Information on EC 2.8.3.11 - citramalate CoA-transferase

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The expected taxonomic range for this enzyme is: Bacteria

EC NUMBER
COMMENTARY
2.8.3.11
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RECOMMENDED NAME
GeneOntology No.
citramalate CoA-transferase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA
show the reaction diagram
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-
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-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
coenzyme A transfer
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-
-
-
PATHWAY
KEGG Link
MetaCyc Link
C5-Branched dibasic acid metabolism
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:citramalate CoA-transferase
The enzyme is a component of EC 4.1.3.22 citramalate lyase. Also catalyses the transfer of thioacyl carrier protein from its acetyl thioester to citramalate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
citramalyl-CoA transferase
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-
citramalyl-CoA transferase
Achromobacter xylosoxidans IL142
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-
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coenzyme A-transferase, citramalate
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CAS REGISTRY NUMBER
COMMENTARY
9033-60-7
indistinguishable from EC 2.8.3.7 in Chemical Abstracts
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Achromobacter xylosoxidans IL142
strain IL142
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-
Manually annotated by BRENDA team
alpha-subunit of the citramalate enzyme complex
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-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + citramalate
acetate + (3S)-citramalyl-CoA
show the reaction diagram
-
alpha-subunit of the citramalate enzyme complex
-
r
succinate + (3S)-citramalyl-CoA
succinyl-CoA + citramalate
show the reaction diagram
Achromobacter xylosoxidans, Achromobacter xylosoxidans IL142
-
99.9% enantiomeric purity
-
r
succinate + (S)-(+)-citramalyl-CoA
succinyl-CoA + citramalate
show the reaction diagram
Achromobacter xylosoxidans, Achromobacter xylosoxidans IL142
-
99.9% enantiomeric purity
-
r
acetyl-[acyl-carrier protein] + citramalate
citramalyl-[acyl-carrier protein] + acetate
show the reaction diagram
-
substrate is the acetylated acyl carrier protein of citrate lyase or citramalate lyase enzyme complex, biological significant reaction, alpha-subunit of citramalate lyase enzyme complex
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-
?
additional information
?
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no substrate: citrate, also catalyses citramalate dependent exchange reaction between acetate and acetyl-CoA
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-[acyl-carrier protein] + citramalate
citramalyl-[acyl-carrier protein] + acetate
show the reaction diagram
-
biological significant reaction, alpha-subunit of citramalate lyase enzyme complex
-
-
?
succinate + (S)-(+)-citramalyl-CoA
succinyl-CoA + citramalate
show the reaction diagram
Achromobacter xylosoxidans, Achromobacter xylosoxidans IL142
-
99.9% enantiomeric purity
-
r
ACTIVATING COMPOUND
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
ATP
-
activity is enhanced in presence of CoA and succinate
CoA
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activity is enhanced in presence of ATP and succinate
succinate
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activity is enhanced in presence of CoA and ATP
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
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-
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pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
Renatured/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
reconstitution of the enzyme complex at pH 8.0, 25°C
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APPLICATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
biotechnology
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production process of enantiomeric pure (S)-(+)-citramalic acid from itaconic acid
biotechnology
Achromobacter xylosoxidans IL142
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production process of enantiomeric pure (S)-(+)-citramalic acid from itaconic acid
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