4.2.3.126: gamma-muurolene synthase

This is an abbreviated version!
For detailed information about gamma-muurolene synthase, go to the full flat file.

Reaction

Synonyms

Cop3, SasesquiTPS1, sesquiterpene synthase

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.3 Acting on phosphates

4.2.3.126 gamma-muurolene synthase

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Results	in table
16	AA Sequence
3	Cloned(Commentary)
3	General Information
1	KM Value [mM]
3	Metals/Ions
5	Natural Substrates/ Products (Substrates)
4	Organism
1	pH Optimum
2	Protein Variants
1	Purification (Commentary)
1	Reaction
4	Reference
9	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Engineering

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Engineering on EC 4.2.3.126 - gamma-muurolene synthase

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Go to Protein Variants Search

H255P

Coprinopsis cinerea

site-directed mutagenesis, modification of the H-alpha1 loop, the mutant shows highly altered product profile compared to the wild-type enzyme, it does no longer produce gamma-muurolene but large amounts of germacrene A (77%), overview

713839

K251I

Coprinopsis cinerea

site-directed mutagenesis, modification of the H-alpha1 loop, the mutant shows only slightly altered product profile compared to the wild-type enzyme, it produces also beta-copaene, cf. EC 4.2.3.127, overview

713839