6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase

This is an abbreviated version!
For detailed information about phosphoribosylaminoimidazolesuccinocarboxamide synthase, go to the full flat file.

Word Map on EC 6.3.2.6

6.3.2.6

purine

carboxylase

paics

ribotide

adenylosuccinate

4.1.1.21

horikoshii

drug development

medicine

Reaction

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

Synonyms

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide synthetase, 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase, 5-Aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase, ade5, AIRc-SAICARs, ATPase, BaPurC, CCM_04437, MjSS, More, N-(5-Amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5�-phosphate synthetase, PAICS, PH0239, PH0239 protein, phosphoribosylaminoimidazole succinocarboxamide synthetase, phosphoribosylaminoimidazole-succinocarboxamide synthase, phosphoribosylaminoimidazole-succinocarboxamide synthetase, Phosphoribosylaminoimidazolesuccinocarboxamide synthetase, PhSS, PurC, PurC gene product, PurCE, SAICAR synthase, SAICAR synthetase, spPurC, Succino-AICAR synthetase, Synthetase, phosphoribosylaminoimidazolesuccinocarboxamide, VEG286A, Vegetative protein 286A

ECTree

6 Ligases

6.3 Forming carbon-nitrogen bonds

6.3.2 Acid—amino-acid ligases (peptide synthases)

6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase

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Results	in table
43893	AA Sequence
4	Application
1	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
13	Crystallization (Commentary)
20	Disease/ Diagnostics
3	Expression
25	General Information
2	General Stability
5	Inhibitors
15	Ki Value [mM]
4	KM Value [mM]
14	Metals/Ions
15	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
50	Organism
8	Pathway
67	PDB ID
3	pH Optimum
1	pH Stability
14	Purification (Commentary)
1	Reaction
2	Reaction Type
48	Reference
20	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
57	Substrates and Products (Substrate)
27	Subunits
84	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
5	Temperature Stability [°C]

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Application on EC 6.3.2.6 - phosphoribosylaminoimidazolesuccinocarboxamide synthase

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drug development

3 entries

medicine

Homo sapiens

phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) is an important bifunctional enzyme in de novo purine biosynthesis in vertebrate with both 5-aminoimidazole ribonucleotide carboxylase (AIRc) and 4-(N-succinylcarboxamide)-5-aminoimidazole ribonucleotide synthetase (SAICARs) activities. It is an attractive target for rational anticancer drug design, since rapidly dividing cancer cells rely heavily on the purine de novo pathway for synthesis of adenine and guanine, whereas normal cells favor the salvage pathway

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