Reference on EC 2.4.2.14 - amidophosphoribosyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Holmes, E.W.; King, G.L.; Leyva, A.; Singer, S.C.
A purine auxotroph deficient in phosphoribosylpyrophosphate amidotransferase and phosphoribosylpyrophosphate aminotransferase activities with normal activity of ribose-5-phosphate aminotransferase
Proc. Natl. Acad. Sci. USA
73
2458-2461
1976
Cricetulus griseus
Caskey, C.T.; Ashton, D.M.; Wyngaarden, J.B.
The enzymology of feedback inhibition of glutamine phosphoribosylpyrophosphate amidotransferase by purine ribonucleotides
J. Biol. Chem.
239
2570-2579
1964
Columba livia, Rattus norvegicus
Hartman, S.C.; Buchanan, J.M.
Biosynthesis of purines. XXI. 5-phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
233
451-455
1958
Columba livia
Messenger, L.J.; Zalkin, H.
Glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli. Purification and properties
J. Biol. Chem.
254
3382-3392
1979
Escherichia coli
Wong, J.Y.; Bernlohr, D.A.; Turnbough, C.L.; Switzer, R.L.
Purification and properties of glutamine phosphoribosylpyrophosphate amidotransferase from Bacillus subtilis
Biochemistry
20
5669-5674
1981
Bacillus subtilis
Wong, J.Y.; Switzer, R.L.
Affinity chromatography of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase
Arch. Biochem. Biophys.
196
134-137
1979
Bacillus subtilis
Liras, A.; Argomaniz, L.; Llorente, P.
Presence, preliminary properties and partial purification of 5-phosphoribosylpyrophosphate amidotransferase from Artemia sp
Biochim. Biophys. Acta
1033
114-117
1990
BRENDA: Artemia sp.
Textmining: Artemia
Tsuda, M.; Katunuma, N.; Weber, G.
Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate amidotransferase [EC 2.4.2.14]. Purification and properties
J. Biochem.
85
1347-1354
1979
BRENDA: Rattus norvegicus
Textmining: Rattus
Wood, A.W.; Seegmiller, J.E.
Properties of 5-phosphoribosyl-1-pyrophosphate amidotransferase from human lymphoblasts
J. Biol. Chem.
248
138-143
1973
Homo sapiens
Bernlohr, D.A.; Switzer, R.L.
Reaction of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase with oxygen: chemistry and regulation by ligands
Biochemistry
20
5675-5681
1981
Bacillus subtilis
Holmes, E.W.
Kinetic, physical, and regulatory properties of amidophosphoribosyltransferase
Adv. Enzyme Regul.
19
215-231
1981
Bacillus subtilis, Cricetulus griseus, Columba livia, Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus
Zalkin, H.
Structure, function, and regulation of amidophosphoribosyltransferase from prokaryotes
Adv. Enzyme Regul.
21
225-237
1983
BRENDA: Bacillus subtilis, Gallus gallus, Escherichia coli
Textmining: Bacteria, eukaryota
Itoh, R.; Holmes, E.W.; Wyngaarden, J.B.
Pigeon liver amidophosphoribosyltransferase. Ligand-induced alterations in molecular and kinetic properties
J. Biol. Chem.
251
2234-2240
1976
Columba livia
Holmes, E.W.; McDonald, J.A.; McCord, J.M.; Wyngaarden, J.B.; Kelley, W.N.
Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties
J. Biol. Chem.
248
144-150
1973
Homo sapiens
King, G.L.; Boounous, C.G.; Holmes, E.W.
Human placental amidophosphoribosyltransferase. Comparison of the kinetics of glutamine and ammonia utilization
J. Biol. Chem.
253
3933-3938
1978
Homo sapiens
Onate, Y.A.; Vollmer, S.J.; Switzer, R.L.; Johnson, M.K.
Spectroscopic characterization of the iron-sulfur cluster in Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
264
18386-18391
1989
BRENDA: Bacillus subtilis
Textmining: Electron
Reynoldds, P.H.S.; Blevins, D.G.; Randall, D.D.
5-Phosphoribosylpyrophosphate amidotransferase from soybean root nodules: kinetic and regulatory properties
Arch. Biochem. Biophys.
229
623-631
1984
BRENDA: Glycine max
Textmining: plant
Nagy, M.; Reichert, U.; Ribet, A.M.
Regulation of purine metabolism in Schizosaccharomyces pombe. IV. Variations in the stability and kinetic parameters of amidophosphoribosyltransferase depending on growth phase and growth conditions
Biochim. Biophys. Acta
370
85-95
1974
Schizosaccharomyces pombe
Itoh, R.; Gorai, I.; Usami, C.; Tsushima, K.
Chicken liver amidophosphoribosyltransferase. Ligand-induced alterations in molecular properties
Biochim. Biophys. Acta
581
142-152
1979
Gallus gallus
Zhou, G.; Charbonneau, H.; Colman, R.F.; Zalkin, H.
Identification of sites for feedback regulation of glutamine 5-phosphoribosylpyrophosphate amidotransferase by nucleotides and relationship to residues important for catalysis
J. Biol. Chem.
268
10471-10481
1993
Escherichia coli
Taha, T.S.; Deits, T.L.
