4.2.2.8: heparin-sulfate lyase

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For detailed information about heparin-sulfate lyase, go to the full flat file.

Word Map on EC 4.2.2.8

4.2.2.8

proteoglycans

glycosaminoglycans

chondroitinase

chondroitin

endothelial

oligosaccharide

basement

dermatan

heparin-binding

hspgs

bfgf

disaccharide

hyaluronidase

heparinum

hyaluronic

nitrous

perlecan

flavobacterium

chlorate

neuraminidase

3hglucosamine

fgf-2

antithrombin

n-sulfated

iduronic

lyases

glycocalyx

35ssulfate

keratanase

heparin-like

proteoheparan

inner-core

analysis

heptose

cetylpyridinium

beta-d-xyloside

trifluoromethanesulfonic

synthesis

sulfate-containing

heparanase

glycosaminoglycan-degrading

densa

35so4-labeled

hno2

cuprolinic

6-o-sulfate

sulfate-binding

glypican-1

Reaction

2-amino-2-deoxy-4-O-alpha-L-threo-hex-4-enopyranuronosyl-beta-D-glucopyranose

Synonyms

BT4657, Hep I, Hep III, heparan sulfate lyase, heparin lyase, heparin lyase III, heparin sulfate eliminase, heparin-sulfate eliminase, heparinase I, heparinase III, heparitin sulfate lyase, heparitin-sulfate lyase, heparitinase, heparitinase I, heparitinase II, HepI, HepIII, lyase, heparin sulfate

ECTree

4 Lyases

4.2 Carbon-oxygen lyases

4.2.2 Acting on polysaccharides

4.2.2.8 heparin-sulfate lyase

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Results	in table
179	AA Sequence
2	Application
1	CAS Registry Number
7	Cloned(Commentary)
3	Crystallization (Commentary)
137	Disease/ Diagnostics
2	General Information
1	General Stability
22	Inhibitors
1	Ki Value [mM]
20	KM Value [mM]
7	Metals/Ions
3	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
30	Organism
1	Pathway
2	PDB ID
8	pH Optimum
1	pH Range
1	pI Value
47	Protein Variants
8	Purification (Commentary)
2	Reaction
2	Reaction Type
29	Reference
1	Renatured (Commentary)
3	Source Tissue
6	Specific Activity [micromol/min/mg]
2	Storage Stability
55	Substrates and Products (Substrate)
3	Subunits
31	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
17	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 4.2.2.8 - heparin-sulfate lyase

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alpha-lactose

Ca2+

Cd2+

1 mM

Cu2+

Dextran

diethyl dicarbonate

inactivation, 80% reversible by hydroxylamine within 6 h, mapping of modified histidine residues

649969

DTT

Pedobacter heparinus

suppresses the dimerization

glycerol

Hg2+

1 mM

LG1PS

50% inhibition at 470 æM

37411

N-acetylheparin

Flavobacteriia

5978

Pb2+

Bacteroides stercoris

1 mM: 0% activity

PEG 20000

PEG 8000

sucrose

suramin

50% inhibition at 350 æM

trehalose

Triton X-100

Tween 80

Zn2+