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Disease on EC 2.1.1.360 - [histone H3]-lysine79 N-trimethyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Arthritis
Arthritis mutilans.
Arthritis mutilans: a report from the GRAPPA 2012 annual meeting.
Composite Measures of Disease Activity in Psoriatic Arthritis: Comparative Instrument Performance Based on the Efficacy of Guselkumab in an Interventional Phase 2 Trial.
Development of criteria to distinguish inflammatory from noninflammatory arthritis, enthesitis, dactylitis, and spondylitis: a report from the GRAPPA 2013 Annual Meeting.
Development of simple clinical criteria for the definition of inflammatory arthritis, enthesitis, dactylitis, and spondylitis: a report from the GRAPPA 2012 annual meeting.
Distinguishing inflammatory from noninflammatory arthritis, enthesitis, and dactylitis in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review.
GRAPPA 2013 Annual Meeting, rheumatology updates: psoriatic arthritis (PsA) biomarker project, arthritis mutilans, PsA-peripheral spondyloarthritis epidemiology project.
Hypothesis-free analyses from a large psoriatic arthritis cohort support merger to consolidated peripheral arthritis definition without subtyping.
Prologue: 2012 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2013 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
The need to define musculoskeletal inflammation: a report from the GRAPPA 2010 annual meeting.
Arthritis, Juvenile
Juvenile Psoriatic Arthritis: A Report from the GRAPPA 2017 Annual Meeting.
Arthritis, Psoriatic
Application of the GRAPPA Psoriatic Arthritis Treatment Recommendations in Clinical Practice.
Benchmarking Care in Psoriatic Arthritis - The QUANTUM Report: A Report from the GRAPPA 2016 Annual Meeting.
Biomarkers in psoriasis and psoriatic arthritis: GRAPPA 2008.
Biomarkers of radiographic progression in psoriatic arthritis: a report from the GRAPPA 2011 annual meeting.
Bone formation in psoriatic arthritis: a report from the GRAPPA 2013 Annual Meeting.
Cardiovascular comorbidities in psoriasis and psoriatic arthritis: pathogenesis, consequences for patient management, and future research agenda: a report from the GRAPPA 2009 annual meeting.
Cardiovascular comorbidities of psoriasis and psoriatic arthritis: a report from the GRAPPA 2012 annual meeting.
Comorbidities of psoriatic arthritis -- metabolic syndrome and prevention: a report from the GRAPPA 2010 annual meeting.
Comparison of disease activity measures in early psoriatic arthritis in usual care.
Composite disease activity and responder indices for psoriatic arthritis: a report from the GRAPPA 2013 meeting on development of cutoffs for both disease activity states and response.
Composite Measures in Psoriatic Arthritis: a report from the GRAPPA 2009 annual meeting.
Composite measures in psoriatic arthritis: GRAPPA 2008.
Composite Measures of Disease Activity in Psoriatic Arthritis: Comparative Instrument Performance Based on the Efficacy of Guselkumab in an Interventional Phase 2 Trial.
Content and Face Validity and Feasibility of 5 Candidate Instruments for Psoriatic Arthritis Randomized Controlled Trials: The PsA OMERACT Core Set Workshop at the GRAPPA 2017 Annual Meeting.
Current challenges in the genetics of psoriatic arthritis: a report from the GRAPPA 2009 annual meeting.
Development and Validation of a Sonographic Enthesitis Instrument in Psoriatic Arthritis: The GRAPPA Diagnostic Ultrasound Enthesitis Tool (DUET) Project.
Development of a Preliminary Ultrasonographic Enthesitis Score in Psoriatic Arthritis - GRAPPA Ultrasound Working Group.
Development of composite measures for psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Distinguishing inflammatory from noninflammatory arthritis, enthesitis, and dactylitis in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review.
Exploring priority research areas in psoriasis and psoriatic arthritis from dermatologists' perspective: a report from the GRAPPA 2011 annual meeting.
Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Genetics of psoriasis and psoriatic arthritis: update and future direction.
Global partnering opportunities and challenges of psoriasis and psoriatic arthritis in Latin America: a report from the GRAPPA 2010 annual meeting.
GRAPPA 2007: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis.
GRAPPA 2013 Annual Meeting, rheumatology updates: psoriatic arthritis (PsA) biomarker project, arthritis mutilans, PsA-peripheral spondyloarthritis epidemiology project.
GRAPPA 2017 Project Report.
GRAPPA Responder Index Project (GRACE): a report from the GRAPPA 2011 annual meeting.
GRAPPA Trainees Symposium 2013: a report from the GRAPPA 2013 Annual Meeting.
GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting.
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis - GRAPPA (2003-2013).
Imaging in psoriasis and psoriatic arthritis: GRAPPA 2008.
