5.5.1.B6: nogalonic acid methyl ester cyclase

This is an abbreviated version!
For detailed information about nogalonic acid methyl ester cyclase, go to the full flat file.

Reaction

Synonyms

AcmA, aklanonic acid methyl ester cyclase, AknH

ECTree

     5 Isomerases

         5.5 Intramolecular lyases

             5.5.1 Intramolecular lyases (only sub-subclass identified to date)

                5.5.1.B6 nogalonic acid methyl ester cyclase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
1	AA Sequence
1	Cloned(Commentary)
1	Crystallization (Commentary)
1	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
5	Protein Variants
1	Reference
2	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 5.5.1.B6 - nogalonic acid methyl ester cyclase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Natural Substrate Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

aklanonic acid methyl ester

?

Streptomyces galilaeus

O52646

-

732336

-

-

?

nogalonic acid methyl ester

auraviketone

Streptomyces galilaeus

O52646

-

732336

product has (R)-configuration at C9, ring closure is an intramolecular aldol condensation. The attack of the enol(ate) is on the si face of the C9 carbonyl group, required for the formation of the C9-R stereoisomer, which results in the alcoholate anion pointing away from the carboxyl side-chain of Asp121

-

?