5.4.3.10: phenylalanine aminomutase (L-beta-phenylalanine forming)

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For detailed information about phenylalanine aminomutase (L-beta-phenylalanine forming), go to the full flat file.

Word Map on EC 5.4.3.10

5.4.3.10

taxus

ammonia

enantioselectivity

stereochemistry

regioselectivity

enantiopure

pantoea

chinensis

biocatalytic

isomerizes

agglomerans

isomerization

prosthesis

trans-cinnamic

e-cinnamate

enantiomeric

biocatalyst

unnatural

acrylate

canadensis

rebind

pro-3s

beta-amino

lyases

non-natural

lyase-like

n-benzoyl

intramolecularly

beta-isomer

Reaction

Synonyms

(R)-PAM, (R)-selective PAM, admH, CctP, More, PAM, phenylalanine AM, phenylalanine aminomutase, phenylalanine-2,3-aminomutase, TcPAM

ECTree

5 Isomerases

5.4 Intramolecular transferases

5.4.3 Transferring amino groups

5.4.3.10 phenylalanine aminomutase (L-beta-phenylalanine forming)

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Results	in table
1	Activating Compound
4	AA Sequence
3	Cloned(Commentary)
8	Cofactor
4	Crystallization (Commentary)
14	General Information
13	kcat/KM [mM/s]
14	KM Value [mM]
7	Natural Substrates/ Products (Substrates)
9	Organism
3	Pathway
2	PDB ID
13	Protein Variants
1	Purification (Commentary)
5	Reaction
9	Reference
23	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Turnover Number [1/s]

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Reference on EC 5.4.3.10 - phenylalanine aminomutase (L-beta-phenylalanine forming)

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719657

Ratnayake, N.D.; Wanninayake, U.; Geiger, J.H.; Walker, K.D.

Stereochemistry and mechanism of a microbial phenylalanine aminomutase

J. Am. Chem. Soc.

133

8531-8533

2011

Pantoea agglomerans

21561099

721637

Feng, L.; Wanninayake, U.; Strom, S.; Geiger, J.; Walker, K.

Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase

Biochemistry

2919-2930

2011

Taxus canadensis (Q6GZ04), Taxus canadensis

21361343

746591

Heberling, M.; Masman, M.; Bartsch, S.; Wybenga, G.; Dijkstra, B.; Marrink, S.; Janssen, D.

Ironing out their differences Dissecting the structural determinants of a phenylalanine aminomutase and ammonia lyase

ACS Chem. Biol.

989-997

2015

Taxus chinensis (Q68G84), Taxus canadensis (Q6GZ04)

747524

Parmeggiani, F

; Weise, N.J.; Ahmed, S.T.; Turner, N.J. Synthetic and therapeutic applications of ammonia-lyases and aminomutases

Chem. Rev.

118

73-118

2018

Aster tataricus, Pelliciarosea asterica, Talaromyces islandicus (A0A0U1LSP0), Taxus chinensis (Q68G84)

28497955

747670

Zhu, L.; Ge, F.; Li, W.; Song, P.; Tang, H.; Tao, Y.; Liu, Y.; Du, G.

One step synthesis of unnatural beta-arylalanines using mutant phenylalanine aminomutase from Taxus chinensis with high beta-regioselectivity

Enzyme Microb. Technol.

114

22-28

2018

Taxus chinensis (Q68G83), Taxus chinensis

29685349