Detection of glycinamide ribonucleotide by HPLC with pulsed amperometry: application to the assay for glutamine: 5-phosphoribosyl-1-pyrophosphate amidotransferase (EC 2.4.2.14)
Anal. Biochem.
213
323-328
1993
Glycine max
Zhou, G.; Smith, J.L.; Zalkin, H.
Binding of purine nucleotides to two regulatory sites results in synergistic feedback inhibition of glutamine 5-phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
269
6784-6789
1994
Escherichia coli
Kim, J.H.; Wolle, D.; Haridas, K.; Parry, R.J.; Smith, J.L.; Zalkin, H.
A stable carbocyclic analog of 5-phosphoribosyl-1-pyrophosphate to probe the mechanism of catalysis and regulation of glutamine phosphoribosylpyrophosphate amidotransferase
J. Biol. Chem.
270
17394-17399
1995
Escherichia coli
Kim, J.H.; Krahn, J.M.; Tomchick, D.R.; Smith, J.L.; Zalkin, H.
Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site
J. Biol. Chem.
271
15549-15557
1996
Escherichia coli
Schoettle, S.L.; Crisp, L.B.; Szabados, E.; Christopherson, R.I.
Mechanisms of inhibition of amido phosphoribosyltransferase from mouse L1210 leukemia cells
Biochemistry
36
6377-6383
1997
Mus musculus
Chen, S.; Tomchick, D.R.; Wolle, D.; Hu, P.; Smith, J.L.; Switzer, R.L.; Zalkin, H.
Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides
Biochemistry
36
10718-10726
1997
Bacillus subtilis (P00497), Bacillus subtilis
Muchmore, C.R.; Krahn, J.M.; Kim, J.H.; Zalkin, H.; Smith, J.L.
Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli
Protein Sci.
7
39-51
1998
Bacillus subtilis, Escherichia coli
Kian, I.A.; Etingof, R.N.
Purine biosynthesis de novo in bovine retina: purification and characterization of amidophosphoribosyl transferase and phosphoribosyl pyrophosphate synthetase
Biochemistry
64
648-651
1999
Bos taurus
Bera, A.K.; Chen, S.; Smith, J.L.; Zalkin, H.
Temperature-dependent function of the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel and coupling with glycinamide ribonucleotide synthetase in a hyperthermophile
J. Bacteriol.
182
3734-3739
2000
BRENDA: Aquifex aeolicus
Textmining: Escherichia coli, Lepisosteidae
Yamaoka, T.; Yano, M.; Kondo, M.; Sasaki, H.; Hino, S.; Katashima, R.; Moritani, M.; Itakura, M.
Feedback inhibition of amidophosphoribosyltransferase regulates the rate of cell growth via purine nucleotide, DNA, and protein syntheses
J. Biol. Chem.
276
21285-21291
2001
BRENDA: Homo sapiens
Textmining: Cricetulus griseus, Mus musculus, Mus sp.
Eriksen, T.A.; Kadziola, A.; Larsen, S.
Binding of cations in Bacillus subtilis phosphoribosyldiphosphate synthetase and their role in catalysis
Protein Sci.
11
271-279
2002
Escherichia coli
Larsen, T.M.; Boehlein, S.K.; Schuster, S.M.; Richards, N.G.; Thoden, J.B.; Holden, H.M.; Rayment, I.
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product
Biochemistry
38
16146-16157
1999
Escherichia, Escherichia coli, Escherichia coli (P22106)
O'Donnell, A.F.; Tiong, S.; Nash, D.; Clark, D.V.
The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway
Genetics
154
1239-1253
2000
Diptera, vertebrata, Drosophila
Jimenez, A.; Santos, M.A.; Pompejus, M.; Revuelta, J.L.
Metabolic engineering of the purine pathway for riboflavin production in Ashbya gossypii
Appl. Environ. Microbiol.
71
5743-5751
2005
Eremothecium gossypii
Hwang, Y.; Ganguly, S.; Ho, A.K.; Klein, D.C.; Cole, P.A.
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug
Bioorg. Med. Chem.
15
2147-2155
2007
Homo sapiens
Browne, B.A.; Ramos, A.I.; Downs, D.M.
PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase
J. Bacteriol.
188
6786-6792
2006
Salmonella enterica
Koenigsknecht, M.J.; Ramos, I.; Downs, D.M.
Glutamine phosphoribosylpyrophosphate amidotransferase-independent phosphoribosyl amine synthesis from ribose 5-phosphate and glutamine or asparagine
J. Biol. Chem.
282
28379-28384
2007
BRENDA: no activity in Escherichia coli, no activity in Salmonella sp., no activity in Escherichia coli DM1293
Textmining: Bacteria, Escherichia coli
Patrick, W.M.; Matsumura, I.
A study in molecular contingency: glutamine phosphoribosylpyrophosphate amidotransferase is a promiscuous and evolvable phosphoribosylanthranilate isomerase
J. Mol. Biol.
377
323-336
2008
BRENDA: Escherichia coli K-12 (P0AG16)
Textmining: collection, Escherichia coli
Walsh, T.A.; Bauer, T.; Neal, R.; Merlo, A.O.; Schmitzer, P.R.; Hicks, G.R.; Honma, M.; Matsumura, W.; Wolff, K.; Davies, J.P.
