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Information on EC 2.7.11.1 - non-specific serine/threonine protein kinase and Organism(s) Corynebacterium glutamicum and UniProt Accession Q8NU97

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IUBMB Comments
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
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This record set is specific for:
Corynebacterium glutamicum
UNIPROT: Q8NU97
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Word Map
The taxonomic range for the selected organisms is: Corynebacterium glutamicum
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
protein kinase a, 14-3-3, camkii, p-akt, lrrk2, c-jun n-terminal kinase, serine/threonine kinase, raf-1, protein kinase b, gsk-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
serine/threonine protein kinase
-
A-kinase
-
-
-
-
A-T, mutated
-
-
-
-
A-T, mutated homolog
-
-
-
-
AMH type II receptor
-
-
-
-
Anti-sigma B factor rsbT
-
-
-
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AP50 kinase
-
-
-
-
Ataxia telangiectasia mutated
-
-
-
-
Ataxia telangiectasia mutated homolog
-
-
-
-
ATP-protein transphosphorylase
-
-
-
-
betaIIPKC
-
-
-
-
Breast-tumor-amplified kinase
-
-
-
-
Calcium-dependent protein kinase C
-
-
-
-
Calcium/phospholipid-dependent protein kinase
-
-
-
-
cAMP-dependent protein kinase A
-
-
-
-
casein kinase
-
-
-
-
casein kinase 2
-
-
-
-
casein kinase I
-
-
-
-
casein kinase II
-
-
-
-
casein kinase-2
-
-
-
-
CDC25 suppressing protein kinase
-
-
-
-
Cell division cycle 2-like
-
-
-
-
CK-2
-
-
-
-
CK2
-
-
-
-
CK2-alpha
-
-
-
-
CKI
-
-
-
-
CKII
-
-
-
-
CLP-36 interacting kinase
-
-
-
-
cyclic monophosphate-dependent protein kinase
-
-
-
-
cyclic nucleotide-dependent protein kinase
-
-
-
-
cyclin-dependent kinase
-
-
-
-
cytidine 3',5'-cyclic monophosphate-responsive protein kinase
-
-
-
-
DNA-PKcs
-
-
-
-
DNPK1
-
-
-
-
dSTPK61
-
-
-
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G11 protein
-
-
-
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hARK1
-
-
-
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histone kinase
-
-
-
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hPDK1
-
-
-
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Hpr kinase
-
-
-
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hPSK
-
-
-
-
HSPK 21
-
-
-
-
HSPK 36
-
-
-
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hydroxyalkyl-protein kinase
-
-
-
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Kinase interacting with stathmin
-
-
-
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kinase, casein (phosphorylating)
-
-
-
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kinase, protamine (phosphorylating)
-
-
-
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kinase, protein (phosphorylating)
-
-
-
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kinase, protein, A (phosphorylating)
-
-
-
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kinase, protein, C (phosphorylating)
-
-
-
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Lymphocyte-oriented kinase
-
-
-
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M phase-specific cdc2 kinase
-
-
-
-
mitogen-activated S6 kinase
-
-
-
-
mPDK1
-
-
-
-
MPSK
-
-
-
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Myristoylated and palmitoylated serine-threonine kinase
-
-
-
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NY-REN-55 antigen
-
-
-
-
P-CIP2
-
-
-
-
P460
-
-
-
-
p46Eg265
-
-
-
-
p46XlEg22
-
-
-
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p82 kinase
-
-
-
-
pEg2
-
-
-
-
phosphorylase b kinase kinase
-
-
-
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Phototropin
-
-
-
-
Pim-2h
-
-
-
-
PKA
-
-
-
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PkB kinase
-
-
-
-
pp39-mos
-
-
-
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Pre-mRNA protein kinase
-
-
-
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protamine kinase
-
-
-
-
protein glutamyl kinase
-
-
-
-
protein kinase (phosphorylating)
-
-
-
-
Protein kinase B kinase
-
-
-
-
protein kinase CK2
-
-
-
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Protein kinase Krct
-
-
-
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Protein kinase MST
-
-
-
-
protein kinase p58
-
-
-
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Protein kinase PKL12
-
-
-
-
protein phosphokinase
-
-
-
-
protein serine kinase
-
-
-
-
protein serine-threonine kinase
-
-
-
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protein-aspartyl kinase
-
-
-
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protein-cysteine kinase