Infectious, oncologic, and autoimmune comorbidities of psoriasis and psoriatic arthritis: a report from the GRAPPA 2012 annual meeting.
Inflammatory spinal disease in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Instruments Measuring Physical Function for Psoriatic Arthritis Endorsed at GRAPPA 2020 Annual Meeting: Updates of the GRAPPA-OMERACT Working Group.
International league of associations for rheumatology recommendations for the management of psoriatic arthritis in resource-poor settings.
Magnetic resonance imaging in psoriatic arthritis -- update on current status and future perspectives: a report from the GRAPPA 2010 annual meeting.
Magnetic Resonance Imaging of Axial and Peripheral Disease in Psoriatic Arthritis: A Report From the 2020 GRAPPA Annual Meeting.
Management of psoriatic arthritis in 2016: a comparison of EULAR and GRAPPA recommendations.
Nail Enthesis Ultrasound in Psoriasis and Psoriatic Arthritis: A Report from the 2016 GRAPPA Annual Meeting.
New GRAPPA and EULAR recommendations for the management of psoriatic arthritis: Process and challenges faced.
New GRAPPA recommendations for the management of psoriasis and psoriatic arthritis: process, challenges and implementation.
Outcomes of the 2019 GRAPPA Workshop on Continuous Composite Indices for the Assessment of Psoriatic Arthritis and Membership-recommended Next Steps.
Outcomes research in psoriasis and psoriatic arthritis using large databases and research networks: a report from the GRAPPA 2013 Annual Meeting.
Overview of the Grant Writing Workshop From the GRAPPA 2020 Annual Meeting.
Patient Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA and OMERACT Study.
Patient participation in psoriasis and psoriatic arthritis outcome research: a report from the GRAPPA 2013 Annual Meeting.
Peripheral spondyloarthritis and psoriatic arthritis; overlaps and distinctions: a report from the GRAPPA 2012 annual meeting.
Peripheral spondyloarthritis: Concept, diagnosis and treatment.
Physician's Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA Study.
Presidential Round Table: A Report from the GRAPPA Annual Meeting.
Proceedings of the GRAPPA 2016 Retreat.
Prologue: 2010 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2012 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2013 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2016 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2018 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2019 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Psoriasis and psoriatic arthritis educational initiatives: an update from the 2013 GRAPPA Annual Meeting.
Psoriasis and psoriatic arthritis in Peruvian aborigines: a report from the GRAPPA 2011 annual meeting.
Psoriasis and Psoriatic Arthritis in the Context of the COVID-19 Pandemic: A Plenary Session From the GRAPPA 2020 Annual Meeting.
Psoriasis and Psoriatic Arthritis Video Project 2010: a report from the GRAPPA annual meeting.
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting.
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting.
Psoriasis and psoriatic arthritis video project: an update from the GRAPPA 2011 annual meeting.
Psoriatic arthritis and psoriasis projects in Italy: a report from the GRAPPA 2011 annual meeting.
Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire and the role of dermatologists: a report from the GRAPPA 2009 annual meeting.
Radiographic progression is less in psoriatic arthritis achieving a good response to treatment: data using newer composite indices of disease activity.
Report of the GRAPPA-OMERACT Psoriatic Arthritis Working Group from the GRAPPA 2015 Annual Meeting.
Systematic review of treatments for psoriatic arthritis: 2014 update for the GRAPPA.
The Benefits and Challenges of Setting Up a Longitudinal Psoriatic Arthritis Database.
The GRAPPA-OMERACT Psoriatic Arthritis Working Group at the 2018 Annual Meeting: Report and Plan for Completing the Core Outcome Measurement Set.
The GRAPPA-OMERACT Working Group: 4 Prioritized Domains for Completing the Core Outcome Measurement Set for Psoriatic Arthritis 2019 Updates.
The Role of Ultrasound in Research and Clinical Practice in Psoriatic Arthritis: Highlights From the GRAPPA Ultrasound Workshop.
Toronto Psoriatic Arthritis Screening (ToPAS) questionnaire: a report from the GRAPPA 2009 annual meeting.
Treatment strategies for psoriatic arthritis.
Treatments for Psoriatic Arthritis, a Guide for Patients Written by Fellow Patients: A Report from the GRAPPA 2016 Annual Meeting.
Update on biomarkers in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Updates on Axial Psoriatic Arthritis From the 2020 GRAPPA Annual Meeting.
Validation of the Italian version of proposed GRAPPA flare questionnaire for patients with psoriatic arthritis.
Brain Injuries, Traumatic
Artifactual microhemorrhage generated by susceptibility weighted image processing.
Brain Neoplasms
Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T.
Breast Neoplasms
Alcohol consumption and risk of breast cancer: a multicentre Italian case-control study.
