Information on EC 1.3.1.53 - (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase

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The expected taxonomic range for this enzyme is: Comamonas testosteroni

EC NUMBER
COMMENTARY hide
1.3.1.53
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RECOMMENDED NAME
GeneOntology No.
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH
show the reaction diagram
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(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH + H+
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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-
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redox reaction
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reduction
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-toluenecarboxylate degradation
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Metabolic pathways
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Microbial metabolism in diverse environments
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Polycyclic aromatic hydrocarbon degradation
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SYSTEMATIC NAME
IUBMB Comments
(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase
Requires FeII. Involved in the terephthalate degradation pathway in bacteria [2].
CAS REGISTRY NUMBER
COMMENTARY hide
162032-77-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
T-2
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Manually annotated by BRENDA team
strain YZW-D
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+
Protocatechuic acid + NADH + CO2
show the reaction diagram
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+
3,4-dihydroxybenzoate + CO2 + NADH
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+
Protocatechuic acid + NADH + CO2
show the reaction diagram
cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+
3,4-dihydroxybenzoate + CO2 + NADH
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Fe2+
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activates
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.09
(1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate
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0.043
NAD+
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE