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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
additional information
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25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP1A2 compared to marker enzyme CYP3A4
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
cholesterol 25-hydroxylase has the capacity to play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein processing and ultimately leads to inhibition of gene transcription
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
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genetic variability in the set of cholesterol metabolism genes: cholesterol 25-hydroxylase, cholesterol 24-hydroxylase and ATP-binding cassette transporter A1 does not influence the development of Alzheimers disease
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the enzyme has the capacity to synthesize an active and potent regulator of the sterol response element binding protein pathway within the cell
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2C9 compared to marker enzyme CYP3A4
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
lower 25-hydroxylation enzyme activity by CYP2D6 compared to marker enzyme CYP3A4
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
production of 25-hydroxycholesterol by intact CYP3A4, most significant activity is 25-hydroxylation, which is higher than that of 4beta-hydroxylation, a marker activity of CYP3A4
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cholesterol + AH2 + O2
25-hydroxycholesterol + A + H2O
the reaction might be catalyzed by CYP3A4
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abc-type xenobiotic transporter deficiency
P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a.
Arthritis
Effect of interleukin-6 neutralization on CYP3A11 and metallothionein-1/2 expressions in arthritic mouse liver.
Atherosclerosis
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome.
Atherosclerosis
KLF4 Regulation of Ch25h and LXR Mitigates Atherosclerosis Susceptibility.
Bacterial Infections
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Breast Neoplasms
The role of pregnane x receptor in 2-acetylaminofluorene-mediated induction of drug transport and -metabolizing enzymes in mice.
cholesterol 25-monooxygenase
deficiency
Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.
Colitis
Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function.
Colitis
The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.
Colitis
The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.
Colorectal Neoplasms
Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.
Dermatitis, Contact
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Encephalomyelitis
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Encephalomyelitis, Autoimmune, Experimental
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Gastroenteritis
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Gastroenteritis, Transmissible, of Swine
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Hepatitis C
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Hepatitis C
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Herpes Simplex
Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein.
Infections
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
Infections
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Infections
A balanced game: chicken macrophage response to ALV-J infection.
Infections
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Infections
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.
Infections
Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways.
Infections
Cholesterol 25-hydroxylase inhibits encephalomyocarditis virus replication through enzyme activity-dependent and independent mechanisms.
Infections
Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication through Enzyme Activity-Dependent and -Independent Mechanisms.
Infections
Cholesterol 25-hydroxylase inhibits Senecavirus A replication by enzyme activity-dependent and independent mechanisms.
Infections
Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.
Infections
Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol.
Infections
Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry.
Infections
Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Infections
Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol.
Infections
Downregulation of Hepatic Cytochrome P450 3A in Mice Infected with Babesia microti.
Infections
Endogenous Retrovirus ev21 Dose Not Recombine with ALV-J and Induces the Expression of ISGs in the Host.
Infections
Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry.
Infections
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Infections
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Infections
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Infections
Listeria monocytogenes Infection Induces Prosurvival Metabolic Signaling in Macrophages.
Infections
Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques.
Infections
Modulation of hepatic cytochrome P450s by citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Infections
Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities.
Infections
Porcine reproductive and respiratory syndrome virus E protein degrades porcine cholesterol 25-hydroxylase via the ubiquitin-proteasome pathway.
Infections
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Infections
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol.
Infections
Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions.
Infections
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Influenza, Human
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
Insulin Resistance
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.
Insulin Resistance
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Leukodystrophy, Globoid Cell
Expression of Ripk1 and DAM genes correlates with severity and progression of Krabbe disease.
Liver Neoplasms
Role of PXR in Hepatic Cancer: Its Influences on Liver Detoxification Capacity and Cancer Progression.
Malaria
Malaria infection alters the expression of hepatobiliary and placental drug transporters in pregnant mice.
Melanoma
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Melanoma
Extracellular vesicles in cancer progression.
Melanoma
Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene.
