Information on EC 1.1.1.211 - long-chain-3-hydroxyacyl-CoA dehydrogenase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY hide
1.1.1.211
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RECOMMENDED NAME
GeneOntology No.
long-chain-3-hydroxyacyl-CoA dehydrogenase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a long-chain (S)-3-hydroxyacyl-CoA + NAD+ = a long-chain 3-oxoacyl-CoA + NADH + H+
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
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redox reaction
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-
-
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reduction
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(8E,10E)-dodeca-8,10-dienol biosynthesis
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Biosynthesis of unsaturated fatty acids
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Fatty acid degradation
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Fatty acid elongation
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Metabolic pathways
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Spodoptera littoralis pheromone biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
This enzyme was purified from the mitochondrial inner membrane. The enzyme has a preference for long-chain substrates, and activity with a C16 substrate was 6- to 15-fold higher than with a C4 substrate (cf. EC 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase).
CAS REGISTRY NUMBER
COMMENTARY hide
84177-52-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
neonatal
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-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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the placenta of an 8-month-old child diagnosed with long-chain 3-hydroxyacyl coenzyme A dehydrogenase (LCHAD) deficiency shows maternal floor infarction/massive perivillous fibrin, MFI/MPVFD, phenotype, overview
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-hydroxyoctanoyl-CoA + NAD+
3-ketooctanoyl-CoA + NADH
show the reaction diagram
-
-
-
-
?
3-ketohexadecanoyl-CoA + NADH
3-hydroxyhexadecanoyl-CoA + NAD+
show the reaction diagram
3-ketohexanoyl-CoA + NADH
3-hydroxyhexanoyl-CoA + NAD+
show the reaction diagram
3-oxodecanoyl-CoA + NADH
3-hydroxydecanoyl-CoA + NAD+
show the reaction diagram
acetoacetyl-CoA + NADH
3-hydroxybutyryl-CoA + NAD+
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
defatted serum albumin
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
defatted serum albumin
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.2 - 7.4
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3-hydroxyoctanoyl-CoA oxidation
15 - 35
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3-ketohexadecanoyl-CoA reduction
16.3
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3-ketohexadecanoyl-CoA reduction
30.4
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3-ketohexadecanoyl-CoA reduction
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
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assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
adult and fetal
Manually annotated by BRENDA team
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fetal, strong expression
Manually annotated by BRENDA team
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developing, fetal, strong expression
Manually annotated by BRENDA team
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fetal, strong expression
Manually annotated by BRENDA team
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adult and fetal
Manually annotated by BRENDA team
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neural, developing
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
additional information
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long-chain fatty acid oxidation during fetal and early human development, overview
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
47000
-
alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE
51000
alpha4beta4, 4 * 79000 + 4 * 51000, SDS-PAGE
71000
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alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE
79000
alpha4beta4, 4 * 79000 + 4 * 51000, SDS-PAGE
186000
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liver, gel filtration
230000
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liver, gel filtration
460000
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
octamer
alpha4beta4, 4 * 79000 + 4 * 51000, SDS-PAGE
tetramer
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alpha2,beta2, 1 * 71000 + 1 * 47000, SDS-PAGE
additional information
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
trifunctional enzyme: 2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-oxoacyl-CoA thiolase
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis of genomic DNA from a women who survived acute fatty liver in pregnancy, the women does not carry the G1528C polymorphism
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into XbaI- and HindIII-digested pK18mobsacB, resulting in plasmid pKXZ01
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G1528C
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a common polymorphism, which is probably not involved in enzyme deficiency in acute fatty liver in pregnancy
Q358K
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heterozygous mutation in exon 11, 1072C/A, a naturally mutation occuring in the LCHAD coding region, HADHA, causing growth-restriction in a 25-4/7 week gestation female infant
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
degradation
medicine