Cardiovascular Diseases
Epidemiology and potential pathomechanisms of cardiovascular comorbidities in psoriasis: a report from the GRAPPA 2010 annual meeting.
Chagas Disease
Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Colorectal Neoplasms
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.
COVID-19
GRAPPA Patient Research Partner Network: Update to the GRAPPA 2020 Annual Meeting.
Psoriasis and Psoriatic Arthritis in the Context of the COVID-19 Pandemic: A Plenary Session From the GRAPPA 2020 Annual Meeting.
Influenza, Human
Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response.
Intracranial Aneurysm
Highly accelerated intracranial 4D flow MRI: evaluation of healthy volunteers and patients with intracranial aneurysms.
Leukemia
Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.
Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.
DOT1L complex regulates transcriptional initiation in human erythroleukemic cells.
Identification of phenoxyacetamide derivatives as novel DOT1L inhibitors via docking screening and molecular dynamics simulation.
Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.
Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia.
Structural characteristics of coiled-coil regions in AF10-DOT1L and AF10-inhibitory peptide complex.
Leukemia, Myeloid, Acute
Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.
Metabolic Syndrome
Comorbidities of psoriatic arthritis -- metabolic syndrome and prevention: a report from the GRAPPA 2010 annual meeting.
Musculoskeletal Diseases
Prologue: 2010 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2011 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Myocardial Infarction
k-t-Space accelerated myocardial perfusion.
Neoplasms
Accelerated 3D bSSFP imaging for treatment planning on an MRI-guided radiotherapy system.
Depletion of H3K79 methyltransferase Dot1L promotes cell invasion and cancer stem-like cell property in ovarian cancer.
Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-? production by mediating H3K79me2/3 methylation in macrophages.
Ovarian Neoplasms
Depletion of H3K79 methyltransferase Dot1L promotes cell invasion and cancer stem-like cell property in ovarian cancer.
Disruptor of telomeric silencing 1-like promotes ovarian cancer tumor growth by stimulating pro-tumorigenic metabolic pathways and blocking apoptosis.
Psoriasis
Biomarkers for comorbidities in psoriasis: a report from the grappa 2011 annual meeting.
Biomarkers in psoriasis and psoriatic arthritis: GRAPPA 2008.
Cardiovascular comorbidities in psoriasis and psoriatic arthritis: pathogenesis, consequences for patient management, and future research agenda: a report from the GRAPPA 2009 annual meeting.
Cardiovascular comorbidities of psoriasis and psoriatic arthritis: a report from the GRAPPA 2012 annual meeting.
Comorbidities of psoriatic arthritis -- metabolic syndrome and prevention: a report from the GRAPPA 2010 annual meeting.
Composite Measures in Psoriatic Arthritis: a report from the GRAPPA 2009 annual meeting.
Composite measures in psoriatic arthritis: GRAPPA 2008.
Comprehensive Assessment of the Psoriasis Patient (CAPP): A Report from the GRAPPA 2015 Annual Meeting.
Current and relevant concepts in psoriatic arthritis.
Defining Low Disease Activity States in Psoriatic Arthritis using Novel Composite Disease Instruments.
Defining Outcome Measures for Psoriasis: The IDEOM Report from the GRAPPA 2016 Annual Meeting.
Development of composite measures for psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review.
Epidemiology and potential pathomechanisms of cardiovascular comorbidities in psoriasis: a report from the GRAPPA 2010 annual meeting.
Exploring priority research areas in psoriasis and psoriatic arthritis from dermatologists' perspective: a report from the GRAPPA 2011 annual meeting.
Genetics of psoriasis and psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Genetics of psoriasis and psoriatic arthritis: update and future direction.
Global partnering opportunities and challenges of psoriasis and psoriatic arthritis in Latin America: a report from the GRAPPA 2010 annual meeting.
GRAPPA 2007: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis.
GRAPPA 2013 Annual Meeting, rheumatology updates: psoriatic arthritis (PsA) biomarker project, arthritis mutilans, PsA-peripheral spondyloarthritis epidemiology project.
GRAPPA 2017 Project Report.
GRAPPA Responder Index Project (GRACE): a report from the GRAPPA 2011 annual meeting.
GRAPPA Trainees Symposium 2009: a report from the GRAPPA 2009 annual meeting.
GRAPPA Trainees Symposium 2010: a report from the GRAPPA 2010 annual meeting.
GRAPPA Trainees Symposium 2013: a report from the GRAPPA 2013 Annual Meeting.
GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting.
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2008.
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis - GRAPPA (2003-2013).
Imaging in psoriasis and psoriatic arthritis: GRAPPA 2008.
Infectious, oncologic, and autoimmune comorbidities of psoriasis and psoriatic arthritis: a report from the GRAPPA 2012 annual meeting.