Chemical genetic identification of glutamine phosphoribosylpyrophosphate amidotransferase as the target for a novel bleaching herbicide in Arabidopsis
Plant Physiol.
144
1292-1304
2007
BRENDA: Arabidopsis thaliana (Q9SI61), Arabidopsis thaliana (Q9STG9), Arabidopsis thaliana (Q9T0J5)
Textmining: Arabidopsis, plant, Escherichia coli
Wang, X.S.; Roitberg, A.E.; Richards, N.G.
Computational studies of ammonia channel function in glutamine 5-phosphoribosylpyrophosphate amidotransferase
Biochemistry
48
12272-12282
2009
Escherichia coli (P0AG16), Escherichia coli
Qin, L.; Gong, X.; Xie, J.; Jiang, D.; Cheng, J.; Li, G.; Huang, J.; Fu, Y.
Phosphoribosylamidotransferase, the first enzyme for purine de novo synthesis, is required for conidiation in the sclerotial mycoparasite Coniothyrium minitans
Fungal Genet. Biol.
48
956-965
2011
BRENDA: Paraphaeosphaeria minitans (F2XMV3), Paraphaeosphaeria minitans, Paraphaeosphaeria minitans ZS-1 (F2XMV3)
Textmining: Sclerotinia sclerotiorum, Sclerotia
Batool, S.; Nawaz, M.S.; Kamal, M.A.
In silico analysis of the amido phosphoribosyltransferase inhibition by PY873, PY899 and a derivative of isophthalic acid
Invest. New Drugs
31
1355-1363
2013
BRENDA: Homo sapiens (Q06203), Homo sapiens
Textmining: Bacillus subtilis
Goswami, M.; Chen, G.; Chakravarthi, B.; Pathi, S.; Anand, S.; Carskadon, S.; Giordano, T.; Chinnaiyan, A.; Thomas, D.; Palanisamy, N.; Beer, D.; Varambally, S.
Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer
Oncotarget
6
23445-23461
2015
Homo sapiens (Q06203)
Coleto, I.; Trenas, A.T.; Erban, A.; Kopka, J.; Alamillo, M.P.
Functional specialization of one copy of glutamine phosphoribosyl pyrophosphate amidotransferase in ureide production from symbiotically fixed nitrogen in Phaseolus vulgaris
Plant Cell Environ.
39
1767-1779
2016
Phaseolus vulgaris
Bibi, N.; Parveen, Z.; Nawaz, M.S.; Kamal, M.A.
In silico structure modeling and molecular docking analysis of phosphoribosyl pyrophosphate amidotransferase (PPAT) with antifolate inhibitors
Curr. Cancer Drug Targets
19
408-416
2019
Homo sapiens (Q06203), Homo sapiens
Cao, X.; Du, B.; Han, F.; Zhou, Y.; Ren, J.; Wang, W.; Chen, Z.; Zhang, Y.
Crystal structure of the chloroplastic glutamine phosphoribosylpyrophosphate amidotransferase GPRAT2 from Arabidopsis thaliana
Front. Plant Sci.
11
157
2020
Arabidopsis thaliana (Q9STG9), Arabidopsis thaliana
Iwahana, H; Honda, S; Tsujisawa, T; Takahashi, Y; Adzuma, K; Katashima, R; Yamaoka, T; Moritani, M; Yoshimoto, K; Itakura, M
Rat genomic structure of amidophosphoribosyltransferase, cDNA sequence of aminoimidazole ribonucleotide carboxylase, and cell cycle-dependent expression of these two physically linked genes.
Biochim Biophys Acta
1261
369-80
1995
Rattus, Gallus gallus, Homo sapiens
Zalkin, H; Argos, P; Narayana, SV; Tiedeman, AA; Smith, JM
Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase.
J Biol Chem
260
3350-4
1985
Escherichia coli, Homo sapiens
Woo, NS; Gordon, MJ; Graham, SR; Rossel, JB; Badger, MR; Pogson, BJ
A mutation in the purine biosynthetic enzyme ATASE2 impacts high light signalling and acclimation responses in green and chlorotic sectors of Arabidopsis leaves.
Funct Plant Biol
38
401-419
2011
Arabidopsis thaliana
Singer, SC; Holmes, EW
Human glutamine phosphoribosylpyrophosphate amidotransferase. Hysteretic properties.
J Biol Chem
252
7959-63
1977
Homo sapiens
Meyer, E; Switzer, RL
Regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase activity by end products.
J Biol Chem
254
5397-402
1979
Bacillus subtilis
Allsop, J; Watts, RW
Phosphoribosylpyrophosphate (PRPP) amidotransferase (EC 2.4.2.14) activity in unstimulated and stimulated human lymphocytes.
Adv Exp Med Biol
76A
434-40
1977
Homo sapiens
Kovarsky, J; Evans, MC; Holmes, EW
Regulation of human amidophosphoribosyltransferase: interaction of orthophosphate, PP-ribose-P, and purine ribonucleotides.
Can J Biochem
56
334-8
1978
Homo sapiens
Yen, RC; Becker, MA
Methylmercaptopurine ribonucleoside toxicity in human fibroblasts: inhibition of phosphoribosylpyrophosphate synthetase as well as amidophosphoribosyltransferase.
Adv Exp Med Biol
122B
137-43
1979
Homo sapiens
Wong, JY; Meyer, E; Switzer, RL
Glutamine phosphoribosylpyrophosphate amidotransferase from Bacillus subtilis. A novel iron-sulfur protein.
J Biol Chem
252
7424-6
1977
Bacillus subtilis, Bacillus
Itakura, M; Holmes, EW
Human amidophosphoribosyltransferase. An oxygen-sensitive iron-sulfur protein.
J Biol Chem
254
333-8
1979
Homo sapiens, Lethrinidae
Turnbough, CL; Switzer, RL
Oxygen-dependent inactivation of glutamine phosphoribosylpyrophosphate amidotransferase in stationary-phase cultures of Bacillus subtilis.
J Bacteriol
121
108-14
1975
Bacillus subtilis
Barton, JW; Bleskan, J; Patterson, D
Isolation of a human cDNA encoding amidophosphoribosyltransferase and functional complementation of a CHO Ade-A mutant deficient in this activity.
Somat Cell Mol Genet
17
311-22
1991
Homo sapiens, insertion sequences, Saccharomyces cerevisiae, Cricetulus griseus
Itakura, M; Tsuchiya, M; Yamashita, K
Increase of amidophosphoribosyltransferase activity and phosphoribosylpyrophosphate concentration as the basis for increased de novo purine biosynthesis in the regenerating rat liver.
Adv Exp Med Biol
195 Pt B
347-55
1986
Rattus
Itakura, M; Yamaoka, T; Yoshikawa, H; Yamashita, K
Paradoxical effects of glucagon on de novo purine synthesis in rat liver: in vitro phosphorylation of amidophosphoribosyltransferase.
Adv Exp Med Biol
253B
29-35
1989
Rattus
Grandoni, JA; Switzer, RL; Makaroff, CA; Zalkin, H
Evidence that the iron-sulfur cluster of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase determines stability of the enzyme to degradation in vivo.
J Biol Chem
264
6058-64
1989
Bacillus subtilis, Escherichia coli
Yamaoka, T; Kagita, F; Yoshikawa, H; Itakura, M; Yamashita, K
Purification of rat liver amidophosphoribosyltransferase.
Adv Exp Med Biol
253B
21-8
1989
Rattus
Itakura, M; Yamaoka, T; Yoshikawa, H; Yamashita, K; Sabina, R; Zalkin, H; Holmes, E
Controllable expression of an E. coli amidophosphoribosyltransferase (ATase) gene in ATase-deficient mammalian fibroblasts--a basic model for gene therapy.
Adv Exp Med Biol
253A
531-6
1989
Escherichia coli
Sampei, G; Mizobuchi, K
Nucleotide sequence of the Escherichia coli purF gene encoding amidophosphoribosyltransferase for de novo purine nucleotide synthesis.
Nucleic Acids Res
16
8717
1988
Escherichia coli
Makaroff, CA; Paluh, JL; Zalkin, H
Mutagenesis of ligands to the [4 Fe-4S] center of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase.
J Biol Chem
261
11416-23
1986
Bacillus subtilis
Marcolongo, R; Pompucci, G; Micheli, V; Marinello, E
[Behavior of glutamine phosphoribosyl pyrophosphate amidotransferase in patients with primary gout]
Reumatismo
26
223-9
0
Homo sapiens
Holmes, EW; Wyngaarden, JB; Kelley, WN
Human glutamine phosphoribosylpyrophosphate amidotransferase. Two molecular forms interconvertible by purine ribonucleotides and phosphoribosylpyrophosphate.
J Biol Chem
248
6035-40
1973
Homo sapiens
Reem, GH; Friend, C
Properties of 5'-phosphoribosylpyrophosphate amidotransferase in virus induced murine leukemia.
Biochim Biophys Acta
171
58-66
1969
Mus musculus
Reem, GH; Friend, C
Phosphoribosylamidotransferase: regulation of activity in virus-induced murine leukemia by purine nucleotides.
Science
157
1203-4
1967
Mus musculus
Allsop, J; Watts, RW
Activities of amidophosphoribosyltransferase (EC2.4.2.14) and the purine phosphoribosyltransferases (EC2.4.2.7 and 2.4.2.8), and the phosphoribosylpyrophosphate content of rat central nervous system at different stages of development--their possible relationship to the neurological dysfunction in the Lesch-Nyhan syndrome.
J Neurol Sci
46
221-32
1980
Homo sapiens, Metazoa, Rattus
Tso, JY; Zalkin, H; van Cleemput, M; Yanofsky, C; Smith, JM
Nucleotide sequence of Escherichia coli purF and deduced amino acid sequence of glutamine phosphoribosylpyrophosphate amidotransferase.
J Biol Chem
257
3525-31
1982
Escherichia coli
Vollmer, SJ; Switzer, RL; Debrunner, PG
Oxidation-reduction properties of the iron-sulfur cluster in Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase.
J Biol Chem
258
14284-93
1983
Bacillus subtilis, Electron
Nieto, DJ; Woods, RA
Studies on mutants affecting amidophosphoribosyltransferase activity in Saccharomyces cerevisiae.
Can J Microbiol
29
681-8
1983
Saccharomyces cerevisiae
Bernlohr, DA; Switzer, RL
Regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase inactivation in vivo.
