Information on EC 1.5.1.10 - saccharopine dehydrogenase (NADP+, L-glutamate-forming)

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The expected taxonomic range for this enzyme is: Opisthokonta

EC NUMBER
COMMENTARY
1.5.1.10
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RECOMMENDED NAME
GeneOntology No.
saccharopine dehydrogenase (NADP+, L-glutamate-forming)
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Lysine biosynthesis
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lysine biosynthesis IV
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Lysine degradation
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
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SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminoadipate semialdehyde-glutamate reductase
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aminoadipic semialdehyde-glutamate reductase
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aminoadipic semialdehyde-glutamic reductase
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dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming)
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epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)
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saccharopine dehydrogenase
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saccharopine dehydrogenase (L-glutamate forming)
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saccharopine reductase
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saccharopine reductase
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saccharopine reductase
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CAS REGISTRY NUMBER
COMMENTARY
9033-55-0
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ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
low activity
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Manually annotated by BRENDA team
serotype A, strain H99, human pathogen, chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9)
SwissProt
Manually annotated by BRENDA team
gene lys7, strain Wis 54-1255
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Manually annotated by BRENDA team
low activity
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Manually annotated by BRENDA team
fission yeast
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Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
ENGINEERING
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
additional information
Q6RXX2
construction of 3 Spe3-Lys9 mutants, with defects in the spe3-part, the lys9-part, or both, which are auxotrophic for lysine and spermidine, spermidine, and lysine, respectively, transcription levels and phenotype overview, the polyamine auxotrophy due to defect spe3 cannot be overcome by spermine addition, while the mutan with lys 9 defect grows slowly at 30°C with lysine addition, but dies upon lysine starvation, the mutant with defects in both gene parts is avirulent and lethal
additional information
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construction of an enzyme-deficient mutant strain: disruption and inactivation of gene lys7 by double-recombination method leads to lysine auxotrophy and accumulation of piperideine-6-carboxylic acid, and with L-lysine as sole N-source and supplementation of DL-alpha-aminoadipic acid, also of pipecolic acid, transformation of the mutant strain with lys7 can restore enzyme activity