Instruments Measuring Physical Function for Psoriatic Arthritis Endorsed at GRAPPA 2020 Annual Meeting: Updates of the GRAPPA-OMERACT Working Group.
Magnetic resonance imaging in psoriatic arthritis -- update on current status and future perspectives: a report from the GRAPPA 2010 annual meeting.
Nail Enthesis Ultrasound in Psoriasis and Psoriatic Arthritis: A Report from the 2016 GRAPPA Annual Meeting.
New GRAPPA recommendations for the management of psoriasis and psoriatic arthritis: process, challenges and implementation.
Options for Assessing Joints and Entheses in Psoriatic Arthritis by Ultrasonography and Magnetic Resonance Imaging: How to Move Forward.
Outcome measures for psoriasis severity: a report from the GRAPPA 2012 annual meeting.
Outcomes research in psoriasis and psoriatic arthritis using large databases and research networks: a report from the GRAPPA 2013 Annual Meeting.
Overview of the Grant Writing Workshop From the GRAPPA 2020 Annual Meeting.
Patient participation in psoriasis and psoriatic arthritis outcome research: a report from the GRAPPA 2013 Annual Meeting.
Polyphenotypic Psoriasis: A Report from the GRAPPA 2016 Annual Meeting.
Practical Assessment of Psoriasis Clinical Severity in both Clinical Trials and Clinical Practice Settings: A Report from the GRAPPA 2016 Annual Meeting.
Presidential Round Table: A Report from the GRAPPA Annual Meeting.
Proceedings of the GRAPPA 2016 Retreat.
Prologue: 2010 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2011 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2012 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2013 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2016 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Psoriasis and psoriatic arthritis educational initiatives: an update from the 2013 GRAPPA Annual Meeting.
Psoriasis and psoriatic arthritis in Peruvian aborigines: a report from the GRAPPA 2011 annual meeting.
Psoriasis and Psoriatic Arthritis in the Context of the COVID-19 Pandemic: A Plenary Session From the GRAPPA 2020 Annual Meeting.
Psoriasis and Psoriatic Arthritis Video Project 2010: a report from the GRAPPA annual meeting.
Psoriasis and psoriatic arthritis video project: an update from the 2010 GRAPPA annual meeting.
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting.
Psoriasis and psoriatic arthritis video project: an update from the GRAPPA 2011 annual meeting.
Psoriasis Epidemiology Screening Tool (PEST): a report from the GRAPPA 2009 annual meeting.
Psoriasis outcome measures: a report from the GRAPPA 2012 annual meeting.
Psoriatic arthritis and psoriasis projects in Italy: a report from the GRAPPA 2011 annual meeting.
Rehabilitation in psoriatic arthritis.
Summary of the International Federation of Psoriasis Associations (IFPA) meeting: a report from the GRAPPA 2009 annual meeting.
The Benefits and Challenges of Setting Up a Longitudinal Psoriatic Arthritis Database.
The GRAPPA-OMERACT Psoriatic Arthritis Working Group at the 2018 Annual Meeting: Report and Plan for Completing the Core Outcome Measurement Set.
The GRAPPA-OMERACT Working Group: 4 Prioritized Domains for Completing the Core Outcome Measurement Set for Psoriatic Arthritis 2019 Updates.
The need to define musculoskeletal inflammation: a report from the GRAPPA 2010 annual meeting.
The Role of Ultrasound in Research and Clinical Practice in Psoriatic Arthritis: Highlights From the GRAPPA Ultrasound Workshop.
Toronto Psoriatic Arthritis Screening (ToPAS) questionnaire: a report from the GRAPPA 2009 annual meeting.
Treatment strategies for early psoriatic arthritis.
Treatments for nail psoriasis: a systematic review by the GRAPPA Nail Psoriasis Work Group.
Update on Biomarkers in Psoriatic Arthritis.
Rheumatic Diseases
GRAPPA at the European League Against Rheumatism (EULAR) 2008.
Spinal Diseases
Inflammatory spinal disease in psoriatic arthritis: a report from the GRAPPA 2010 annual meeting.
Spondylitis
Development of criteria to distinguish inflammatory from noninflammatory arthritis, enthesitis, dactylitis, and spondylitis: a report from the GRAPPA 2013 Annual Meeting.
Development of simple clinical criteria for the definition of inflammatory arthritis, enthesitis, dactylitis, and spondylitis: a report from the GRAPPA 2012 annual meeting.
Prologue: 2012 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
Prologue: 2013 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
The need to define musculoskeletal inflammation: a report from the GRAPPA 2010 annual meeting.
Spondylitis, Ankylosing
Therapies for axial disease in psoriatic arthritis. A systematic review.
Vascular Diseases
Time-resolved 3D contrast-enhanced MRA with GRAPPA on a 1.5-T system for imaging of craniocervical vascular disease: initial experience.