This is an abbreviated version! For detailed information about 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase, go to the full flat file.
catalytic mechanism involves long loops on the catayltic face that enclose the substrate. Substrate ProFAR adopts an extended conformation where its non-reacting half is in a product-like conformation. This change is associated with shifts in a hydrogen bond network including residues His47, Asp129, Thr171, and Ser202
catalytic mechanism involves long loops on the catayltic face that enclose the substrate. Substrate ProFAR adopts an extended conformation where its non-reacting half is in a product-like conformation. This change is associated with shifts in a hydrogen bond network including residues His47, Asp129, Thr171, and Ser202