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EC Tree
The taxonomic range for the selected organisms is: Mus musculus The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
acid phosphatase, tartrate-resistant acid phosphatase, prostatic acid phosphatase, tracp, acpase, uteroferrin, tracp 5b, phosphatidic acid phosphatase, tracp5b, pp2a phosphatase,
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acid monophosphatase
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acid nucleoside diphosphate phosphatase
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Acid phosphatase PII
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acid phosphohydrolase
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acid phosphomoesterase
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acid phosphomonoester hydrolase
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Adipocyte acid phosphatase, isozyme alpha
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Adipocyte acid phosphatase, isozyme beta
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glycerophosphatase
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Low molecular weight phosphotyrosine protein phosphatase
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Minor phosphate-irrepressible acid phosphatase
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pH 2.5 acid phosphatase
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pH 6-optimum acid phosphatase
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phosphomonoesterase
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prostatic acid phosphatase
secretory isoform
purple acid phosphatase
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Stationary-phase survival protein surE
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Tartrate-resistant acid ATPase
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tartrate-resistant acid phosphatase
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phosphate-monoester phosphohydrolase (acid optimum)
Wide specificity. Also catalyses transphosphorylations.
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mannose 6-phosphate glycoprotein + H2O
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
6,8-difluoro-4-methylumbelliferyl phosphate + H2O
6,8-difluoro-4-methylumbelliferone + phosphate
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AMP + H2O
adenosine + phosphate
at neutral pH: to a lesser extent also ATP is dephosphorylated, at pH 5.6: also ADP, and to a lesser extent ATP are dephosphorylated
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phospho-L-tyrosine + H2O
L-tyrosine + phosphate
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additional information
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ACP5 possesses a central role in removal of the mannose 6-phosphate recognition marker
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
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additional information
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ACP5 possesses a central role in removal of the mannose 6-phosphate recognition marker
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4'-O-(2-fluoromalonyl)-L-tyrosine-containing peptides
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inhibitory potency, overview
4'-O-(2-malonyl)-L-tyrosine-containing peptides
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inhibitory potency, overview
phospho-L-tyrosine peptide analogues
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inhibitory potency of several Fmoc-O,O-tert-butyl phospho-L-tyrosine analogue peptides, overview
additional information
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inhibitor-enzyme interaction
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additional information
additional information
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kinetics
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1.45
L-(+)-Tartrate
Mus musculus
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UniProt
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N1E-115
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high activity
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high activity
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trace amounts
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trace amounts
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high activity
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trace amounts
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high activity
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additional information
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the enzyme is widely expressed in many tissues, where it is associated with cells principally originating from the bone marrow, including those of osteoclast/macrophage lineage
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high activity
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Kupffer cells
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PPA5_MOUSE
327
0
36807
Swiss-Prot
Secretory Pathway (Reliability: 1 )
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45000
2 * 45000, SDS-PAGE
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homodimer
2 * 45000, SDS-PAGE
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additional information
analysis of ACP5-deficient mice reveals that levels of mannose 6-phosphate glycoproteins are highly elevated in tissues that normally express ACP5, and this results from a failure to dephosphorylate lysosomal proteins
additional information
overexpression of ACP5 in N1E-115 neuroblastoma cells leads to an increased dephosphorylation of mannose 6-phosphate glycoproteins
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immobilized metal ion affinity chromatography (Ni2+)
recombinant enzyme to over 95% purity
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expression in Spodopetra frugiperda Sf9 cells using the baculovirus infection system
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His-tagged variant expressed in Hi5 insect cells using a baculovirus expression system
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molecular biology
ACP5 possesses a central role in removal of the mannose 6-phosphate recognition marker
diagnostics
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the tartrate-resistant acid phosphatase is a histochemical marker of the osteoclast. It is also characteristic of monohistiocytes, particularly alveolar macrophages, and is associated with diverse pathological conditions, including hairy cell leukemia and AIDS encephalopathy
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Hollander, V.P.
Acid phosphatases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
449-498
1971
Bos taurus, Saccharomyces cerevisiae, Chaos carolinense, Drosophila melanogaster, Escherichia coli, Homo sapiens, Lupinus luteus, Staphylococcus aureus, Mus musculus, Neurospora crassa, Nicotiana tabacum, Rattus norvegicus, Saccharomyces mellis, Staphylococcus aureus PS 55
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Hayman, A.R.; Bune, A.J.; Bradley, J.R.; Rashbass, J.; Cox, T.M.
Osteoclastic tartrate-resistant acid phosphatase (Acp 5): its localization to dendritic cells and diverse murine tissues
J. Histochem. Cytochem.
48
219-228
2000
Mus musculus
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Valizadeh, M.; Schenk, G.; Nash, K.; Oddie, G.W.; Guddat, L.W.; Hume, D.A.; de Jersey, J.; Burke, T.R.; Hamilton, S.
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases
Arch. Biochem. Biophys.
424
154-162
2004
Homo sapiens, Ipomoea batatas, Mus musculus, Phaseolus vulgaris, Sus scrofa (P09889)
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Sun, P.; Sleat, D.E.; Lecocq, M.; Hayman, A.R.; Jadot, M.; Lobel, P.
Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins
Proc. Natl. Acad. Sci. USA
105
16590-16595
2008
Mus musculus (Q05117)
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Sowa, N.A.; Vadakkan, K.I.; Zylka, M.J.
Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception
PLoS ONE
4
e4248
2009
Mus musculus (Q8CE08), Mus musculus
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