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3.4.23.29: Polyporopepsin

This is an abbreviated version!
For detailed information about Polyporopepsin, go to the full flat file.

Word Map on EC 3.4.23.29

Reaction

Milk clotting activity, broad specificity, but fails to cleave Leu15-Tyr or Tyr16-Leu of insulin B chain =

Synonyms

Acid protease, aspartic protease, Aspartic proteinase, EC 3.4.4.17, ILAP, Irpex lacteus aspartic protease, Irpex lacteus aspartic proteinase, Irpex lacteus carboxyl proteinase B, milk-clotting enzyme, More, Polyporus aspartic proteinase, Proteinase, Irpex lacteus aspartic

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.29 Polyporopepsin

Substrates Products

Substrates Products on EC 3.4.23.29 - Polyporopepsin

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-Phe-Gly-Ala + H2O
Ala-Phe + Gly-Ala
show the reaction diagram
-
-
-
?
Ala-Phe-Leu-Ala + H2O
Ala-Phe + Leu-Ala
show the reaction diagram
-
-
-
?
alpha1-casein + H2O
?
show the reaction diagram
-
cleavage of Phe23-Phe24 and Lys103-Tyr104 bonds at pH 6.0
-
-
?
angiotensin I + H2O
Asp-Arg-Val-Tyr-Ile-His-Pro + Phe-His-Leu
show the reaction diagram
-
hydrolyzes Tyr4-Ile5 bond much more rapidly than the Val3-Tyr4 bond
-
-
?
beta-casein + H2O
?
show the reaction diagram
-
cleavage of Leu165-Ser166, Ala189-Phe190, and Leu192-Tyr193 bonds, no cleavage of Leu139-Leu140 and Ser142-Trp143 bonds
-
-
?
casein + H2O
?
show the reaction diagram
-
-
-
-
?
FVNQHLCGSHLVEALYLVCGERGFFYTPKA + H2O
FVNQHLCGSHL + VEA + LYLVCGERGF + FYT + PKA
show the reaction diagram
-
i.e. insulin B chain, cleavage site specificity at pH 3.0.the Ala14-Leu15 bond is preferred
-
-
?
Gly-Phe-Leu-Ala + H2O
Gly-Phe + Leu-Ala
show the reaction diagram
-
-
-
?
Hemoglobin + H2O
?
show the reaction diagram
-
-
-
-
?
Hemoglobin + H2O
Proteolytically cleaved hemogobin
show the reaction diagram
-
-
-
-
?
kappa-casein + H2O
?
show the reaction diagram
-
cleavage of Phe105-Met106 bond
-
-
?
Oxidized B-chain of insulin + H2O
Proteolytically cleaved insulin B-chain
show the reaction diagram
-
peptide bonds mainly susceptible to the enzyme: Leu11-Val12, Ala14-Leu15, Phe24-Phe25, Thr27-Pro28
-
-
?
Phe-Ala-Ala-Ala + H2O
Phe-Ala + Ala-Ala
show the reaction diagram
-
-
-
?
Phe-Glu-Ala-Ala + H2O
Phe-Glu + Ala-Ala
show the reaction diagram
-
-
-
?
Phe-Gly-Ala-Ala + H2O
Phe-Gly + Ala-Ala
show the reaction diagram
-
-
-
?
Phe-Leu-Ala-Ala + H2O
Phe-Leu + Ala-Ala
show the reaction diagram
-
-
-
?
Phe-Lys-Ala-Ala + H2O
Phe-Lys + Ala-Ala
show the reaction diagram
-
-
-
?
Phe-Tyr-Ala-Ala + H2O
Phe-Tyr + Ala-Ala
show the reaction diagram
-
-
-
?
additional information
?
-