Reference on EC 3.1.4.41 - sphingomyelin phosphodiesterase D and Organism(s) Loxosceles laeta and UniProt Accession Q8I914
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Van Meeteren, L.A.; Frederiks, F.; Giepmans, B.N.G.; Pedrosa, M.F.F.; Billington, S.J.; Jost, B.H.; Tambourgi, D.V.; Moolenaar, W.H.
Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine
J. Biol. Chem.
279
10833-10836
2004
Corynebacterium pseudotuberculosis, Loxosceles laeta
Murakami, M.T.; Fernandes-Pedrosa, M.F.; de Andrade, S.A.; Gabdoulkhakov, A.; Betzel, C.; Tambourgi, D.V.; Arni, R.K.
Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases
Biochem. Biophys. Res. Commun.
342
323-329
2006
Loxosceles laeta (Q8I914)
Murakami, M.T.; Fernandes-Pedrosa, M.F.; Tambourgi, D.V.; Arni, R.K.
Structural basis for metal ion coordination and the catalytic mechanism of sphingomyelinases D
J. Biol. Chem.
280
13658-13664
2005
Loxosceles laeta
Olvera, A.; Ramos-Cerrillo, B.; Estevez, J.; Clement, H.; de Roodt, A.; Paniagua-Solis, J.; Vazquez, H.; Zavaleta, A.; Arruz, M.S.; Stock, R.P.; Alagon, A.
North and South American Loxosceles spiders: development of a polyvalent antivenom with recombinant sphingomyelinases D as antigens
Toxicon
48
64-74
2006
Loxosceles boneti (Q5YD76), Loxosceles boneti, Loxosceles laeta (Q1KY80), Loxosceles laeta, Loxosceles reclusa (Q5YD75), Loxosceles reclusa
de Almeida, D.M.; Fernandes-Pedrosa, M.d.e..F.; de Andrade, R.M.; Marcelino, J.R.; Gondo-Higashi, H.; de Azevedo, I.d.e..L.; Ho, P.L.; van den Berg, C.; Tambourgi, D.V.
A new anti-loxoscelic serum produced against recombinant sphingomyelinase D: results of preclinical trials
Am. J. Trop. Med. Hyg.
79
463-470
2008
Loxosceles gaucho, Loxosceles intermedia (P0CE81), Loxosceles intermedia (P0CE83), Loxosceles intermedia, Loxosceles laeta (Q8I914), Loxosceles laeta
Binford, G.J.; Bodner, M.R.; Cordes, M.H.; Baldwin, K.L.; Rynerson, M.R.; Burns, S.N.; Zobel-Thropp, P.A.
Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms
Mol. Biol. Evol.
26
547-566
2009
Ixodes scapularis (Q202J4), Loxosceles amazonica, Loxosceles apachea, Loxosceles arizonica (Q7Z1Y7), Loxosceles deserta, Loxosceles hirsuta, Loxosceles intermedia (P0CE81), Loxosceles intermedia (P0CE83), Loxosceles laeta (Q1KY79), Loxosceles laeta (Q1KY80), Loxosceles reclusa (P0CE78), Loxosceles rufescens, Loxosceles sabina, Loxosceles spadicea, Loxosceles speluncarum, Loxosceles spinulosa, Loxosceles vonwredei, no activity in Drymusa capensis, no activity in Drymusa dinora, no activity in Drymusa serrana, no activity in Sicarius peruensis, no activity in Sicarius rugosus, no activity in Sicarius rupestris, no activity in Sicarius terrosus, Sicarius albospinosus, Sicarius damarensis, Sicarius dolichocephalus, Sicarius hahni, Sicarius patagonicus
de Santi Ferrara, G.I.; Fernandes-Pedrosa, M.D.; Junqueira-de-Azevedo, I.D.; Goncalves-de-Andrade, R.M.; Portaro, F.C.; Manzoni-de-Almeida, D.; Murakami, M.T.; Arni, R.K.; van den Berg, C.W.; Ho, P.L.; Tambourgi, D.V.
SMase II, a new sphingomyelinase D from Loxosceles laeta venom gland: Molecular cloning, expression, function and structural analysis
Toxicon
53
743-753
2009
Loxosceles laeta (Q8I912), Loxosceles laeta (Q8I914), Loxosceles laeta
Catalan, A.; Cortes, W.; Sagua, H.; Gonzalez, J.; Araya, J.E.
