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L-phenylalanine
10 mM, 100% inhibition
lectin
5 g/L, precipitation by lectin: 100%
-
Urea
3 mM, 100% inhibition
alendronate
-
0.01-0.1 mM, coincubation with excess Zn2+ or Mg2+ completely abolish inhibition
aspirin
-
2 mM, 84% inhibition
Cd2+
-
chronic cadmium exposure (32.5 ppm Cd2+ in purified water over 3 months) leads to noncompetitive inhibition of serum and hepatic enzyme activity. The addition of 5 mM of Zn2+ shows almost 58% reactivation of the enzyme
corticosterone
-
2 mM, 13% inhibition
L-Phe
-
maximal ainhibition at 1 mM. D-Phe has no effect
pamidronate
-
0.01-0.1 mM, coincubation with excess Zn2+ or Mg2+ completely abolish inhibition
Phe
-
20 mM, 82-99% inhibition of the soluble enzyme form, 68-95% inhibition of the particulate enzyme form
polyphenol-rich beverages
-
21% inhibition
-
progesterone
-
0.5 mM, 29% inhibition
theophylline
-
2 mM, 77% inhibition
zoledronate
-
0.01-0.1 mM, coincubation with excess Zn2+ or Mg2+ completely abolish inhibition
L-homoarginine
-
-
L-homoarginine
-
powerful inhibitor of the bone/liver/kidney isoenzyme and for the osteosarcoma cell enzyme
L-homoarginine
-
inhibition of an isozyme from the lower part of intestine
L-phenylalanine
10 mM, 100% inhibition
L-phenylalanine
10 mM, 37% inhibition
L-phenylalanine
-
2 mM, 24% inhibition
L-phenylalanine
10 mM, 37% inhibition, bone isoenzyme
L-phenylalanine
10 mM, 62% inhibition, isoenzyme rTI2A
L-phenylalanine
10 mM, 70% inhibition, isoenzyme rTI2B
lectin
5 g/L, precipitation by lectin: 100%
-
lectin
5 g/L, precipitation by lectin: 100%, bone isoenzyme
-
lectin
5 g/L, precipitation by lectin: 58%, isoenzyme rTI2B
-
lectin
5 g/L, precipitation by lectin: 76%, isoenzyme rTI2A
-
levamisole
-
0.5 mM, 91% inhibition
levamisole
-
inhibits brush border membrane enzyme activity in the upper villus but is less effective in the middle villus and has no effect on alkaline phosphatase activity in the mucus gel
levamisole
-
hydrolysis of pyrophosphate by rat aortic rings is inhibited about half by the nonspecific alkaline phosphatase inhibitor levamisole. Hydrolysis is increased in aortic rings from uremic rats and all of this increase is inhibited by levamisole
Urea
3 mM, 100% inhibition
Urea
3 mM, 68% inhibition, bone isoenzyme
Urea
3 mM, 70% inhibition, isoenzyme rTI2B
Urea
3 mM, 71% inhibition
Urea
3 mM, 80% inhibition, isoenzyme rTI2A
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Coleman, J.E.; Gettins, P.
Alkaline phosphatase, solution structure, and mechanism
Adv. Enzymol. Relat. Areas Mol. Biol.
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381-452
1983
Bacillus subtilis, Bacillus licheniformis, Bos taurus, Escherichia coli, Homo sapiens, Micrococcus sodonensis, Rattus norvegicus
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Wang, H.; Gilles-Baillien, M.
Alkaline phosphatase and ATPases in brush border membranes of rat jejunum: distinct effects of divalent cations and of some inhibitors
Arch. Int. Physiol. Biochim. Biophys.
100
289-294
1992
Rattus norvegicus
brenda
Wright, P.J.; Leathwood, P.D.; Plummer, D.T.
Enzymes in rat urine: alkaline phosphatase
Enzymologia
42
317-327
1972
Rattus norvegicus
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Manning, J.P.; Green, S.; Inglis, N.R.; Fishman, W.H.
Characterization of alkaline phosphatase from rat pregnant and pseudopregnant deciduae, fetal placentae, anestrus uteri and small intestine
Enzymologia
37
262-272
1969
Rattus norvegicus
brenda
Chandran Nair, B.; Majeska, R.J.; Rodan, G.A.
Rat alkaline phosphatase. I. Purification and characterization of the enzyme from osteosarcoma: generation of monoclonal and polyclonal antibodies
Arch. Biochem. Biophys.
254
18-27
1987
Rattus norvegicus
brenda
Yedlin, S.T.; Young, G.P.; Seetharam, B.; Seetharam, S.; Alpers, D.H.
Characterization and comparison of soluble and membranous forms of intestinal alkaline phosphatase from the suckling rat
J. Biol. Chem.
256
5620-5626
1981
Rattus norvegicus
brenda
Goldstein, D.J.; Harris, H.
Human placental alkaline phosphatase differs from that of other species
Nature
280
602-605
1979
Bos taurus, Canis lupus familiaris, Cavia porcellus, Felis catus, Ovis aries, Homo sapiens, Macaca mulatta, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Malik, N.; Butterworth, P.J.
Molecular properties of rat intestinal alkaline phosphatase
Biochim. Biophys. Acta
446
105-114
1976
Rattus norvegicus
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Say, J.C.; Ciuffi, K.; Furriel, R.P.M.; Ciancaglini, P.; Leone, F.A.