Multiple Sclerosis
Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Neoplasm Metastasis
An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Neoplasm Metastasis
Extracellular vesicles in cancer progression.
Neoplasms
Downregulation of drug transport and metabolism in mice bearing extra-hepatic malignancies.
Neoplasms
Extracellular vesicles in cancer progression.
Neoplasms
Helicobacter hepaticus-Induced Liver Tumor Promotion Is Associated with Increased Serum Bile Acid and a Persistent Microbial-Induced Immune Response.
Neoplasms
IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages.
Neoplasms
Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver.
Neoplasms
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.
Neoplasms
Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.
Neoplasms
Selective role for tumor necrosis factor-?, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen.
Neoplasms
Skin response to a carcinogen involves the xenobiotic receptor pregnane X receptor.
Neuromyelitis Optica
Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Non-alcoholic Fatty Liver Disease
Modulation of xenobiotic nuclear receptors in high-fat diet induced non-alcoholic fatty liver disease.
Obesity
Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.
Obesity
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Obesity, Metabolically Benign
Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice.
Osteoarthritis
Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes.
Osteoarthritis
The CH25H-CYP7B1-ROR? axis of cholesterol metabolism regulates osteoarthritis.
Paralysis
Functional coupling of ATP binding cassette transporter Abcb6 to Cytochrome P450 expression and activity in liver.
Porcine Reproductive and Respiratory Syndrome
Porcine reproductive and respiratory syndrome virus nsp1? and nsp11 antagonize the antiviral activity of cholesterol-25-hydroxylase via lysosomal degradation.
Pseudorabies
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication.
Pulmonary Disease, Chronic Obstructive
25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-?B dependent pathway.
Pulmonary Disease, Chronic Obstructive
Cholesterol metabolism promotes B-cell positioning during immune pathogenesis of chronic obstructive pulmonary disease.
Rabies
Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Reoviridae Infections
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Reperfusion Injury
The prominent impairment of liver/intestinal cytochrome P450 and intestinal drug transporters in sepsis-induced acute kidney injury over acute and chronic renal ischemia, a mouse model comparison.
Rift Valley Fever
Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities.
Sarcoma, Experimental
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer.
Vesicular Stomatitis
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
Viremia
Interferon-independent antiviral activity of 25-hydroxycholesterol in a teleost fish.
Virus Diseases
25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Virus Diseases
Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.
Virus Diseases
Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination.
Virus Diseases
Antiviral activity of porcine interferon delta 8 against pesudorabies virus in vitro.
Virus Diseases
Cholesterol 25-Hydroxylase inhibits bovine parainfluenza virus type 3 replication through enzyme activity-dependent and -independent ways.
Virus Diseases
Cholesterol-25-Hydroxylase Suppresses Seneca Valley Virus Infection via Producing 25-Hydroxycholesterol to Block Adsorption Procedure.
Virus Diseases
Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes.
Virus Diseases
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Virus Diseases
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms.
Virus Diseases
Interferons: Reprogramming the Metabolic Network against Viral Infection.
Virus Diseases
Regulating Innate and Adaptive Immunity for Controlling SIV Infection by 25-Hydroxycholesterol.
Zika Virus Infection
25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.
Zika Virus Infection
IL-1?/TNF-?/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in zika virus-infected human macrophages.
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Russell, D.W.
Oxysterol biosynthetic enzymes
Biochim. Biophys. Acta
1529
126-135
2000
Homo sapiens (O95992), Mus musculus (Q9Z0F5)
brenda
Lund, E.G.; Kerr, T.A.; Sakai, J.; Li, W.P.; Russell, D.W.
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism
J. Biol. Chem.
273
34316-34327
1998
Homo sapiens (O95992), Mus musculus (Q9Z0F5)
brenda
Shibata, N.; Kawarai, T.; Lee, J.H.; Lee, H.S.; Shibata, E.; Sato, C.; Liang, Y.; Duara, R.; Mayeux, R.P.; St George-Hyslop, P.H.; Rogaeva, E.
Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
Neurosci. Lett.
391
142-146
2006
Homo sapiens
brenda
Papassotiropoulos, A.; Lambert, J.C.; Wavrant-De Vrieze, F.; Wollmer, M.A.; von der Kammer, H.; Streffer, J.R.; Maddalena, A.; Huynh, K.D.; Wolleb, S.; Lutjohann, D.; Schneider, B.; Thal, D.R.; Grimaldi, L.M.; Tsolaki, M.; Kapaki, E.; Ravid, R.; Konietzko, U.; Hegi, T.; Pasch, T.; Jung, H.; Braak, H.
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimers disease
Neurodegener. Dis.
2
233-241
2005
Homo sapiens
brenda
Diczfalusy, U.; Olofsson, K.; Carlsson, A.; Gong, M.; Golenbock, D.; Rooyackers, O.; Flring, U.; Bjrkbacka, H.
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
J. Lipid Res.
50
2258-2264
2009
Homo sapiens, Mus musculus
brenda
Holmes, R.S.; Vandeberg, J.L.; Cox, L.A.
Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H)
3 Biotech
1
99-109
2011
Bos taurus (Q0P599), Canis lupus familiaris, Equus caballus (F6T000), Gallus gallus, Homo sapiens (O95992), Homo sapiens, Macaca mulatta (F7EC50), Mus musculus (Q9Z0F5), Rattus norvegicus (Q4QQV7), Xenopus tropicalis
brenda
Diczfalusy, U.
On the formation and possible biological role of 25-hydroxycholesterol
Biochimie
95
455-460
2013
Rattus norvegicus, Sus scrofa, Homo sapiens (Q02318), Mus musculus (Q64459)
brenda
Honda, A.; Miyazaki, T.; Ikegami, T.; Iwamoto, J.; Maeda, T.; Hirayama, T.; Saito, Y.; Teramoto, T.; Matsuzaki, Y.
Cholesterol 25-hydroxylation activity of CYP3A
J. Lipid Res.
52
1509-1516
2011
Homo sapiens (P05177), Homo sapiens (P08684), Homo sapiens (P10635), Homo sapiens (P11712), Mus musculus (Q9Z0F5)
brenda
Anggakusuma, G.; Romero-Brey, I.; Berger, C.; Colpitts, C.C.; Boldanova, T.; Engelmann, M.; Todt, D.; Perin, P.M.; Behrendt, P.; Vondran, F.W.; Xu, S.; Goffinet, C.; Schang, L.M.; Heim, M.H.; Bartenschlager, R.; Pietschmann, T.; Steinmann, E.
Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Hepatology
62
702-714
2015
Homo sapiens (Q95992), Homo sapiens
brenda
Xiang, Y.; Tang, J.J.; Tao, W.; Cao, X.; Song, B.L.; Zhong, J.
Identification of cholesterol 25-hydroxylase as a novel host restriction factor and a part of the primary innate immune responses against hepatitis C virus infection
J. Virol.
89
6805-6816
2015
Homo sapiens
brenda
Chen, Y.; Wang, S.; Yi, Z.; Tian, H.; Aliyari, R.; Li, Y.; Chen, G.; Liu, P.; Zhong, J.; Chen, X.; Du, P.; Su, L.; Qin, F.X.; Deng, H.; Cheng, G.
Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms
Sci. Rep.
4
7242
2014
Homo sapiens (Q95992)
brenda
Tsujioka, T.; Yokoi, A.; Itano, Y.; Takahashi, K.; Ouchida, M.; Okamoto, S.; Kondo, T.; Suemori, S.; Tohyama, Y.; Tohyama, K.
Five-aza-2-deoxycytidine-induced hypomethylation of cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells
Sci. Rep.
5
16709
2015
Homo sapiens (Q95992)
brenda