-
-
-
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protein-serine kinase
-
-
-
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protein-serine/threonine kinase
-
-
-
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PRP4 kinase
-
-
-
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PRP4 pre-mRNA processing factor 4 homolog
-
-
-
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PSK-H1
-
-
-
-
Raf kinase
-
-
-
-
Raf-1
-
-
-
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ratAurA
-
-
-
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ribosomal protein S6 kinase II
-
-
-
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ribosomal S6 protein kinase
-
-
-
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RP1 protein
-
-
-
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S-receptor kinase
-
-
-
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serine kinase
-
-
-
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serine protein kinase
-
-
-
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serine(threonine) protein kinase
-
-
-
-
serine-specific protein kinase
-
-
-
-
serine/threonine kinase
-
-
-
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Serine/threonine kinase 15
-
-
-
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Serine/threonine kinase Ayk1
-
-
-
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serine/threonine protein kinase
Serine/threonine-protein kinase NRK2
-
-
-
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Serine/threonine-protein kinase NYD-SPK
-
-
-
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SRK
-
-
-
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Ste20-like kinase
-
-
-
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STE20-like kinase MST1
-
-
-
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STE20-like kinase MST2
-
-
-
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STE20-like kinase MST3
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-
-
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Switch protein/serine kinase
-
-
-
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T-antigen kinase
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-
-
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threonine-specific protein kinase
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-
-
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Twitchin kinase
-
-
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type-2 casein kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (non-specific)
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analysed to date.
CAS REGISTRY NUMBER
COMMENTARY hide
191808-15-8
phosphoinositide dependent protein kinase 1
340830-03-7
-
37278-10-7
-
377752-08-4
ribosomal protein S6 kinase 2
389133-24-8
ribosomal S6 kinase 3
52660-18-1
casein kinase, protein kinase CK2
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
90698-26-3
ribosomal protein S6 kinase 1
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + PknG
ADP + phosphorylated-PknG
show the reaction diagram
activation of PknG is part of a phosphorylation cascade mechanism that relies on PknA activity
-
-
?
ATP + OdhI
ADP + phosphorylated-OdhI
show the reaction diagram
following phosphorylation by PknA, PknG can transphosphorylate its specific substrate 2-oxoglutarate dehydrogenase inhibitor protein (OdhI) in vitro
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
PknA
activation of PknG is part of a phosphorylation cascade mechanism that relies on PknA activity
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
enzyme possesses autokinase activity. Phosphorylated resiudes: Thr179, Thr181, Ser228, Ser229, Ser231, Thr292, Thr298, Thr319, Thr321
phosphoprotein
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
molecular biology
pknA and pknB are key players in signal transduction pathways for the regulation of the cell shape and both are essential for sustaining corynebacterial growth
molecular biology
pknA and pknB are key players in signal transduction pathways for the regulation of the cell shape and both are essential for sustaining corynebacterial growth
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fiuza, M.; Canova, M.J.; Zanella-Cleon, I.; Becchi, M.; Cozzone, A.J.; Mateos, L.M.; Kremer, L.; Gil, J.A.; Molle, V.
From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division
J. Biol. Chem.
283
18099-18112
2008
Corynebacterium glutamicum (A0A160PV21), Corynebacterium glutamicum (Q8NM29), Corynebacterium glutamicum (Q8NU97), Corynebacterium glutamicum (Q8NU98)
Manually annotated by BRENDA team