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Disease on EC 2.7.11.4 - [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.
Carcinogenesis
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer.
Carcinoma, Hepatocellular
APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.
Regulation of branched-chain alpha-keto acid dehydrogenase kinase gene expression by glucocorticoids in hepatoma cells and rat liver.
Colorectal Neoplasms
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer.
Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer.
Diabetes Mellitus
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease.
Diabetes Mellitus, Type 2
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease.
Epilepsy
Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy.
Hepatitis
Branched chain ?-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice.
Hyperthyroidism
Experimental hyperthyroidism causes inactivation of the branched-chain alpha-ketoacid dehydrogenase complex in rat liver.
Intellectual Disability
Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy.
The ubiquitin ligase UBE3B, disrupted in intellectual disability and absent speech, regulates metabolic pathways by targeting BCKDK.
Liver Diseases
Branched chain ?-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice.
Maple Syrup Urine Disease
Dataset reporting BCKDK interference in a BCAA-catabolism restricted environment.
Metabolic Diseases
BCKDK: an emerging kinase target for metabolic diseases and cancer.
Microcephaly
Two Novel Mutations in the BCKDK (Branched-Chain Keto-Acid Dehydrogenase Kinase) Gene Are Responsible for a Neurobehavioral Deficit in Two Pediatric Unrelated Patients.
Myocarditis
Branched chain ?-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice.
Neoplasm Metastasis
APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.
Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer.
Neoplasms
BCKDK: an emerging kinase target for metabolic diseases and cancer.
Obesity
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.
Parkinson Disease
Association of three candidate genetic variants in ACMSD/TMEM163, GPNMB and BCKDK /STX1B with sporadic Parkinson's disease in Han Chinese.
Pheochromocytoma
Leucine toxicity in a neuronal cell model with inhibited branched chain amino acid catabolism.
Protein Deficiency
A new family of protein kinases--the mitochondrial protein kinases.
Effect of dietary protein on the liver content and subunit composition of the branched-chain alpha-ketoacid dehydrogenase complex.
Physiological covalent regulation of rat liver branched-chain alpha-ketoacid dehydrogenase.
Renal Insufficiency
Differential regulation of branched-chain alpha-ketoacid dehydrogenase kinase expression by glucocorticoids and acidification in LLC-PK1-GR101 cells.
Sepsis
The plasma levels of CST and BCKDK in patients with sepsis.
Starvation
Effects of low-protein diet and starvation on the activity of branched-chain 2-oxo acid dehydrogenase kinase in rat liver and heart.
Hepatic branched-chain alpha-keto acid dehydrogenase complex in female rats: activation by exercise and starvation.
Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases.
Regulation of branched-chain alpha-keto acid dehydrogenase kinase expression in rat liver.
Triple Negative Breast Neoplasms
Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity.