4.1.99.20: 3-amino-4-hydroxybenzoate synthase

This is an abbreviated version!
For detailed information about 3-amino-4-hydroxybenzoate synthase, go to the full flat file.

Reaction

Synonyms

3,4-AHBA synthase, griH

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.99 Other carbon-carbon lyases

                4.1.99.20 3-amino-4-hydroxybenzoate synthase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
44	AA Sequence
1	Application
2	Cloned(Commentary)
1	Expression
1	General Information
1	Inhibitors
1	KM Value [mM]
4	Metals/Ions
2	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
2	Organism
8	Pathway
1	pH Optimum
1	pH Range
1	pH Stability
1	Protein Variants
1	Reaction
2	Reference
4	Substrates and Products (Substrate)
1	Subunits
3	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 4.1.99.20 - 3-amino-4-hydroxybenzoate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

Streptomyces griseus

A0JC76

3-amino-4-hydroxybenzoic acid (3,4-AHBA) is a metabolic intermediate of grixazone biosynthesis in Streptomyces griseus and is synthesized by the activities of the enzymes GriI and GriH, which are encoded by griI and griH, respectively. GriI catalyzes an aldol condensation reaction between L-aspartate-4-semialdehyde and dihydroxyacetone phosphate, and GriH converts the resulting C7 metabolite into 3,4-AHBA. Through this two-step reaction, these two enzymes can produce an aromatic ring from C4 (L-aspartate-4-semialdehyde) and C3 (dihydroxyacetone phosphate) primary metabolites, whereas most aromatic compounds, including aromatic amino acids, are formed in a multistep reaction via the shikimate pathway

747305