4.3.1.29: D-glucosaminate-6-phosphate ammonia-lyase
This is an abbreviated version!
For detailed information about D-glucosaminate-6-phosphate ammonia-lyase, go to the full flat file.
Reaction
Synonyms
D-glucosaminate-6-phosphate ammonia lyase, D-glucosaminic acid 6-phosphate dehydratase, DgaE, DGL
ECTree
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Substrates Products
Substrates Products on EC 4.3.1.29 - D-glucosaminate-6-phosphate ammonia-lyase
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REACTION DIAGRAM
6-phospho-D-glucosaminate
2-dehydro-3-deoxy-6-phospho-D-gluconate + NH3
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2-dehydro-3-deoxy-6-phospho-D-gluconate + NH3
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2-amino-2-deoxy-D-gluconate 6-phosphate
2-dehydro-3-deoxy-6-phospho-D-gluconate + NH3
the enzyme is highly efficient and highly specific for 2-amino-2-deoxy-D-gluconate 6-phosphate. A mechanism is proposed that requires a second catalytic base located on the D-face of the substrate-pyridoxal-5'-phosphate complex. Deprotonation is followed by elimination of water to give an aminoacrylate intermediate, which tautomerizes and undergoes hydrolysis to give the product, 2-dehydro-3-deoxygluconate-6-phosphate
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