Reference on EC 2.1.1.360 - [histone H3]-lysine79 N-trimethyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shanower, G.A.; Muller, M.; Blanton, J.L.; Honti, V.; Gyurkovics, H.; Schedl, P.
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase
Genetics
169
173-184
2005
Drosophila melanogaster
Zhang, W.; Xia, X.; Jalal, D.I.; Kuncewicz, T.; Xu, W.; Lesage, G.D.; Kone, B.C.
Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase
Am. J. Physiol. Cell Physiol.
290
C936-C946
2006
Homo sapiens, Mus musculus
Lazzaro, F.; Sapountzi, V.; Granata, M.; Pellicioli, A.; Vaze, M.; Haber, J.E.; Plevani, P.; Lydall, D.; Muzi-Falconi, M.
Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres
EMBO J.
27
1502-1512
2008
Saccharomyces cerevisiae
Conde, F.; Refolio, E.; Cordon-Preciado, V.; Cortes-Ledesma, F.; Aragon, L.; Aguilera, A.; San-Segundo, P.A.
The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae
Genetics
182
437-446
2009
Saccharomyces cerevisiae
List, O.; Togawa, T.; Tsuda, M.; Matsuo, T.; Elard, L.; Aigaki, T.
Overexpression of grappa encoding a histone methyltransferase enhances stress resistance in Drosophila
Hereditas
146
19-28
2009
Drosophila melanogaster
Figueiredo, L.M.; Janzen, C.J.; Cross, G.A.
A histone methyltransferase modulates antigenic variation in African trypanosomes
PLoS Biol.
6
e161
2008
Trypanosoma brucei, Trypanosoma brucei Lister 427
Tatum, D.; Li, S.
Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79
J. Biol. Chem.
286
17530-17535
2011
Saccharomyces cerevisiae
Wood, K.; Tellier, M.; Murphy, S.
DOT1L and H3K79 methylation in transcription and genomic stability
Biomolecules
8
E11
2018
Homo sapiens (Q8TEK3)
Wong, M.; Tee, A.E.L.; Milazzo, G.; Bell, J.L.; Poulos, R.C.; Atmadibrata, B.; Sun, Y.; Jing, D.; Ho, N.; Ling, D.; Liu, P.Y.; Zhang, X.D.; Huettelmaier, S.; Wong, J.W.H.; Wang, J.; Polly, P.; Perini, G.; Scarlett, C.J.; Liu, T.
The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription
Cancer Res.
77
2522-2533
2017
Homo sapiens (Q8TEK3)
Cattaneo, P.; Kunderfranco, P.; Greco, C.; Guffanti, A.; Stirparo, G.G.; Rusconi, F.; Rizzi, R.; Di Pasquale, E.; Locatelli, S.L.; Latronico, M.V.; Bearzi, C.; Papait, R.; Condorelli, G.
DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation
Cell Death Differ.
23
555-564
2016
Mus musculus
Gao, Y.; Ge, W.
The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis
Cell Death Dis.
9
33
2018
Mus musculus
Kuntimaddi, A.; Achille, N.J.; Thorpe, J.; Lokken, A.A.; Singh, R.; Hemenway, C.S.; Adli, M.; Zeleznik-Le, N.J.; Bushweller, J.H.
Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 di- and tri-methylation on target genes and transformation potential
Cell Rep.
11
808-820
2015
Homo sapiens (Q8TEK3), Homo sapiens
Kari, V.; Raul, S.K.; Henck, J.M.; Kitz, J.; Kramer, F.; Kosinsky, R.L.; Uebelmesser, N.; Mansour, W.Y.; Eggert, J.; Spitzner, M.; Najafova, Z.; Bastians, H.; Grade, M.; Gaedcke, J.; Wegwitz, F.; Johnsen, S.A.
The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
Clin. Epigenetics
11
4-4
2019
Homo sapiens (Q8TEK3)
Evanno, E.; Godet, J.; Piccirilli, N.; Guilhot, J.; Milin, S.; Gombert, J.; Fouchaq, B.; Roche, J.
Tri-methylation of H3K79 is decreased in TGF-beta1-induced epithelial-to-mesenchymal transition in lung cancer
Clin. Epigenetics
9
80
2017
Homo sapiens (Q8TEK3)
Wen, L.; Fu, L.; Guo, X.; Chen, Y.; Shi, Y.B.
Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis
FASEB J.
29
385-393
2015
Xenopus tropicalis
Jang, S.; Kang, C.; Yang, H.S.; Jung, T.; Hebert, H.; Chung, K.Y.; Kim, S.J.; Hohng, S.; Song, J.J.
Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase
Genes Dev.
33
620-625
2019
Homo sapiens (Q8TEK3)
Li, T.; Liu, Q.; Garza, N.; Kornblau, S.; Jin, V.
Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing
Genome Med.
10
30
2018
Homo sapiens (Q8TEK3)
Valencia-Sanchez, M.I.; De Ioannes, P.; Wang, M.; Vasilyev, N.; Chen, R.; Nudler, E.; Armache, J.P.; Armache, K.J.
Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination
Mol. Cell
74
1010-1019
2019
Homo sapiens (Q8TEK3)
Farooq, Z.; Banday, S.; Pandita, T.; Altaf, M.
The many faces of histone H3K79 methylation
Mutat. Res. Rev. Mutat. Res.
768
46-52
2016
Saccharomyces cerevisiae (Q04089), Homo sapiens (Q8TEK3)
Liu, D.; Zhang, X.X.; Li, M.C.; Cao, C.H.; Wan, D.Y.; Xi, B.X.; Tan, J.H.; Wang, J.; Yang, Z.Y.; Feng, X.X.; Ye, F.; Chen, G.; Wu, P.; Xi, L.; Wang, H.; Zhou, J.F.; Feng, Z.H.; Ma, D.; Gao, Q.L.
C/EBPbeta enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
Nat. Commun.
9
1739
2018
Homo sapiens (Q8TEK3)
Ogoh, H.; Yamagata, K.; Nakao, T.; Sandell, L.; Yamamoto, A.; Yamashita, A.; Tanga, N.; Suzuki, M.; Abe, T.; Kitabayashi, I.; Watanabe, T.; Sakai, D.
Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development
Sci. Rep.
7
11922
2017
Mus musculus
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