Disease on EC 1.3.1.72 - DELTA24-sterol reductase
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Adenoma
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Adrenal Gland Neoplasms
Seladin-1 expression is regulated by promoter methylation in adrenal cancer.
Adrenocortical Adenoma
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
Adrenocortical Adenoma
The human homolog of Diminuto/Dwarf1 gene (hDiminuto): a novel ACTH-responsive gene overexpressed in benign cortisol-producing adrenocortical adenomas.
Alzheimer Disease
Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer.
Alzheimer Disease
Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer's Disease Mice.
Alzheimer Disease
DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3? signaling in A?25-35 treated BV-2 cells.
Alzheimer Disease
Down-regulation of seladin-1 increases bace1 levels and activity through enhanced GGA3 depletion during apoptosis.
Alzheimer Disease
Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.
Alzheimer Disease
Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1.
Alzheimer Disease
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Alzheimer Disease
Gender dependent effect of DHCR24 polymorphism on the risk for Alzheimer's disease.
Alzheimer Disease
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Alzheimer Disease
Heme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease.
Alzheimer Disease
Hippocampal DHCR24 down regulation in a rat model of streptozotocin-induced cognitive decline.
Alzheimer Disease
Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation.
Alzheimer Disease
Interactions of Aromatase and Seladin-1: A Neurosteroidogenic and Gender Perspective.
Alzheimer Disease
Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1).
Alzheimer Disease
Membrane cholesterol as a mediator of the neuroprotective effects of estrogens.
Alzheimer Disease
Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1.
Alzheimer Disease
Neuronal differentiation of rat hair follicle stem cells: the involvement of the neuroprotective factor Seladin-1 (DHCR24).
Alzheimer Disease
New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm.
Alzheimer Disease
Prescription of lipophilic statins to Alzheimer's disease patients: some controversies to consider.
Alzheimer Disease
Recombinant adenovirus-mediated overexpression of 3?-hydroxysteroid-?24 reductase.
Alzheimer Disease
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
Alzheimer Disease
Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease.
Alzheimer Disease
Serum seladin-1 levels in diabetes mellitus and Alzheimer's disease patients.
Alzheimer Disease
Statin-like drugs for the treatment of brain cholesterol loss in Alzheimer's disease.
Alzheimer Disease
The association study between DHCR24 polymorphisms and Alzheimer's disease.
Alzheimer Disease
The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene.
Alzheimer Disease
Upregulation of seladin-1 and nestin expression in bone marrow mesenchymal stem cell transplantation via the ERK1/2 and PI3K/Akt signaling pathways in an Alzheimer's disease model.
Alzheimer Disease
[Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis]
Breast Neoplasms
24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway.
Carcinogenesis
Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers.
Carcinoma
DHCR24 is an Independent Predictor of Progression in Patients with Non-Muscle-Invasive Urothelial Carcinoma, and Its Functional Role is Involved in the Aggressive Properties of Urothelial Carcinoma Cells.
Carcinoma, Hepatocellular
Development of Serum DHCR24 Antibody as a Marker for Hepatocellular Carcinoma: The End of the Beginning.
Carcinoma, Hepatocellular
Genomic polymorphisms in 3?-hydroxysterol ?24-reductase promoter sequences.
Cardiomyopathy, Dilated
Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice.
Cataract
Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition.
Chondrodysplasia Punctata
Genetic disorders of cholesterol biosynthesis in mice and humans.
Cystadenocarcinoma, Mucinous
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
Cystadenocarcinoma, Serous
Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.
delta24-sterol reductase deficiency
Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay.
delta24-sterol reductase deficiency
DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3?/mTOR Signaling.
delta24-sterol reductase deficiency
Phenotypic spectrum of fetal Smith-Lemli-Opitz syndrome.
Diabetes Mellitus
Serum seladin-1 levels in diabetes mellitus and Alzheimer's disease patients.
Diabetes Mellitus, Type 2
3?-Hydroxysteroid-?24 Reductase (DHCR24) Protects Pancreatic ? Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species.
Diabetic Neuropathies
Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system: the involvement of the neuroprotective factor DHCR24 (Seladin-1).
Dwarfism
Dominant and pleiotropic effects of a GAI gene in wheat results from a lack of interaction between DELLA and GID1.
Dwarfism
The maize DWARF1 encodes a gibberellin 3-oxidase and is dual localized to the nucleus and cytosol.
Endometrial Neoplasms
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Epilepsy
Interactions of Aromatase and Seladin-1: A Neurosteroidogenic and Gender Perspective.
Hepatitis C
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Hepatitis C
Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase.
Hepatitis, Chronic
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Herpes Zoster
24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex.
Herpes Zoster
Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment.
Hypercholesterolemia
Desmosterol in brain is elevated because DHCR24 needs REST for Robust Expression but REST is poorly expressed.