Alkaline phosphatase from rat osseous plates: purification and biochemical characterization of a soluble form
Biochim. Biophys. Acta
1074
256-262
1991
Rattus norvegicus
brenda
Fernandes, S.S.; Furriel, R.P.M.; Petenusci, S.O.; Leone, F.A.
Streptozotocin-induced diabetes: significant changes in the kinetic properties of the soluble form of rat bone alkaline phosphatase
Biochem. Pharmacol.
58
841-849
1999
Rattus norvegicus
brenda
Feldbush, T.L.; Lafrenz, D.
Alkaline phosphatase on activated B cells characterization of the expression of alkaline phosphatase on activated B cells
J. Immunol.
147
3690-3695
1991
Rattus norvegicus
brenda
Wada, H.; Yagami, I.; Niwa, N.; Hayakawa, T.; Tsuge, H.
Distribution and properties of rat intestinal alkaline phosphatase isoenzymes
Exp. Anim.
50
153-158
2001
Rattus norvegicus
brenda
Miao, D.; Scutt, A.
Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage
J. Histochem. Cytochem.
50
333-340
2002
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Vaisman, D.N.; McCarthy, A.D.; Cortizo, A.M.
Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations
Biol. Trace Elem. Res.
104
131-140
2005
Rattus norvegicus
brenda
Harada, T.; Koyama, I.; Matsunaga, T.; Kikuno, A.; Kasahara, T.; Hassimoto, M.; Alpers, D.H.; Komoda, T.
Characterization of structural and catalytic differences in rat intestinal alkaline phosphatase isozymes
FEBS J.
272
2477-2486
2005
Rattus norvegicus
brenda
Akiba, Y.; Mizumori, M.; Guth, P.H.; Engel, E.; Kaunitz, J.D.
Duodenal brush border intestinal alkaline phosphatase activity affects bicarbonate secretion in rats
Am. J. Physiol. Gastrointest. Liver Physiol.
293
G1223-G1233
2007
Rattus norvegicus
brenda
Reilly, G.C.; Radin, S.; Chen, A.T.; Ducheyne, P.
Differential alkaline phosphatase responses of rat and human bone marrow derived mesenchymal stem cells to 45S5 bioactive glass
Biomaterials
28
4091-4097
2007
Homo sapiens, Rattus norvegicus
brenda
Lee, M.W.; Muramatsu, T.; Uekusa, T.; Lee, J.H.; Shimono, M.
Heat stress induces alkaline phosphatase activity and heat shock protein 25 expression in cultured pulp cells
Int. Endod. J.
41
158-162
2008
Rattus norvegicus
brenda
Sogabe, N.; Maruyama, R.; Hosori, T.; Goseki-Sone, M.
Enhancement effects of vitamin K1 (phylloquinone) or vitamin K2 (menaquinone-4) on intestinal alkaline phosphatase activity in rats
J. Nutr. Sci. Vitaminol.
53
219-224
2007
Rattus norvegicus
brenda
Chida, K.; Taguchi, M.
Change in localization of alkaline phosphatase and mannosidase II by colchicine treatment of primary cultures of fetal rat hepatocytes
Acta Histochem. Cytochem.
41
1-5
2008
Rattus norvegicus
brenda
Taguchi, M.; Chida, K.
Effects of Colchicine on Localization of Alkaline Phosphatase in McA-RH 7777 Rat Hepatoma Cells
Acta Histochem. Cytochem.
41
149-155
2008
Rattus norvegicus
brenda
Dziedziejko, V.; Safranow, K.; Slowik-Zylka, D.; Machoy-Mokrzynska, A.; Millo, B.; Machoy, Z.; Chlubek, D.
Characterisation of rat and human tissue alkaline phosphatase isoforms by high-performance liquid chromatography and agarose gel electrophoresis
Biochimie
91
445-452
2009
Rattus norvegicus, Rattus norvegicus (P08289)
brenda
Mota, A.; Silva, P.; Neves, D.; Lemos, C.; Calhau, C.; Torres, D.; Martel, F.; Fraga, H.; Ribeiro, L.; Alcada, M.N.; Pinho, M.J.; Negrao, M.R.; Pedrosa, R.; Guerreiro, S.; Guimaraes, J.T.; Azevedo, I.; Martins, M.J.
Characterization of rat heart alkaline phosphatase isoenzymes and modulation of activity
Braz. J. Med. Biol. Res.
41
600-609
2008
Rattus norvegicus
brenda
Lomashvili, K.A.; Garg, P.; Narisawa, S.; Millan, J.L.; ONeill, W.C.
Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification
Kidney Int.
73
1024-1030
2008
Mus musculus, Rattus norvegicus
brenda
Mirhashemi, S.; Moshtaghie, A.; Ani, M.; Aarabi, M.
In vivo and in vitro studies of kinetic changes of serum, liver and brain high and low molecular weight alkaline phosphatase following aluminium exposure in rat
Asian J. Biochem.
5
1-11
2010
Rattus norvegicus
-
brenda
Trevino, S.; Andrade-Garcia, A.; Herrera Camacho, I.; Leon-Chavez, B.; Aguilar-Alonso, P.; Flores, G.; Brambila, E.
Chronic cadmium exposure lead to inhibition of serum and hepatic alkaline phosphatase activity in Wistar rats
J. Biochem. Mol. Toxicol.
29
587-594
2015
Rattus norvegicus
brenda