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1,2-dioleoyl-sn-glycerol + H2O
2-oleoylglycerol + oleate
-
-
-
-
?
1,2-dioleoyl-sn-glycerol + H2O
2-oleylglycerol + oleate
-
-
-
-
?
1,2-dioleoyl-sn-glycerol + H2O
?
-
-
-
-
?
1,2-dioleoylglycerol + H2O
2-oleoylglycerol + oleate
-
-
mayor end product of trioleoylglycerol and 1,2-dioleoylglycerol hydrolysis
-
?
1-monooleoylglycerol + H2O
glycerol + oleate
-
3times higher activity than with 2-oleoylglycerol
-
-
?
2-monooleoylglycerol + H2O
glycerol + oleate
-
-
-
-
?
4-nitrophenyl oleate + H2O
4-nitrophenol + oleate
-
-
-
-
?
cholesterol oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
cholesteryl oleate + H2O
cholesterol + oleic acid
-
-
-
-
?
diacylglycerol + H2O
monoacylglycerol + a carboxylate
-
-
-
-
?
dioleoylglycerol + H2O
monooleoylglycerol + oleate
-
-
-
-
?
lipid emulsion + H2O
fatty acids
-
recombinant HSL, the release of fatty acids is only slightly affected by their degree of unsaturation
fatty acids ranging in chain length from 12 to 24 carbon atoms and in unsaturation from 0 to 6 double bonds
-
?
monoacylglycerol + H2O
glycerol + a carboxylate
-
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
-
?
triacylglycerol + H2O
diacylglycerol + a carboxylate
-
-
-
-
?
triolein + H2O
diolein + oleate
-
-
-
-
?
triolein + H2O
dioleoylglycerol + oleate
-
-
-
-
?
trioleoylglycerol + H2O
1,2-dioleoylglycerol + oleate
-
-
-
-
?
trioleoylglycerol + H2O
dioleoylglycerol + oleate
additional information
?
-
cholesteryl oleate + H2O
cholesterol + oleate
-
-
-
-
?
cholesteryl oleate + H2O
cholesterol + oleate
-
approx. 55% of activity with dioleoylglcerol
-
-
?
trioleoylglycerol + H2O
dioleoylglycerol + oleate
-
-
-
-
?
trioleoylglycerol + H2O
dioleoylglycerol + oleate
-
approx. 16% of activity with dioleoylglcerol
-
-
?
trioleoylglycerol + H2O
dioleoylglycerol + oleate
-
the type of dietary fat has no effect on kinetic properties of hormone-sensitive lipase
-
-
?
additional information
?
-
-
expressed at a higher level in oxidative fibres than in glycolytic fibres. The two physiological stimuli adrenaline and contraction increase enzyme activity in muscle, and the effects are partially additive. Adrenaline acts via beta-adrenergic activation of cAMP-dependent protein kinase, while the effect of contractions is mediated by protein kinase C, at least partly via the extracellular signal-regulated kinase pathway. Endurance training diminishes the sensitivity of muscle hormone-sensitive lipase to adrenaline but increases the contraction-mediated activation
-
-
?
additional information
?
-
key enzyme in fatty acid mobilization
-
-
?
additional information
?
-
-
rate-limiting enzyme in lipolysis
-
-
?
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Yeaman, S.J.
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2004
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
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Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle
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441
219-228
1998
Rattus norvegicus
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Holm, C.; Belfrage, P.; Fredrikson, G.
Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue
Biochem. Biophys. Res. Commun.
148
99-105
1987
Rattus norvegicus
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Langfort, J.; Ploug, T.; Ihlemann, J.; Saldo, M.; Holm, C.; Galbo, H.
Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle
Biochem. J.
340
459-465
1999
Rattus norvegicus
-
brenda
Pease, R.J.; Wiggins, D.; Saggerson, E.D.; Tree, J.; Gibbons, G.F.
Metabolic characteristics of a human hepatoma cell line stably transfected with hormone-sensitive lipase
Biochem. J.
341
453-460
1999
Rattus norvegicus
-
brenda
Shen, W.J.; Patel, S.; Natu, V.; Kraemer, F.B.
Mutational analysis of structural features of rat hormone-sensitive lipase
Biochemistry
37
8973-8979
1998
Rattus norvegicus
brenda
Shen, W.J.; Patel, S.; Hong, R.; Kraemer, F.B.
