Information on EC 2.6.1.3 - cysteine transaminase

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The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY
2.6.1.3
-
RECOMMENDED NAME
GeneOntology No.
cysteine transaminase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
-
-
hydrogen sulfide biosynthesis I
-
-
L-cysteine degradation III
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
L-cysteine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
aminotransferase, cysteine
-
-
-
-
CGT
-
-
-
-
cysteine aminotransferase
-
-
-
-
L-cysteine aminotransferase
-
-
-
-
L-cysteine-2-oxoglutarate aminotransferase
-
-
-
-
additional information
-
cytosolic cysteine aminotransferase, EC 2.6.1.3, is identical with cytosolic aspartate aminotransferase, EC 2.6.1.1
CAS REGISTRY NUMBER
COMMENTARY
9030-32-4
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine 3-sulfinic acid + 2-oxoglutarate
pyruvate 3-sulfinic acid + L-glutamate
show the reaction diagram
-
at pH 8.0
-
?
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
-
-
?
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
-
-
r
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
important part of enzyme together with beta-mercaptopyruvate sulfurtransferase in the regulation of thiosulfate formation
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
-
-
r
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
important part of enzyme together with beta-mercaptopyruvate sulfurtransferase in the regulation of thiosulfate formation
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
pyridoxal phosphate protein
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
alpha-Methyl-DL-cysteine
-
inhibits transamination of cysteine
L-aspartate
-
-
sodium phosphate buffer
-
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.06
2-oxoglutarate
-
-
22.2
L-cysteine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7 - 11
-
about 60% of activity maximum at pH 7 and 11
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
74000
-
gel filtration
639955
83500
-
gel filtration
639954
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer
-
1 * 84000, SDS-PAGE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
-
1 h at room temperature, complete inactivation
639954
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20ŗC, 68% inactivated after 32 days
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
TEAE-cellulose, isoelectric focusing
-