J Bacteriol
153
937-49
1983
Bacillus subtilis
Ruppen, ME; Switzer, RL
Degradation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase in vivo.
J Biol Chem
258
2843-51
1983
Bacillus subtilis
Ruppen, ME; Switzer, RL
Involvement of the stringent response in degradation of glutamine phosphoribosylpyrophosphate amidotransferase in Bacillus subtilis.
J Bacteriol
155
56-63
1983
Bacillus subtilis
Vollmer, SJ; Switzer, RL; Hermodson, MA; Bower, SG; Zalkin, H
The glutamine-utilizing site of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase.
J Biol Chem
258
10582-5
1983
Bacillus subtilis, Escherichia coli
Makaroff, CA; Zalkin, H; Switzer, RL; Vollmer, SJ
Cloning of the Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase gene in Escherichia coli. Nucleotide sequence determination and properties of the plasmid-encoded enzyme.
J Biol Chem
258
10586-93
1983
Escherichia coli, Bacillus subtilis
Averill, BA; Dwivedi, A; Debrunner, P; Vollmer, SJ; Wong, JY; Switzer, RL
Evidence for a tetranuclear iron-sulfur center in glutamine phosphoribosylpyrophosphate amidotransferase from Bacillus subtilis.
J Biol Chem
255
6007-10
1980
Bacillus subtilis
Prajda, N; Donohue, JP; Weber, G
Increased amidophosphoribosyltransferase and decreased xanthine oxidase activity in human and rat renal cell carcinoma.
Life Sci
29
853-60
1981
Homo sapiens, Rattus
Tso, JY; Hermodson, MA; Zalkin, H
Glutamine phosphoribosylpyrophosphate amidotransferase from cloned Escherichia coli purF. NH2-terminal amino acid sequence, identification of the glutamine site, and trace metal analysis.
J Biol Chem
257
3532-6
1982
Escherichia coli
Gorai, I; Itoh, R; Usami, C; Tsushima, K
Properties of a chicken liver amidophosphoribosyltransferase preparation sensitive to inhibition by nucleotides.
Int J Biochem
13
91-7
1981
Gallus gallus
Allsop, J; Watts, RW
Activities of amidophosphoribosyltransferase and purine phosphoribosyltransferases in developing rat brain.
Adv Exp Med Biol
122A
361-6
1980
Rattus
Schoettle, SL; Christopherson, RI
Inhibition of murine amido phosphoribosyltransferase by folate derivatives.
Adv Exp Med Biol
370
151-4
1994
Mus musculus
Kim, JH; Delauney, AJ; Verma, DP
Control of de novo purine biosynthesis genes in ureide-producing legumes: induction of glutamine phosphoribosylpyrophosphate amidotransferase gene and characterization of its cDNA from soybean and Vigna.
Plant J
7
77-86
1995
Bacillus subtilis, Bacteria, Escherichia coli, Gallus gallus, Glycine max, Homo sapiens, Rattus, Saccharomyces cerevisiae, Vigna
Ito, T; Shiraishi, H; Okada, K; Shimura, Y
Two amidophosphoribosyltransferase genes of Arabidopsis thaliana expressed in different organs.
Plant Mol Biol
26
529-33
1994
Arabidopsis thaliana, plant
Iwahana, H; Oka, J; Mizusawa, N; Kudo, E; Ii, S; Yoshimoto, K; Holmes, EW; Itakura, M
Molecular cloning of human amidophosphoribosyltransferase.
Biochem Biophys Res Commun
190
192-200
1993
Homo sapiens, Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Gallus gallus, Rattus
Yamaoka, T; Yamashita, K; Itakura, M
Determination of the number and relative molecular mass of subunits in an oligomeric protein by two-dimensional electrophoresis. Application to the subunit structure analysis of rat liver amidophosphoribosyltransferase.
J Chromatogr
630
345-51
1993
Rattus
Iwahana, H; Yamaoka, T; Mizutani, M; Mizusawa, N; Ii, S; Yoshimoto, K; Itakura, M
Molecular cloning of rat amidophosphoribosyltransferase.
J Biol Chem
268
7225-37
1993
Rattus, Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Gallus gallus
Li, S; Smith, JL; Zalkin, H
Mutational analysis of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase propeptide processing.
J Bacteriol
181
1403-8
1999
Bacillus subtilis
Chen, S; Burgner, JW; Krahn, JM; Smith, JL; Zalkin, H
Tryptophan fluorescence monitors multiple conformational changes required for glutamine phosphoribosylpyrophosphate amidotransferase interdomain signaling and catalysis.
Biochemistry
38
11659-69
1999
Varanidae
Woods, RA; Roberts, DG; Stein, DS; Filpula, D
Adenine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.
J Gen Microbiol
130
2629-37
1984
Saccharomyces cerevisiae
Woods, RA; Roberts, DG; Friedman, T; Jolly, D; Filpula, D
Hypoxanthine: guanine phosphoribosyltransferase mutants in Saccharomyces cerevisiae.
Mol Gen Genet
191
407-12
1983
Saccharomyces cerevisiae
Bussey, LB; Switzer, RL
The degA gene product accelerates degradation of Bacillus subtilis phosphoribosylpyrophosphate amidotransferase in Escherichia coli.
