4.2.3.149: nephthenol synthase

This is an abbreviated version!
For detailed information about nephthenol synthase, go to the full flat file.

Reaction

Synonyms

DtcycA, DtcycB

ECTree

     4 Lyases

         4.2 Carbon-oxygen lyases

             4.2.3 Acting on phosphates

                4.2.3.149 nephthenol synthase

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Results	in table
2	AA Sequence
1	Cloned(Commentary)
2	KM Value [mM]
1	Metals/Ions
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
2	Reference
6	Substrates and Products (Substrate)
4	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 4.2.3.149 - nephthenol synthase

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SYSTEMATIC NAME

IUBMB Comments

geranylgeranyl-diphosphate diphosphate-lyase [(R)-nephthenol-forming]

Requires Mg2+. Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404. The enzyme encoded by the DtcycA gene also produces cembrene C (see EC 4.2.3.148, cembrene C synthase), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13-pentamethylcyclopentadeca-4,8,12-trien-1-ol (see EC 4.2.3.150, cembrene A synthase, and EC 4.2.3.151, pentamethylcyclopentadecatrienol synthase).