Disease on EC 3.2.2.21 - DNA-3-methyladenine glycosylase II
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Acquired Immunodeficiency Syndrome
Modeling the chemical step utilized by human alkyladenine DNA glycosylase: a concerted mechanism AIDS in selectively excising damaged purines.
Adenocarcinoma
Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.
Adenocarcinoma
Reduced expression of the DNA glycosylase gene MUTYH is associated with an increased number of somatic mutations via a reduction in the DNA repair capacity in prostate adenocarcinoma.
Adenocarcinoma of Lung
[Effects of hydroquinone on expression of human 8-oxo-guanine DNA glycosylase mRNA in human A549 lung adenocarcinoma cell strains]
Adenoma
A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus.
Adenoma
Association of a New Germline Variant in the MUTYH DNA Glycosylase Gene with Colorectal Adenoma Transformation into Malignancy
Adenoma
Functional Evaluation of Nine Missense-Type Variants of the Human DNA Glycosylase Enzyme MUTYH in the Japanese Population.
Adenoma
Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma.
Adenoma
Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.
Adenoma
Response to the Letter titled, "Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma," written by J. P. Cheadle.
Adenomatous Polyposis Coli
A functional analysis of the DNA glycosylase activity of mouse MUTYH protein excising 2-hydroxyadenine opposite guanine in DNA.
Adenomatous Polyposis Coli
Clinicopathological and molecular characteristics of abdominal desmoid tumors in the Chinese population: A single-center report of 15 cases.
Adenomatous Polyposis Coli
Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study.
Adenomatous Polyposis Coli
Synonymous mutation adenomatous polyposis coli?486s affects exon splicing and may predispose patients to adenomatous polyposis coli/mutY DNA glycosylase mutation?negative familial adenomatous polyposis.
Atherosclerosis
Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis.
Atherosclerosis
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development.
Atherosclerosis
High glucose induced endothelial cell reactive oxygen species via OGG1/PKC/NADPH oxidase pathway.
Atherosclerosis
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice.
Brain Infarction
Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion.
Brain Ischemia
Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia.
Breast Neoplasms
A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase.
Breast Neoplasms
Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in breast cancer.
Breast Neoplasms
Estradiol receptor potentiates, in vitro, the activity of 5-methylcytosine DNA glycosylase.
Breast Neoplasms
Lack of association between the hOGG1 Ser326Cys polymorphism and breast cancer risk: evidence from 11 case-control studies.
Breast Neoplasms
Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.
Breast Neoplasms
Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.
Breast Neoplasms
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Breast Neoplasms
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.
Carcinogenesis
DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis.
Carcinogenesis
Generation of a strong mutator phenotype in yeast by imbalanced base excision repair.
Carcinogenesis
Increased formation and persistence of 1,N(6)-ethenoadenine in DNA is not associated with higher susceptibility to carcinogenesis in alkylpurine-DNA-N-glycosylase knockout mice treated with vinyl carbamate.
Carcinogenesis
Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.
Carcinogenesis
S-Allylcysteine inhibits tumour progression and the epithelial-mesenchymal transition in a mouse xenograft model of oral cancer.
Carcinoma
A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus.
Carcinoma
An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy.
Carcinoma
Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine.
Carcinoma
Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells.
Carcinoma
Inherited defects in the DNA glycosylase MYH cause multiple colorectal adenoma and carcinoma.
Carcinoma
Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma.
Carcinoma
Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.
Carcinoma, Hepatocellular
Constitutive expression and inducibility of O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation.
Carcinoma, Hepatocellular
Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
Carcinoma, Hepatocellular
Prognostic impact of 8-hydroxy-deoxyguanosine and its repair enzyme 8-hydroxy-deoxyguanosine DNA glycosylase in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
[Inhibitory Effect of Human Mitochondria-targeted MPG Recombinant on Proliferation of Human Non-small Cell Lung Cancer Multidrug-resistant Cell Line A549/DDP.]
Cardiovascular Diseases
Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases.
Cockayne Syndrome
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity.
Cockayne Syndrome
Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase.
Colonic Neoplasms
DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase.
Colonic Neoplasms
Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study.
Colonic Neoplasms
The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.
Colorectal Neoplasms
DNA repair of oxidative DNA damage in human carcinogenesis: potential application for cancer risk assessment and prevention.
Colorectal Neoplasms
Exposing the MYtH about base excision repair and human inherited disease.
Colorectal Neoplasms
Further delineation of the NTHL1 associated syndrome: A report from the French Oncogenetic Consortium.
Colorectal Neoplasms
Gene susceptibility to oxidative damage: From single nucleotide polymorphisms to function.
