3.4.22.B35: calpain 15
This is an abbreviated version!
For detailed information about calpain 15, go to the full flat file.
Reaction
broad endopeptidase specificity =
Synonyms
CAPN15, small optic lobes calpain, small optic lobes protein, SOL calpain
ECTree
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General Information
General Information on EC 3.4.22.B35 - calpain 15
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physiological function
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SOL calpain zinc fingers bind poly- but not mono- or diubiquitin. No specific zinc finger is required for polyubiquitin binding. Neither polyubiquitin nor calcium is sufficient to induce purified SOL calpain to autolyse or to cleave the atypical protein kinase C to protein kinase M in vitro. In Aplysia californica, overexpression of the atypical protein kinase C in sensory neurons leads to an activity-dependent cleavage event and an increase in nuclear ubiquitin staining. Activity-dependent cleavage is partially blocked by a dominant negative SOL calpain
physiological function
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SOL calpain zinc fingers bind to ubiquitin. No specific zinc finger is required for polyubiquitin binding