Information on EC 2.6.1.3 - cysteine transaminase

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The expected taxonomic range for this enzyme is: Rattus norvegicus

EC NUMBER
COMMENTARY
2.6.1.3
-
RECOMMENDED NAME
GeneOntology No.
cysteine transaminase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
-
hydrogen sulfide biosynthesis
-
L-cysteine degradation III
-
Metabolic pathways
-
SYSTEMATIC NAME
IUBMB Comments
L-cysteine:2-oxoglutarate aminotransferase
A pyridoxal-phosphate protein.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminotransferase, cysteine
-
-
-
-
CGT
-
-
-
-
cysteine aminotransferase
-
-
-
-
L-cysteine aminotransferase
-
-
-
-
L-cysteine-2-oxoglutarate aminotransferase
-
-
-
-
additional information
-
cytosolic cysteine aminotransferase, EC 2.6.1.3, is identical with cytosolic aspartate aminotransferase, EC 2.6.1.1
CAS REGISTRY NUMBER
COMMENTARY
9030-32-4
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-alanine 3-sulfinic acid + 2-oxoglutarate
pyruvate 3-sulfinic acid + L-glutamate
show the reaction diagram
-
at pH 8.0
-
?
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
-
-
?
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
-
-
r
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
important part of enzyme together with beta-mercaptopyruvate sulfurtransferase in the regulation of thiosulfate formation
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
-
-
r
L-cysteine + 2-oxoglutarate
L-glutamate + beta-mercaptopyruvate
show the reaction diagram
-
important part of enzyme together with beta-mercaptopyruvate sulfurtransferase in the regulation of thiosulfate formation
-
?
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
pyridoxal phosphate protein
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
alpha-Methyl-DL-cysteine
-
inhibits transamination of cysteine
Maleate
-
-
-
sodium phosphate buffer
-
-
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.06
-
2-oxoglutarate
-
-
22.2
-
L-cysteine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7
11
-
about 60% of activity maximum at pH 7 and 11
TEMPERATURE OPTIMUM
TEMPERATURE OPTIMUM MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
37
-
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
74000
-
-
gel filtration
83500
-
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
monomer
-
1 * 84000, SDS-PAGE
TEMPERATURE STABILITY
TEMPERATURE STABILITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
-
-
1 h at room temperature, complete inactivation
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-20ŗC, 68% inactivated after 32 days
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
TEAE-cellulose, isoelectric focusing
-