4.2.3.136: alpha-isocomene synthase

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For detailed information about alpha-isocomene synthase, go to the full flat file.

Word Map on EC 4.2.3.136

4.2.3.136

transposase

musca

hobo

repeat-type

syllabus

Reaction

Synonyms

MrTPS2, TPS2

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.136 alpha-isocomene synthase

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Results	in table
1	AA Sequence
2	Organism
1	Protein Variants
2	Reaction
2	Reference
3	Source Tissue
2	Substrates and Products (Substrate)
3	Synonyms
1	Systematic Name

Substrates Products

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Substrates Products on EC 4.2.3.136 - alpha-isocomene synthase

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(2E,6E)-farnesyl diphosphate

(-)-alpha-isocomene + diphosphate

Matricaria chamomilla

I6R4V5

reaction mechanism most likely involves repeated cycles of protonation/deprotonation of a neutral (-)-(E)-beta-caryophyllene intermediate. The deprotonation of the final isocomyl carbocation can occur either at C1 or C13, resulting in the main product alpha-isocomene and the minor product beta-isocomene

729600

(2E,6E)-farnesyl diphosphate

alpha-isocomene + diphosphate

Matricaria chamomilla var. recutita

MrTPS2 shows a broader sesquiterpene product spectrum with the angular triquinane, alpha-isocomene, being the main compound. The enzyme produces detectable amounts of three other triquinanes, beta-isocomene, silphinene and modeph-2-ene. Like MrTPS1 it also produces (E)-beta-caryophyllene and alpha-humulene, but in low amounts

719187