Hormone-sensitive lipase functions as an oligomer
Biochemistry
39
2392-2398
2000
Rattus norvegicus
brenda
Holm, C.; Belfrage, P.; Fredrikson, G.
Human adipose tissue hormone-sensitive lipase: identification and comparison with other species
Biochim. Biophys. Acta
1006
193-197
1989
Homo sapiens, Rattus norvegicus
brenda
Small, C.A.; Yeaman, S.J.; West, D.W.; Clegg, R.A.
Cholesterol ester hydrolysis and hormone-sensitive lipase in lactating rat mammary tissue
Biochim. Biophys. Acta
1082
251-254
1991
Rattus norvegicus
brenda
Osterlund, T.
Structure-function relationships of hormone-sensitive lipase
Eur. J. Biochem.
268
1899-1907
2001
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Holm, C.; Davis, R.C.; Fredrikson, G.; Belfrage, P.; Schotz, M.C.
Expression of biologically active hormone-sensitive lipase in mammalian (COS) cells
FEBS Lett.
285
139-144
1991
Rattus norvegicus
brenda
Fredrikson, G.; Belfrage, P.
Positional specificity of hormone-sensitive lipase from rat adipose tissue
J. Biol. Chem.
258
14253-14256
1983
Rattus norvegicus
brenda
Raclot, T.; Holm, C.; Langin, D.
Fatty acid specificity of hormone-sensitive lipase: implication in the selective hydrolysis of triacylglycerols
J. Lipid Res.
42
2049-2057
2001
Homo sapiens, Rattus norvegicus
brenda
Awad, A.B.; Chattopadhyay, J.P.
Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes
J. Nutr.
116
1095-1100
1986
Rattus norvegicus
brenda
Holm, C.; Belfrage, P.; Osterlund, T.; Davis, R.C.; Schotz, M.C.; Langin, D.
Hormone-sensitive lipase: structure, function, evolution and overproduction in insect cells using the baculovirus expression system
Protein Eng.
7
537-541
1994
Rattus norvegicus
brenda
Wang, J.; Shen, W.J.; Patel, S.; Harada, K.; Kraemer, F.B.
Mutational analysis of the "regulatory module" of hormone-sensitive lipase
Biochemistry
44
1953-1959
2005
Rattus norvegicus
brenda
Lindvall, H.; Nevsten, P.; Stroem, K.; Wallenberg, R.; Sundler, F.; Langin, D.; Soerhede Winzell, M.; Holm, C.
A novel hormone-sensitive lipase isoform expressed in pancreatic beta-cells
J. Biol. Chem.
279
3828-3836
2004
Rattus norvegicus (Q6T861)
brenda
Martin-Hidalgo, A.; Huerta, L.; Alvarez, N.; Alegria, G.; Del Val Toledo, M.; Herrera, E.
Expression, activity, and localization of hormone-sensitive lipase in rat mammary gland during pregnancy and lactation
J. Lipid Res.
46
658-668
2005
Rattus norvegicus
brenda
Donsmark, M.; Langfort, J.; Holm, C.; Ploug, T.; Galbo, H.
Regulation and role of hormone-sensitive lipase in rat skeletal muscle
Proc. Nutr. Soc.
63
309-314
2004
Rattus norvegicus
brenda
Lobo, M.V.; Huerta, L.; Arenas, M.I.; Busto, R.; Lasuncion, M.A.; Martin-Hidalgo, A.
Hormone-sensitive lipase expression and IHC localization in the rat ovary, oviduct, and uterus
J. Histochem. Cytochem.
57
51-60
2009
Rattus norvegicus (P15304)
brenda
Langfort, J.; Jagsz, S.; Dobrzyn, P.; Brzezinska, Z.; Klapcinska, B.; Galbo, H.; Gorski, J.
Testosterone affects hormone-sensitive lipase (HSL) activity and lipid metabolism in the left ventricle
Biochem. Biophys. Res. Commun.
399
670-676
2010
Rattus norvegicus
brenda
Ogasawara, J.; Nomura, S.; Rahman, N.; Sakurai, T.; Kizaki, T.; Izawa, T.; Ishida, H.; Haga, S.; Ohno, H.
Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes
Biochem. Biophys. Res. Commun.
400
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2010
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Vasilieva, E.; Dutta, S.; Malla, R.K.; Martin, B.P.; Spilling, C.D.; Dupureur, C.M.
Rat hormone sensitive lipase inhibition by cyclipostins and their analogs
Bioorg. Med. Chem.
23
944-952
2015
Rattus norvegicus
brenda