Colorectal Neoplasms
Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis.
Colorectal Neoplasms
Reprint of: Gene susceptibility to oxidative damage: From single nucleotide polymorphisms to function.
Diabetes Mellitus
Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus.
Diabetes Mellitus, Type 1
The effect of 3-methyladenine DNA glycosylase-mediated DNA repair on the induction of toxicity and diabetes by the beta-cell toxicant streptozotocin.
Diabetes Mellitus, Type 2
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
Diabetes Mellitus, Type 2
Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus.
dna-3-methyladenine glycosylase ii deficiency
Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.
dna-3-methyladenine glycosylase ii deficiency
Cloning of Escherichia coli genes encoding 3-methyladenine DNA glycosylases I and II.
dna-3-methyladenine glycosylase ii deficiency
DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
Esophageal Neoplasms
The OGG1 Ser326Cys Polymorphism and the Risk of Esophageal Cancer: A Meta-Analysis.
Esophageal Squamous Cell Carcinoma
An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy.
Genetic Diseases, Inborn
Defective repair capacity of variant proteins of the DNA glycosylase NTHL1 for 5-hydroxyuracil, an oxidation product of cytosine.
Glioblastoma
Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.
Glioblastoma
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Glioblastoma
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells.
Glioblastoma
Mitigating temozolomide resistance in glioblastoma via DNA damage-repair inhibition.
Glioma
Aberrant expression of N-methylpurine-DNA glycosylase influences patient survival in malignant gliomas.
Glioma
Involvement of N-methylpurine DNA glycosylase in resistance to temozolomide in patient-derived glioma cells.
Glioma
N-methylpurine DNA glycosylase and DNA polymerase {beta} modulate BER inhibitor potentiation of glioma cells to temozolomide.
Hepatitis B
Protein x of hepatitis B virus: origin and structure similarity with the central domain of DNA glycosylase.
HIV Infections
Impaired base excision repair and accumulation of oxidative base lesions in CD4+ T cells of HIV-infected patients.
Hyperinsulinism
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
Hypersensitivity
The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks.
Infections
Deficiency in OGG1 Protects against Inflammation and Mutagenic Effects Associated with H. pylori Infection in Mouse.
Infections
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells.
Infections
The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells.
Insulin Resistance
High glucose induced endothelial cell reactive oxygen species via OGG1/PKC/NADPH oxidase pathway.
Ischemic Stroke
NEIL1 stimulates neurogenesis and suppresses neuroinflammation after stress.
Lung Neoplasms
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
Lung Neoplasms
N-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.
Lung Neoplasms
Novel genetic polymorphisms in DNA repair genes: O(6)-methylguanine-DNA methyltransferase (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland.
Lung Neoplasms
[Inhibitory Effect of Human Mitochondria-targeted MPG Recombinant on Proliferation of Human Non-small Cell Lung Cancer Multidrug-resistant Cell Line A549/DDP.]
Lymphoma, B-Cell
Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice.
Melanoma
Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance.
Melanoma
Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress.
Metabolic Diseases
Oxidative DNA damage in disease-Insights gained from base excision repair glycosylase-deficient mouse models.
Metabolic Syndrome
The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase.
Multiple Myeloma
DNA Hypermethylation and Partial Gene Silencing of Human Thymine- DNA Glycosylase in Multiple Myeloma Cell Lines.
Neoplasms
A novel patient-derived cell line of adrenocortical carcinoma shows a pathogenic role of germline MUTYH mutation and high tumour mutational burden.
Neoplasms
Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.
Neoplasms
Adoptive immunotherapy for superficial bladder cancer with autologous macrophage activated killer cells.
Neoplasms
Altered expression of the DNA repair protein, N-methylpurine-DNA glycosylase (MPG) in human gonads.
Neoplasms
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.
Neoplasms
Association of a New Germline Variant in the MUTYH DNA Glycosylase Gene with Colorectal Adenoma Transformation into Malignancy
Neoplasms
Clinicopathological and molecular characteristics of abdominal desmoid tumors in the Chinese population: A single-center report of 15 cases.
Neoplasms
Concordant loss of heterozygosity of DNA repair gene, hOGG1, in melanoma in situ and atypical melanocytic hyperplasia.
Neoplasms
Construction of a self-directed replication system for label-free and real-time sensing of repair glycosylases with zero background.
Neoplasms
Controllable Autocatalytic Cleavage-Mediated Fluorescence Recovery for Homogeneous Sensing of Alkyladenine DNA Glycosylase from Human Cancer Cells.
