Disease on EC 1.1.1.95 - phosphoglycerate dehydrogenase

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DISEASE
TITLE OF PUBLICATION
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6,7-dihydropteridine reductase deficiency
Cerebral folate deficiency.
Adenocarcinoma
Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3.
Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
Anemia
On the phenotypic spectrum of serine biosynthesis defects.
aromatic-l-amino-acid decarboxylase deficiency
Cerebral folate deficiency.
Asthma
Fatal cerebral edema associated with serine deficiency in CSF.
Brain Diseases
Early onset West syndrome with cerebral hypomyelination and reduced cerebral white matter.
Two new cases of serine deficiency disorders treated with l-serine.
Brain Ischemia
Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia.
Brain Neoplasms
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.
Breast Neoplasms
A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
Bioinformatics analysis of the serine and glycine pathway in cancer cells.
Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis.
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate.
Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth.
Resurgence of serine: an often neglected but indispensable amino Acid.
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Carcinogenesis
Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3.
Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes.
Genetically-defined metabolic reprogramming in cancer.
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.
Carcinoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer.
Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
Carcinoma, Hepatocellular
Enzymic imbalance in serine metabolism in rat hepatomas.
Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liver.
The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture.
Carcinoma, Squamous Cell
Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer.
Colitis
Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer.
Colorectal Neoplasms
Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer.
Epilepsy, Absence
Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency.
Gastritis
Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer.
Glioma
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.
Hepatitis B, Chronic
[Cloning and expression of 3-phosphoglycerate dehydrogenase gene and its correlative antibodies in diagnosis of autoimmune hepatitis]
Hepatitis C, Chronic
[Cloning and expression of 3-phosphoglycerate dehydrogenase gene and its correlative antibodies in diagnosis of autoimmune hepatitis]
Hepatitis, Autoimmune
Detection of D-3-phosphoglycerate dehydrogenase autoantibodies in patients with autoimmune hepatitis: Clinical significance evaluation.
[Cloning and expression of 3-phosphoglycerate dehydrogenase gene and its correlative antibodies in diagnosis of autoimmune hepatitis]
Hyperglycinemia, Nonketotic
Reference data for cerebrospinal fluid and the utility of amino acid measurement for the diagnosis of inborn errors of metabolism.
Infection
Artemether Exhibits Amoebicidal Activity against Acanthamoeba castellanii through Inhibition of the Serine Biosynthesis Pathway.
Kearns-Sayre Syndrome
Cerebral folate deficiency.
Keloid
Upregulation of the NNP-1 (novel nuclear protein-1, D21S2056E) gene in keloid tissue determined by cDNA microarray and in situ hybridization.
Leukemia
Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth.
Lung Neoplasms
Bioinformatics analysis of the serine and glycine pathway in cancer cells.
Lymphoma
Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
Melanoma
Cancer's sweet tooth for serine.
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate.
p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.
PHGDH amplification and altered glucose metabolism in human melanoma.
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.
Microcephaly
3-phosphoglycerate dehydrogenase deficiency: a case report of a treatable cause of seizures.
Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids.
Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency.
Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency.
Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges
Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.
Neu-Laxova syndrome, an inborn error of serine metabolism, is caused by mutations in PHGDH.
On the phenotypic spectrum of serine biosynthesis defects.
Phenotypic heterogeneity and adverse effects of serine treatment in 3-phosphoglycerate dehydrogenase deficiency: report on two siblings.
Treatment with amino acids in serine deficiency disorders.
Two new cases of serine deficiency disorders treated with l-serine.
V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.
Nasopharyngitis
EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma.
Neoplasm Metastasis
Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer.
Neoplasms
An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.
Artemether Exhibits Amoebicidal Activity against Acanthamoeba castellanii through Inhibition of the Serine Biosynthesis Pathway.
Cancer's sweet tooth for serine.
Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.
Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis.
Correction for Mullarky et al., Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3.
Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs).
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Expression of metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma.
Expression of serine and glycine-related enzymes in phyllodes tumor.
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes.
Genetically-defined metabolic reprogramming in cancer.
High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy.
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate.
Hypoxia-inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype.
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer.
Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis.
Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
p73 regulates serine biosynthesis in cancer.
PHGDH amplification and altered glucose metabolism in human melanoma.
PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.
Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1.
Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer.
Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth.
Phosphoglycerate dehydrogenase: potential therapeutic target and putative metabolic oncogene.
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin.
Resurgence of serine: an often neglected but indispensable amino Acid.
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Neurotoxicity Syndromes
Fatal cerebral edema associated with serine deficiency in CSF.
Obesity
Target identification of the novel antiobesity agent tungstate in adipose tissue from obese rats.
Optic Atrophy
Early onset West syndrome with cerebral hypomyelination and reduced cerebral white matter.
Phenylketonurias
Cerebral folate deficiency.
phosphoglycerate dehydrogenase deficiency
3-Phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency: inborn errors of serine biosynthesis.
3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome.
3-phosphoglycerate dehydrogenase deficiency: a case report of a treatable cause of seizures.
3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.
3-phosphoglycerate dehydrogenase deficiency: description of two new cases in Tunisia and review of the literature.
A Serine Synthesis Defect Presenting With a Charcot-Marie-Tooth-Like Polyneuropathy.
Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency.
Cerebral folate deficiency.
Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids.
Continuing education in neurometabolic disorders--serine deficiency disorders.
Early onset West syndrome with cerebral hypomyelination and reduced cerebral white matter.
Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency.
Fatal cerebral edema associated with serine deficiency in CSF.
Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy.
Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency.
Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges
Neurotransmitters in 3-phosphoglycerate dehydrogenase deficiency.
Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics.
Phenotypic heterogeneity and adverse effects of serine treatment in 3-phosphoglycerate dehydrogenase deficiency: report on two siblings.
Prenatal and early postnatal treatment in 3-phosphoglycerate-dehydrogenase deficiency.
Reference data for cerebrospinal fluid and the utility of amino acid measurement for the diagnosis of inborn errors of metabolism.
Treatment with amino acids in serine deficiency disorders.
V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.
phosphoserine phosphatase deficiency
3-Phosphoglycerate dehydrogenase deficiency and 3-phosphoserine phosphatase deficiency: inborn errors of serine biosynthesis.
Continuing education in neurometabolic disorders--serine deficiency disorders.
Treatment with amino acids in serine deficiency disorders.
Phyllodes Tumor
Expression of serine and glycine-related enzymes in phyllodes tumor.
Polyneuropathies
A Serine Synthesis Defect Presenting With a Charcot-Marie-Tooth-Like Polyneuropathy.
Rett Syndrome
Cerebral folate deficiency.
Sarcoma
Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma.
Seizures
3-phosphoglycerate dehydrogenase deficiency: a case report of a treatable cause of seizures.
Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency.
Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids.
Expanding the clinical spectrum of 3-phosphoglycerate dehydrogenase deficiency.
Genetic disorders of gamma-aminobutyric acid, glycine, and serine as causes of epilepsy.
Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.
Phenotypic heterogeneity and adverse effects of serine treatment in 3-phosphoglycerate dehydrogenase deficiency: report on two siblings.
Treatment with amino acids in serine deficiency disorders.
V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme.
Spasms, Infantile
3-phosphoglycerate dehydrogenase deficiency in a patient with West syndrome.
Early onset West syndrome with cerebral hypomyelination and reduced cerebral white matter.
Starvation
p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.
Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liver.
Stillbirth
On the phenotypic spectrum of serine biosynthesis defects.
Stomach Neoplasms
Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer.
Strabismus
3-phosphoglycerate dehydrogenase deficiency: a case report of a treatable cause of seizures.
Triple Negative Breast Neoplasms
Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin.
Tuberculosis
A Novel Mechanism for Substrate Inhibition in Mycobacterium tuberculosis D-3-Phosphoglycerate Dehydrogenase.
Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits.
D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes.
Kinetic Evidence of a Noncatalytic Substrate Binding Site That Regulates Activity in Legionella pneumophilal-Serine Dehydratase.
Kinetic, mutagenic, and structural homology analysis of L-serine dehydratase from Legionella pneumophila.
Regulation of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase by phosphate-modulated quaternary structure dynamics and a potential role for polyphosphate in enzyme regulation.
Role of the Anion-Binding Site in Catalysis and Regulation of Mycobacterium tuberculosis d-3-Phosphoglycerate Dehydrogenase.
Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.
Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor.
Uterine Cervical Neoplasms
Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer.