1 and MAP-2, in human neuroblastomas and differential diagnosis of immature neuroblasts.
Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2.
Localization of specific epitopes on human microtubule-associated protein 2.
Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models.
Microtubule-associated Protein-2 is a Sensitive Marker of Primary and Metastatic Neuroblastoma.
Prospects for therapeutic inhibition of neuroblastoma angiogenesis.
Sellar neuroblastoma mimicking a pituitary tumour: case report and review of the literature.
Tinospora cordifolia Induces Differentiation and Senescence Pathways in Neuroblastoma Cells.
Neurocytoma
Diagnostic value of microtubule-associated protein-2 (MAP-2) for neuroendocrine neoplasms.
Neurodegenerative Diseases
Survey for CAG repeat polymorphisms in the human MAP-2 gene.
Neurofibromatoses
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Nevus, Pigmented
Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma.
Obesity
Approaches for the Development of Drugs for Treatment of Obesity and Metabolic Syndrome.
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1.
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 2.
Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial.
Efficacy and safety of methionine aminopeptidase 2 inhibition in type 2 diabetes: a randomised, placebo-controlled clinical trial.
Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity.
MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.
Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity.
Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity.
Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity.
Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 inhibitors.
Ovarian Cysts
Increased expression of neurogenic factors in uterine fibroids.
Overweight
The methionine aminopeptidase 2 inhibitor ZGN-1061 improves glucose control and weight in overweight and obese individuals with type 2 diabetes: A randomized, placebo-controlled trial.
[Significance of mean arterial blood pressure in the 2d trimester and the roll-over test for gestosis screening in normal, overweight and underweight primigravid patients]
Persistent Vegetative State
Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury.
Pituitary Neoplasms
MAP-2 Expression in the Human Adenohypophysis and in Pituitary Adenomas. An Immunohistochemical Study.
Pneumonia
Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases.
Prader-Willi Syndrome
Effects of MetAP2 inhibition on hyperphagia and body weight in Prader-Willi syndrome: A randomized, double-blind, placebo-controlled trial.
Preclinical Efficacy and Safety of the Novel Antidiabetic, Antiobesity MetAP2 Inhibitor ZGN-1061.
Pre-Eclampsia
Elevated midtrimester mean arterial blood pressure in women with severe preeclampsia.
Prediabetic State
MetAP2 Inhibitor Treatment of High-Fat and -Fructose Fed Dogs: Impact on the Response to Oral Glucose Ingestion and a Hyperinsulinemic Hyperglycemic Clamp.
Prostatic Neoplasms
In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification.
Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II).
Pulmonary Arterial Hypertension
Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Pulmonary Fibrosis
Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis.
Retinoblastoma
Immunohistochemical analysis of retinoblastoma cell phenotype using neuronal and glial cell markers.
Rett Syndrome
Dendritic cytoskeletal protein expression in mental retardation: an immunohistochemical study of the neocortex in Rett syndrome.
Rhabdomyosarcoma
Expression of microtubule-associated proteins, MAP-1 and MAP-2, in human neuroblastomas and differential diagnosis of immature neuroblasts.
Sarcoma
Microtubule-associated Protein-2 is a Sensitive Marker of Primary and Metastatic Neuroblastoma.
Sarcoma, Ewing
Expression of microtubule-associated proteins, MAP-1 and MAP-2, in human neuroblastomas and differential diagnosis of immature neuroblasts.
Seizures
Effect of connexin 36 blockers on the neuronal cytoskeleton and synaptic plasticity in kainic acid-kindled rats.
Starvation
An alternative methionine aminopeptidase, MAP-A, is required for nitrogen starvation and high-light acclimation in the cyanobacterium Synechocystis sp. PCC 6803.
[The influence of protein starvation on hydrolytic and transport characteristics of the rat small intestine in chronic experiments]
Stroke
Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus.
Cortical neurogenesis in adult rats after reversible photothrombotic stroke.
Cortical neurogenesis in adult rats after transient middle cerebral artery occlusion.
Synovitis
Involution of collagen-induced arthritis with an angiogenesis inhibitor, PPI-2458.
Tetanus
Neuronal development and migration in explant cultures of the adult canary forebrain.
Thyroiditis
Identification Of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases By Deep Sequencing Of Linked Loci.
Tuberculosis
Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity.
Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis.
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.
Computational validation of 3-ammonio-3-(4-oxido- 1H-imidazol-1-ium-5-yl) propane-1, 1-bis (olate) as a potent anti-tubercular drug against mt-MetAP.
Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme.
Expression and characterization of Mycobacterium tuberculosis methionine aminopeptidase type 1a.
Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosome.
MapB Protein is the Essential Methionine Aminopeptidase in Mycobacterium tuberculosis.
Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targets.
Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase.
Structural analysis of inhibition of Mycobacterium tuberculosis methionine aminopeptidase by bengamide derivatives.
The unique functional role of the C-HS hydrogen bond in the substrate specificity and enzyme catalysis of type 1 methionine aminopeptidase.
Uterine Cervical Neoplasms
Molecular analysis of cellular loci disrupted by papillomavirus 16 integration in cervical cancer: frequent viral integration in topologically destabilized and transcriptionally active chromosomal regions.
Vitamin E Deficiency
Vitamin E deficiency and aging effect on expression levels of GAP-43 and MAP-2 in selected areas of the brain.