Two new phospholipase D isoforms of Loxosceles laeta: Cloning, heterologous expression, functional characterization, and potential biotechnological application
J. Biochem. Mol. Toxicol.
25
393-403
2011
Loxosceles laeta
Gomes, M.T.; Guimaraes, G.; Frezard, F.; Kalapothakis, E.; Minozzo, J.C.; Chaim, O.M.; Veiga, S.S.; Oliveira, S.C.; Chavez-Olortegui, C.
Determination of sphingomyelinase-D activity of Loxosceles venoms in sphingomyelin/cholesterol liposomes containing horseradish peroxidase
Toxicon
57
574-579
2011
Loxosceles gaucho, Loxosceles intermedia, Loxosceles laeta, Loxosceles similis, no activity in Bothrops jararaca, no activity in Crotalus durissus, no activity in Lachesis muta, no activity in Micrurus frontalis, no activity in Phoneutria nigriventer, no activity in Tityus serrulatus
Stock, R.P.; Brewer, J.; Wagner, K.; Ramos-Cerrillo, B.; Duelund, L.; Jernsh?j, K.D.; Olsen, L.F.; Bagatolli, L.A.
Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate
PLoS ONE
7
e36003
2012
Loxosceles laeta
Lajoie, D.M.; Zobel-Thropp, P.A.; Kumirov, V.K.; Bandarian, V.; Binford, G.J.; Cordes, M.H.
Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates
PLoS ONE
8
e72372
2013
Loxosceles arizonica (Q4ZFU2), Loxosceles laeta, Loxosceles reclusa
Catalan, A.; Cortes, W.; Munoz, C.; Araya, J.E.
Tryptophan and aspartic acid residues present in the glycerophosphoryl diester phosphodiesterase (GDPD) domain of the Loxosceles laeta phospholipase D are essential for substrate recognition
Toxicon
81
43-47
2014
Loxosceles laeta
Pedroso, A.; Matioli, S.R.; Murakami, M.T.; Pidde-Queiroz, G.; Tambourgi, D.V.
Adaptive evolution in the toxicity of a spiders venom enzymes
BMC Evol. Biol.
15
290
2015
Arcanobacterium haemolyticum, Corynebacterium pseudotuberculosis, Ixodes scapularis, Loxosceles adelaida, Loxosceles aff. spinulosa GJB-2008, Loxosceles amazonica, Loxosceles apachea, Loxosceles arizonica, Loxosceles boneti, Loxosceles cf. spinulosa GJB-2008, Loxosceles deserta, Loxosceles gaucho, Loxosceles hirsuta, Loxosceles intermedia, Loxosceles laeta, Loxosceles reclusa, Loxosceles rufescens, Loxosceles sabina, Loxosceles similis, Loxosceles sp. 4 GJB-2008, Loxosceles spadicea, Loxosceles spinulosa, Loxosceles variegata, Rhipicephalus pulchellus, Sicarius albospinosus, Sicarius damarensis, Sicarius patagonicus, Sicarius peruensis, Sicarius terrosus
Lopes, P.H.; Murakami, M.T.; Portaro, F.C.V.; Mesquita Pasqualoto, K.F.; van den Berg, C.; Tambourgi, D.V.
Targeting Loxosceles spider sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism
J. Enzyme Inhib. Med. Chem.
34
310-321
2019
Loxosceles laeta
Correa, M.A.; Okamoto, C.K.; Goncalves-de-Andrade, R.M.; van den Berg, C.W.; Tambourgi, D.V.
Sphingomyelinase D from Loxosceles laeta venom induces the expression of MMP7 in human keratinocytes contribution to dermonecrosis
PLoS ONE
11
e0153090
2016
Loxosceles laeta
Rivera, I.G.; Ordonez, M.; Presa, N.; Gomez-Larrauri, A.; Simon, J.; Trueba, M.; Gomez-Munoz, A.
Sphingomyelinase D/ceramide 1-phosphate in cell survival and inflammation
Toxins
7
1457-1466
2015
Arcanobacterium haemolyticum, Corynebacterium pseudotuberculosis, Corynebacterium ulcerans, Loxosceles arizonica, Loxosceles gaucho, Loxosceles intermedia, Loxosceles laeta, Loxosceles reclusa, Loxosceles rufescens, Photobacterium damselae subsp. damselae
