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6.2.1.44: 3-(methylthio)propionyl-CoA ligase

This is an abbreviated version!
For detailed information about 3-(methylthio)propionyl-CoA ligase, go to the full flat file.

Word Map on EC 6.2.1.44

Reaction

ATP
+
3-(methylsulfanyl)propanoate
+
CoA
=
AMP
+
diphosphate
+
3-(methylsulfanyl)propanoyl-CoA

Synonyms

3-methylmercaptopropionyl-CoA ligase, BTH_DmdB2, BTH_I2141, DmdB, methylmercaptopropionate-coenzyme A ligase, MMPA-CoA ligase, PA4198, PA_DmdB1, PU_DmdB1, RL_DmdB1, RL_DmdB2, RPO_DmdB1, RPO_DmdB2, SAR11_0248, SL1157_1815, SL1157_2728, SPO0677, SPO2045

ECTree

     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.44 3-(methylthio)propionyl-CoA ligase

Expression

Expression on EC 6.2.1.44 - 3-(methylthio)propionyl-CoA ligase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the amount of transcripts for dmdB, dmdC and dmdD increases during growth of wild-type enzyme on 3-(methylthio)propanoate or 3-(dimethylsulphonio)propanoate, as expected if the pathway is required for 3-(methylthio)propanoate metabolism
two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2. They are differentially expressed depending on carbon source. RPO_dmdB1 exhibits overall lower steady-state levels of mRNA than RPO_dmdB2 for dimethylsulfoniopropionate, 3-(methylthio)propanoate, or methionine as the sole source of carbon. Although the levels of the RPO_dmdB1 transcripts increases during growth on dimethylsulfoniopropionate and methionine, it is always lower than those of RPO_dmdB2. For that reason, RPO_dmdB2 appears to be the major DmdB during growth on compounds leading to 3-(methylthio)propanoate formation