J Bacteriol
175
6348-53
1993
Escherichia coli, Bacillus subtilis
Boland, MJ; Hanks, JF; Reynolds, PH; Blevins, DG; Tolbert, NE; Schubert, KR
Subcellular organization of ureide biogenesis from glycolytic intermediates and ammonium in nitrogen-fixing soybean nodules.
Planta
155
45-51
1982
Glycine max, Electron
Palmer, DK; Jones, C
Gene mapping in chicken-Chinese hamster somatic cell hybrids. Serum albumin and phosphoglucomutase-2 structural genes on chicken chromosome 6.
J Hered
77
106-8
0
Gallus gallus, Homo sapiens, Mus sp., Mammalia
Natsumeda, Y; Lui, MS; Emrani, J; Faderan, MA; Reardon, MA; Eble, JN; Glover, JL; Weber, G
Purine enzymology of human colon carcinomas.
Cancer Res
45
2556-9
1985
Homo sapiens
Taylor, MW; Olivelle, S; Levine, RA; Coy, K; Hershey, H; Gupta, KC; Zawistowich, L
Regulation of de novo purine biosynthesis in Chinese hamster cells.
J Biol Chem
257
377-80
1982
Cricetulus griseus
Boss, GR
Decreased phosphoribosylpyrophosphate as the basis for decreased purine synthesis during amino acid starvation of human lymphoblasts.
J Biol Chem
259
2936-41
1984
Homo sapiens
Walker, JE; Gay, NJ; Saraste, M; Eberle, AN
DNA sequence around the Escherichia coli unc operon. Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS.
Biochem J
224
799-815
1984
Escherichia coli, Terminalia elliptica
Burkin, DJ; Morse, HG; Broad, TE; Pearce, PD; Ansari, HA; Lewis, PE; Jones, C
Mapping the sheep genome: production of characterized sheep x hamster cell hybrids.
Genomics
16
466-72
1993
Ovis aries, Homo sapiens
Feldman, RI; Taylor, MW
Purine mutants of mammalian cell lines. II. Identification of a phosphoribosylpyrophosphate amidotransferase-deficient mutant of Chinese hamster lung cells.
Biochem Genet
13
227-34
1975
Cricetulus griseus
Mäntsälä, P; Zalkin, H
Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase.
J Biol Chem
259
8478-84
1984
Saccharomyces cerevisiae, Escherichia coli, Bacillus subtilis
Yang, LT; Zhou, YF; Wang, YY; Wu, YM; Qian, B; Wang, H; Chen, LS
Phosphorus-mediated alleviation of aluminum toxicity revealed by the iTRAQ technique in Citrus grandis roots.
PLoS One
14
e0223516
2019
Citrus
Fedorovych, DV; Dmytruk, KV; Sibirny, AA
Recent Advances in Construction of the Efficient Producers of Riboflavin and Flavin Nucleotides (FMN, FAD) in the Yeast Candida famata.
Methods Mol Biol
2280
15-30
2021
Saccharomyces cerevisiae, Debaryomyces hansenii
Brayton, KA; Chen, Z; Zhou, G; Nagy, PL; Gavalas, A; Trent, JM; Deaven, LL; Dixon, JE; Zalkin, H
Two genes for de novo purine nucleotide synthesis on human chromosome 4 are closely linked and divergently transcribed.
J Biol Chem
269
5313-21
1994
Homo sapiens, Cricetulus griseus
Tsuchiya, M; Yoshikawa, H; Itakura, M; Yamashita, K
Increased de novo purine synthesis by insulin through selective enzyme induction in primary cultured rat hepatocytes.
Am J Physiol
258
C841-8
1990
Rattus
Itakura, M; Maeda, N; Yamashita, K
Increased rate of purine biosynthesis in rat liver after bilateral adrenalectomy.
Am J Physiol
251
E373-8
1986
Rattus
Itakura, M; Maeda, N; Tsuchiya, M; Yamashita, K
Increased rate of de novo purine synthesis and its mechanism in regenerating rat liver.
Am J Physiol
251
G585-90
1986
Rattus
Peltonen, T; Mäntsälä, P
Isolation and characterization of a purC(orf)QLF operon from Lactococcus [correction of Lactobacillus] lactis MG1614.
Mol Gen Genet
261
31-41
1999
Escherichia coli, Lactococcus lactis, Lactococcus
Hung, WF; Chen, LJ; Boldt, R; Sun, CW; Li, HM
Characterization of Arabidopsis glutamine phosphoribosyl pyrophosphate amidotransferase-deficient mutants.
Plant Physiol
135
1314-23
2004
Arabidopsis, insertion sequences, plant
Smolina, VS; Andrianova, VM; Bekker, ML
[Regulation of purine nucleotide biosynthesis in mutant Saccharomyces cerevisiae yeasts with increased sensitivity of the pathway for de novo synthesis to inhibition by exogenous guanine]
Genetika
14
1495-1502
1978
Saccharomyces cerevisiae, yeasts
Brown, EG; Evans, CH
Effects of benzimidazole on the purine and pyrimidine metabolism of yeast.
Biochim Biophys Acta
582
458-69
1979
Saccharomyces cerevisiae
Becher, H; Mack, T; Gerok, W
[Purine nucleotide synthesis in human liver an its influence by benzbromarone (author's transl)]
Klin Wochenschr
56
835-7
1978
Homo sapiens
Itakura, M; Maeda, N; Yamashita, K
Mechanism of increased rate of de novo purine biosynthesis in rat liver after bilateral adrenalectomy.
Adv Exp Med Biol
195 Pt B
337-45
1986
Rattus, Metazoa
Tsuchiya, M; Itakura, M; Yamashita, K
The mechanism of insulin-induced increase of the rate of de novo purine biosynthesis in primary cultured rat hepatocytes.
Adv Exp Med Biol
195 Pt B
623-31
1986
Rattus
Itakura, M; Maeda, N; Tsuchiya, M; Yamashita, K
Glucagon infusion increases rate of purine synthesis de novo in rat liver.
Am J Physiol
253
E684-90
1987
Rattus, Metazoa
Beardsley, S; Kunjara, S; Greenbaum, AL
Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes.
Biochem J
250
395-9
1988
Rattus
McCairns, E; Fahey, D; Sauer, D; Rowe, PB
De novo purine synthesis in human lymphocytes. Partial co-purification of the enzymes and some properties of the pathway.
J Biol Chem
258
1851-6
1983
Homo sapiens
Smith, JM; Gots, JS
purF-lac fusion and direction of purF transcription in Escherichia coli.
J Bacteriol
143
1156-64
1980
Escherichia coli, Escherichia coli K-12
Smolina, VS; Bekker, ML
[Properties of 5-phosphoryl-1-pyrophosphate amidotransferase from the yeast Saccharomyces cerevisiae wild type and mutant with altered purine biosynthesis regulation]
Biokhimiia
47
162-7
1982
Saccharomyces cerevisiae
Ludin, KM; Hilti, N; Schweingruber, ME
The ade4 gene of Schizosaccharomyces pombe: cloning, sequence and regulation.
Curr Genet
25
465-8
1994
Schizosaccharomyces pombe, Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Gallus gallus, Homo sapiens, Rattus
Clark, DV
Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis.
Genetics
136
547-57
1994
Drosophila, Bacteria, Bacillus subtilis, Saccharomyces cerevisiae, vertebrata
Shi, RZ; Lyons, SD; Christopherson, RI
Metabolic effects of thiopurine derivatives against human CCRF-CEM leukaemia cells.
Int J Biochem Cell Biol
30
885-95
1998
Homo sapiens
Fairbanks, LD; Rückemann, K; Qiu, Y; Hawrylowicz, CM; Richards, DF; Swaminathan, R; Kirschbaum, B; Simmonds, HA
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
Biochem J
342 ( Pt 1)
143-52
1999
Homo sapiens
Clark, DV; MacAfee, N
The purine biosynthesis enzyme PRAT detected in proenzyme and mature forms during development of Drosophila melanogaster.
Insect Biochem Mol Biol
30
315-23
2000
Drosophila, Drosophila melanogaster
Malmanche, N; Drapeau, D; Cafferty, P; Ji, Y; Clark, DV
The PRAT purine synthesis gene duplication in Drosophila melanogaster and Drosophila virilis is associated with a retrotransposition event and diversification of expression patterns.
J Mol Evol
56
630-42
2003
Drosophila melanogaster, Drosophila virilis, Drosophila
Malmanche, N; Clark, DV
Identification of trans-dominant modifiers of Prat expression in Drosophila melanogaster.
Genetics
164
1419-33
2003
Drosophila melanogaster
Kamal, MA; Christopherson, RI
Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates.
Int J Biochem Cell Biol
36
545-51
2004
Homo sapiens
Malmanche, N; Clark, DV
Drosophila melanogaster Prat, a purine de novo synthesis gene, has a pleiotropic maternal-effect phenotype.
Genetics
168
2011-23
2004
Drosophila melanogaster
Ji, Y; Clark, DV
The purine synthesis gene Prat2 is required for Drosophila metamorphosis, as revealed by inverted-repeat-mediated RNA interference.
Genetics
172
1621-31
2006
Drosophila, Bacteria, eukaryota, Drosophila melanogaster
Hackett, JM; Clark, DV
Modifiers of Prat, a de novo purine synthesis gene, in Drosophila melanogaster.
Genome
52
957-67
2009
Drosophila melanogaster
Merzetti, E; Hackett, JM; Clark, DV
Transcriptional regulation of the purine de novo synthesis gene Prat in Drosophila melanogaster.
Gene
518
280-6
2013
Drosophila melanogaster
Niu, Y; Zhou, Y; Lin, H; Gao, LH; Xiong, W; Zhu, H; Zou, CG; Li, L
Inhibition of 3,5,2',4'-Tetrahydroxychalcone on Production of Uric Acid in Hypoxanthine-Induced Hyperuricemic Mice.
Biol Pharm Bull
41
99-105
2018
Mus sp.
Denton, JE; Lui, MS; Aoki, T; Sebolt, J; Weber, G
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
Life Sci
30
1073-80
1982
Rattus
Mäntsälä, P; Zalkin, H
Glutamine amidotransferase function. Replacement of the active-site cysteine in glutamine phosphoribosylpyrophosphate amidotransferase by site-directed mutagenesis.
J Biol Chem
259
14230-6
1984
Bacillus subtilis
Martelli, A; Wattenhofer-Donzé, M; Schmucker, S; Bouvet, S; Reutenauer, L; Puccio, H
Frataxin is essential for extramitochondrial Fe S cluster proteins in mammalian tissues.