Hypothyroidism
Crosstalk between thyroid hormone receptor and liver X receptor in the regulation of selective Alzheimer's disease indicator-1 gene expression.
Infections
3?-Hydroxysteroid-?24 Reductase (DHCR24) Protects Pancreatic ? Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Scavenging Excessive Intracellular Reactive Oxygen Species.
Infections
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Infections
Blood-based gene expression profile of oxidative stress and antioxidant genes for identifying surrogate markers of liver tissue injury in chronic hepatitis C patients.
Infections
Hepatitis C virus impairs P53 via persistent over-expression of 3{beta}-hydroxysterol {delta}24-reductase.
Infections
Oxidative Stress and Immune Responses During Hepatitis C Virus Infection in Tupaia belangeri.
Infections
The heterotrimeric G protein alpha subunit acts upstream of the small GTPase Rac in disease resistance of rice.
Leishmaniasis
Hesperidin Targets Leishmania donovani Sterol C-24 Reductase to Fight against Leishmaniasis.
Liver Cirrhosis
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Liver Diseases
Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C.
Lymphatic Metastasis
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Malnutrition
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Melanoma
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.
Metabolism, Inborn Errors
Genetic disorders of cholesterol biosynthesis in mice and humans.
Mevalonate Kinase Deficiency
Genetic disorders of cholesterol biosynthesis in mice and humans.
Myocardial Infarction
MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24.
Neoplasm Metastasis
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.
Neoplasm Metastasis
Evolution of the androgen receptor pathway during progression of prostate cancer.
Neoplasm Metastasis
MicroRNA Profiling and Target Genes Related to Metastasis of Salivary Adenoid Cystic Carcinoma.
Neoplasms
24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway.
Neoplasms
An Integrative In Silico Mathematical Modelling Study of The Anti-Cancer Effect of Clove Extract ( Syzygium aromaticum ) Combined with In Vitro Metabolomics Study Using 1HNMR Spectroscopy.
Neoplasms
Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma.
Neoplasms
DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis.
Neoplasms
DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study.
Neoplasms
Editorial: Is the diminuto/dwarf1 gene involved in physiologic adrenocortical size regulation and tumor formation?
Neoplasms
Evolution of the androgen receptor pathway during progression of prostate cancer.
Neoplasms
Gene expression in normal urothelium depends on location within the bladder: a possible link to bladder carcinogenesis.
Neoplasms
Polybrominated diphenyl ethers cause oxidative stress in human umbilical vein endothelial cells.
Neoplasms
Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness.
Neoplasms
Seladin-1 is a novel lipopolysaccharide (LPS)-responsive gene and inhibits the tumour necrosis factor-alpha production and osteoclast formation in response to LPS.
Neoplasms, Germ Cell and Embryonal
Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness.
Neuroblastoma
3 ?-hydroxysteroid-? 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress.
Neuroblastoma
Aromatase/Seladin-1 Interactions in Human Neuronal Cell Culture, the Hippocampus of Healthy Rats and Transgenic Alzheimer's Disease Mice.
Neuroblastoma
Down-regulation of seladin-1 increases bace1 levels and activity through enhanced GGA3 depletion during apoptosis.
Neuroblastoma
Membrane cholesterol as a mediator of the neuroprotective effects of estrogens.
Neuroblastoma
Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice.
Neuroblastoma
Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content.
Neuroblastoma
The membrane topological analysis of 3?-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.
Neurodegenerative Diseases
Estrogen and selective estrogen receptor modulators exert neuroprotective effects and stimulate the expression of selective Alzheimer's disease indicator-1, a recently discovered antiapoptotic gene, in human neuroblast long-term cell cultures.
Neurodegenerative Diseases
Identification and analysis of the promoter region of the human DHCR24 gene: involvement of DNA methylation and histone acetylation.
Neuroinflammatory Diseases
DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.
Ototoxicity
Inhibition of DHCR24 increases the cisplatin-induced damage to cochlear hair cells in vitro.
Peritonitis
Inhibition of ?24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution.
Pheochromocytoma
3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis.
Pituitary Neoplasms
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas.
Prostatic Neoplasms
Inhibition of DHCR24/Seladin-1 impairs cellular homeostasis in prostate cancer.
Prostatic Neoplasms
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.
Smith-Lemli-Opitz Syndrome
Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments.
Tauopathies
DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3?/mTOR Signaling.
Tauopathies
DHCR24 Knockdown Lead to Hyperphosphorylation of Tau at Thr181, Thr231, Ser262, Ser396, and Ser422 Sites by Membrane Lipid-Raft Dependent PP2A Signaling in SH-SY5Y Cells.
Urinary Bladder Neoplasms
DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study.
Urinary Bladder Neoplasms
Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells.
Virus Diseases
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Wilms Tumor
Gene expression during ovarian differentiation in parasitic and non-parasitic lampreys: implications for fecundity and life history types.
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