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Information on EC 2.7.1.150 - 1-phosphatidylinositol-3-phosphate 5-kinase and Organism(s) Homo sapiens and UniProt Accession Q9Y2I7

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Homo sapiens
UNIPROT: Q9Y2I7 not found.
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
pikfyve, ste12, fab1p, pip5k3, fab1/pikfyve, phosphatidylinositol 3-phosphate 5-kinase, ppk-3, phosphatidylinositol-3-phosphate-5-kinase pikfyve, ptdins3p 5-kinase, cgfab1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
class III lipid kinase
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phosphatidylinositol 3-phosphate 5-kinase
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phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase
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PI-3P-5-kinase
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Fab1p
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-
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kinase (phosphorylating), phosphatidylinositol 3-phosphate 5-
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phosphatidylinositol 3-phosphate 5-kinase
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-
-
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phosphatidylinositol 5-OH kinase
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Phosphatidylinositol-3-phosphate 5-kinase
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-
-
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phosphatidylinositol-3-phosphate-5-kinase PIKfyve
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PI(3)P-5-kinase
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-
-
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PIKfyve
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PIP5K3
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PtdIns(3) 5-kinase
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-
-
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PtdIns3P 5-OH kinase
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type III PIP kinase
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-
-
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additional information
-
the enzyme belongs to the type III PIPkin family
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho-group transfer
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-
-
-
PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
190606-24-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
PIKfyve participates in the SGK1-dependent regulation of the Na+, glucose cotransporter SGLT1 (SLC5A1)
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
PIKfyve participates in the SGK1-dependent regulation of the Na+, glucose cotransporter SGLT1 (SLC5A1)
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
apilimod
-
vacuolin-1
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
enzyme synthesis is stimulated by a hyperosmotic shock
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
astroglial SVG-A derived cells
Manually annotated by BRENDA team
astroglial-derived cells
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
localizes mainly to early endosomes. PIKfyve is distributed in microdomains
Manually annotated by BRENDA team
-
PIKfyve is predominantly associated with the early endosome, from where it regulates retrograde membrane trafficking to the trans-Golgi-network
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the intracellular trafficking of pathogens, Zaire EBOV GP (VSV-MeGFPZEBOV) and SARS-CoV-2 S Wuhan-Hu-1 strain (VSV-eGFP-SARS-CoV-2), is elicited by inhibition of PIKfyve kinase via apilimod and vacuolin-1, small-molecule inhibitors of the main endosomal phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, PIKfyve
physiological function
analysis of the intracellular trafficking of pathogens elicited by inhibition of PIKfyve kinase
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FYV1_HUMAN
2098
0
237136
Swiss-Prot
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
237000
calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
the PIPkin type III family enzyme consists of 4 typical domains: the FYVE RING Zn-finger domain, the TCP-I/chaperone-like domain, the PIPkin domain, and the cysteine-rich domain, the human enzyme contains additionally a DEP domain
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cooke, F.T.
Phosphatidylinositol 3,5-bisphosphate: metabolism and function
Arch. Biochem. Biophys.
407
143-151
2002
Arabidopsis thaliana, Caenorhabditis elegans, Candida albicans, Drosophila melanogaster, Homo sapiens, Mus musculus, Oryza sativa, Schizosaccharomyces pombe, Saccharomyces cerevisiae (P34756)
Manually annotated by BRENDA team
Shojaiefard, M.; Strutz-Seebohm, N.; Tavare, J.M.; Seebohm, G.; Lang, F.
Regulation of the Na(+), glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1
Biochem. Biophys. Res. Commun.
359
843-847
2007
Homo sapiens
Manually annotated by BRENDA team
Cabezas, A.; Pattni, K.; Stenmark, H.
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1
Gene
371
34-41
2006
Homo sapiens (Q9Y2I7), Homo sapiens
Manually annotated by BRENDA team
Rutherford, A.C.; Traer, C.; Wassmer, T.; Pattni, K.; Bujny, M.V.; Carlton, J.G.; Stenmark, H.; Cullen, P.J.
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
J. Cell Sci.
119
3944-3957
2006
Homo sapiens
Manually annotated by BRENDA team
Kang, Y.L.; Chou, Y.Y.; Rothlauf, P.W.; Liu, Z.; Soh, T.K.; Cureton, D.; Case, J.B.; Chen, R.E.; Diamond, M.S.; Whelan, S.P.J.; Kirchhausen, T.
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Proc. Natl. Acad. Sci. USA
117
20803-20813
2020
Homo sapiens (Q9Y2I7)
Manually annotated by BRENDA team