Hum Mol Genet
16
2651-8
2007
Mus musculus
Hahn, R; Oberrauch, W; Mecke, D
Activation of glutaminase by phosphoribosyl-pyrophosphate and its interference with the assay of phosphoribosylpyrophosphate amidotransferase.
Biochim Biophys Acta
566
152-6
1979
Rattus
Turnbough, CL; Switzer, RL
Oxygen-dependent inactivation of glutamine phosphoribosylpyrophosphate amidotransferase in vitro inactivation.
J Bacteriol
121
115-20
1975
Bacillus subtilis
Zhou, G; Broyles, SS; Dixon, JE; Zalkin, H
Avian glutamine phosphoribosylpyrophosphate amidotransferase propeptide processing and activity are dependent upon essential cysteine residues.
J Biol Chem
267
7936-42
1992
Bacillus subtilis, Gallus gallus
Sant, ME; Lyons, SD; Phillips, L; Christopherson, RI
Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells.
J Biol Chem
267
11038-45
1992
Mus musculus
Zhou, GC; Dixon, JE; Zalkin, H
Cloning and expression of avian glutamine phosphoribosylpyrophosphate amidotransferase. Conservation of a bacterial propeptide sequence supports a role for posttranslational processing.
J Biol Chem
265
21152-9
1990
animal, Bacteria, Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Cricetulus griseus
Mei, BG; Zalkin, H
Amino-terminal deletions define a glutamine amide transfer domain in glutamine phosphoribosylpyrophosphate amidotransferase and other PurF-type amidotransferases.
J Bacteriol
172
3512-4
1990
Escherichia coli
Itakura, M; Tsuchiya, M; Yamashita, K; Oda, T
Malotilate (diisopropyl 1,3-dithiol-2-ylidenemalonate) increases liver de novo purine synthesis and amidophosphoribosyltransferase activity.
J Pharmacol Exp Ther
237
794-8
1986
Rattus
Souciet, JL; Hermodson, MA; Zalkin, H
Mutational analysis of the glutamine phosphoribosylpyrophosphate amidotransferase pro-peptide.
J Biol Chem
263
3323-7
1988
Bacillus subtilis, insertion sequences
Boss, GR; Idriss, SD; Willis, RC; Seegmiller, JE
Assay of glutamine phosphoribosylpyrophosphate amidotransferase using [1-14C]phosphoribosylpyrophosphate.
Anal Biochem
130
283-6
1983
Homo sapiens
Leff, RL; Itakura, M; Udom, A; Holmes, EW
A possible role for oxygen inactivation in the regulation of amidophosphoribosyltransferase activity in mammalian cells.
Adv Enzyme Regul
22
403-11
1984
Bacillus subtilis, Homo sapiens, Cricetulus griseus
Yamaoka, T; Kondo, M; Honda, S; Iwahana, H; Moritani, M; Ii, S; Yoshimoto, K; Itakura, M
Amidophosphoribosyltransferase limits the rate of cell growth-linked de novo purine biosynthesis in the presence of constant capacity of salvage purine biosynthesis.
J Biol Chem
272
17719-25
1997
Homo sapiens, Cricetulus griseus, Rattus, animal
Chen, S; Zheng, L; Dean, DR; Zalkin, H
Role of NifS in maturation of glutamine phosphoribosylpyrophosphate amidotransferase.
J Bacteriol
179
7587-90
1997
Bacillus subtilis, Azotobacter vinelandii, Escherichia coli
Raushel, FM; Thoden, JB; Holden, HM
The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.
Biochemistry
38
7891-9
1999
Escherichia coli
Gassmann, MG; Stanzel, A; Werner, S
Growth factor-regulated expression of enzymes involved in nucleotide biosynthesis: a novel mechanism of growth factor action.
Oncogene
18
6667-76
1999
Homo sapiens
Moore, EC; Hurlbert, RB; Boss, GR; Massia, SP
Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P).
Biochem Pharmacol
38
4045-51
1989
Homo sapiens
Jayaram, HN; Lui, MS; Plowman, J; Pillwein, K; Reardon, MA; Elliott, WL; Weber, G
Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride.
Cancer Chemother Pharmacol
26
88-92
1990
Rattus
Iwahana, H; Itakura, M
[Amidophosphoribosyltransferase]
Nippon Rinsho
54
3202-6
1996
Bacillus subtilis, Gallus gallus, Homo sapiens, Rattus
Reem, GH
Purine biosynthesis in mutant mammalian cells.
Ciba Found Symp
105-26
1977
Homo sapiens, Mus musculus
Itakura, M; Sabina, RL; Heald, PW; Holmes, EW
Basis for the control of purine biosynthesis by purine ribonucleotides.
J Clin Invest
67
994-1002
1981
Metazoa, Homo sapiens, Mus sp., animal
Natsumeda, Y; Prajda, N; Donohue, JP; Glover, JL; Weber, G
Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues.
Cancer Res
44
2475-9
1984
Homo sapiens, Rattus, Transformation, Mus musculus
Iwahana, H; Mizusawa, N; Ii, S; Yoshimoto, K; Itakura, M
An end-trimming method to amplify adjacent cDNA fragments by PCR.
Biotechniques
16
94-8
1994
Rattus
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