Neoplasms
Controlled exposure to diesel exhaust and traffic noise--Effects on oxidative stress and activation in mononuclear blood cells.
Neoplasms
Diagnostic correlation between the expression of the DNA repair enzyme N-methylpurine DNA glycosylase and esophageal adenocarcinoma onset: a retrospective pilot study.
Neoplasms
DNA methylation reprogramming of human cancer cells by expression of a plant 5-methylcytosine DNA glycosylase.
Neoplasms
DNA repair genes polymorphisms and genetic susceptibility to Philadelphia-negative myeloproliferative neoplasms in a Portuguese population: The role of base excision repair genes polymorphisms.
Neoplasms
Dramatic reduction of sequence artefacts from DNA isolated from formalin-fixed cancer biopsies by treatment with uracil- DNA glycosylase.
Neoplasms
Expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in astrocytic tumors.
Neoplasms
Further delineation of the NTHL1 associated syndrome: A report from the French Oncogenetic Consortium.
Neoplasms
Gene amplification and expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in HPV-infected cervical neoplasias.
Neoplasms
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Neoplasms
Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.
Neoplasms
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Neoplasms
Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia.
Neoplasms
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Neoplasms
Human methyl purine DNA glycosylase and DNA polymerase beta expression collectively predict sensitivity to temozolomide.
Neoplasms
Integrated analysis revealing genome-wide chromosomal copy number variation in supraglottic laryngeal squamous cell carcinoma.
Neoplasms
Multiple genetic alterations involved in the tumorigenesis of human cholangiocarcinoma: a molecular genetic and clinicopathological study.
Neoplasms
MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis.
Neoplasms
Oxidative DNA damage in disease-Insights gained from base excision repair glycosylase-deficient mouse models.
Neoplasms
Phosphorylation of human oxoguanine DNA glycosylase (alpha-OGG1) modulates its function.
Neoplasms
Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level.
Neoplasms
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications.
Neoplasms
The hOGG1 Ser326Cys polymorphism contributes to cancer susceptibility: evidence from 83 case-control studies.
Neoplasms
The hOGG1 Ser326Cys polymorphism contributes to digestive system cancer susceptibility: evidence from 48 case-control studies.
Neoplasms
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Neoplasms
Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization.
Neoplasms
[Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells]
Neoplasms, Germ Cell and Embryonal
Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.
Neoplastic Syndromes, Hereditary
Further delineation of the NTHL1 associated syndrome: A report from the French Oncogenetic Consortium.
Neurodegenerative Diseases
Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei.
Neurodegenerative Diseases
Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.
Nijmegen Breakage Syndrome
ROS-dependent DNA damage and repair during germination of NaCl primed seeds.
Obesity
High glucose induced endothelial cell reactive oxygen species via OGG1/PKC/NADPH oxidase pathway.
Obesity
Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
Osteosarcoma
[Effect of adenoviral N-methylpurine DNA glycosylase overexpression on chemosensitivity of human osteosarcoma cells]
Ovarian Neoplasms
A common SNP in the uracil-DNA glycosylase gene UNG decreases ovarian cancer risk in BRCA2 mutation carriers.
Ovarian Neoplasms
Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.
Prion Diseases
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Radiation Pneumonitis
An NEIL1 single nucleotide polymorphism (rs4462560) predicts the risk of radiation-induced toxicities in esophageal cancer patients treated with definitive radiotherapy.
Retinal Degeneration
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.
Stomach Neoplasms
Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system.
Thymoma
Tissue-specific expression and activation of N-methylpurine-DNA glycosylase in thymic carcinomas of transgenic mice expressing the SV40 large T-antigen gene.
Tuberculosis
A novel bicistronic vector for overexpressing Mycobacterium tuberculosis proteins in Escherichia coli.
Tuberculosis
Characterization of a conserved interaction between DNA glycosylase and ParA in Mycobacterium smegmatis and M. tuberculosis.
Urinary Bladder Neoplasms
Adoptive immunotherapy for superficial bladder cancer with autologous macrophage activated killer cells.
Uterine Cervical Neoplasms
Gene amplification and expression of the DNA repair enzyme, N-methylpurine-DNA glycosylase (MPG) in HPV-infected cervical neoplasias.
Werner Syndrome
Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases.
Werner Syndrome
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1.
Xeroderma Pigmentosum
Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death.
Xeroderma Pigmentosum
The human oxidative DNA glycosylase NEIL1 excises psoralen-induced interstrand DNA cross-links in a three-stranded DNA structure.
Xeroderma Pigmentosum
Transient and stable complementation of ultraviolet repair in xeroderma pigmentosum cells by the denV gene of bacteriophage T4.
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