3.4.21.49: hypodermin C
This is an abbreviated version!
For detailed information about hypodermin C, go to the full flat file.
Word Map on EC 3.4.21.49
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3.4.21.49
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hypodermins
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lineatum
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larvae
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cattle
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hypodermosis
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infest
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oestridae
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instar
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grub
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warble
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diptera
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seroprevalence
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bovis
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hide
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pugilator
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reindeer
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collagenases
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collagenolytic
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tarandi
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first-instars
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medicine
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ivermectin
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diagnostics
- 3.4.21.49
-
hypodermins
- lineatum
- larvae
- cattle
-
hypodermosis
-
infest
- oestridae
-
instar
- grub
-
warble
-
diptera
-
seroprevalence
- bovis
-
hide
- pugilator
- reindeer
- collagenases
-
collagenolytic
- tarandi
-
first-instars
- medicine
- ivermectin
- diagnostics
Reaction
Hydrolysis of proteins including native collagen at -/-Ala bond leaving an N-terminal (75%) and a C-terminal (25%) fragment =
Synonyms
HyC, hyperdermin C, hypoderma collagenase
ECTree
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General Information
General Information on EC 3.4.21.49 - hypodermin C
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physiological function
additional information
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hypodermin C does not modulate the production of the cytokines interleukin-10, interleukin-4, or interferon-gamma
physiological function
hypodermin C protease degrades the guinea pig complement C3, and inhibits the complement pathway in vitro, immunosuppressive effect of hypodermin C on complement component 3 in vitro, the cytotoxicity of C3 is inhibited in cultures of stably transfected COS7 cells expressing the enzyme
physiological function
the enzyme is involved in the larval migration in the tissue and prevents the activation of the host immune response. The enzyme displays an immunosuppressive effect on complement component 3 in vitro
identification of the DNA binding sites of the enzyme using an electrophoretic mobility shift asay
additional information
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identification of the DNA binding sites of the enzyme using an electrophoretic mobility shift asay