3.1.15.1: venom exonuclease
This is an abbreviated version!
For detailed information about venom exonuclease, go to the full flat file.
Word Map on EC 3.1.15.1
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3.1.15.1
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lysophosphatidic
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lysophospholipase
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lysophosphatidylcholine
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duplex
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endonuclease
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strand
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metastasis
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fibrosis
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rnase
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single-stranded
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nucleases
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lysophospholipids
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polymerases
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polynucleotide
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phosphorothioate
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5'-nucleotidase
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adp-ribose
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adp-ribosylation
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oligodeoxynucleotides
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pruritus
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adp-ribosyltransferase
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oligodeoxyribonucleotides
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itch
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phosphodiesterases
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dinucleoside
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exonucleolytic
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ectonucleotide
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internucleotide
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phosphoramidite
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proofreading
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deoxyribonuclease
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nucleolytic
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3'-terminus
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deoxynucleoside
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medicine
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oligoribonucleotides
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micrococcal
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abasic
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molecular biology
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lpa-induced
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32p-postlabeling
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klenow
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nuclease-resistant
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adamanteus
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postlabeling
- 3.1.15.1
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lysophosphatidic
- lysophospholipase
- lysophosphatidylcholine
- duplex
- endonuclease
- strand
- metastasis
- fibrosis
- rnase
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single-stranded
- nucleases
- lysophospholipids
- polymerases
- polynucleotide
- phosphorothioate
- 5'-nucleotidase
- adp-ribose
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adp-ribosylation
- oligodeoxynucleotides
- pruritus
- adp-ribosyltransferase
- oligodeoxyribonucleotides
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itch
- phosphodiesterases
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dinucleoside
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exonucleolytic
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ectonucleotide
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internucleotide
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phosphoramidite
-
proofreading
- deoxyribonuclease
-
nucleolytic
- 3'-terminus
- deoxynucleoside
- medicine
- oligoribonucleotides
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micrococcal
-
abasic
- molecular biology
-
lpa-induced
-
32p-postlabeling
-
klenow
-
nuclease-resistant
- adamanteus
-
postlabeling
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =
Synonyms
3'-exonuclease, 5'-exonuclease, 5'-nucleotide phosphodiesterase, alkaline phosphodiesterase, autotaxin, Crotalus adamenteus venom exonuclease, PDE, PDE-I, posphodiesterase I, snake venom phosphodiesterase, snake venom phosphodiesterase I, snake venom phosphodiesterase-I, SVP, SVPD, SVPDE, TS-PDE, venom exonuclease I, venom PDE-I, venom phosphodiesterase, venom phosphodiesterase I, VLPDE
ECTree
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Inhibitors
Inhibitors on EC 3.1.15.1 - venom exonuclease
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2-([4-deoxy-4-(hydroxymethyl)-3-O-(phenylcarbonyl)-beta-D-glucopyranosyl]oxy)-5-hydroxybenzyl benzoate
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IC50: 0.171 mM
2-([4-deoxy-4-(hydroxymethyl)-beta-D-glucopyranosyl]oxy)-5-hydroxybenzyl benzoate
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IC50: 0.544 mM
4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)((E)-2-phenylethenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(1H-indol-2-yl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(1H-pyrol-2-yl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(2-bromophenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(2-chlorophenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(2-methoxyphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(2-pyridinyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(2-thienyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3,4,5-trimethoxyphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3,4-dimethoxyphenyl) methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-aminophenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-chlorophenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-ethoxyphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-hydroxyphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-methoxyphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-nitrophenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-pyridinyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(3-thienyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-hydroxy-3-ethoxyphenyl) methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-isopropylphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-methoxyphenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-N,N-dimethylaminophenyl) methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-nitrophenyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)(4-pyridinyl)methyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)ethyl]-2H-chromen-2-one
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4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
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Cu2+
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required for activity, but inhibitory at 1 mM, two Cu2+ binding sites. Cu2+ ions function as a switch for its phosphodiesterase activity
dithiothreitol
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inhibits the phosphodiesterase activity of the enzyme by reducing both the Cu2+ and disulfide bonds
L-ascorbate
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endogenous inhibitor, inhibits the phosphodiesterase activity of the enzyme through reduction of Cu2+
quinovic acid-3-O-alpha-L-rhamnopyranoside
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significant inhibitory activity against the enzyme
quinovic acid-3-O-beta-D-fucopyranoside
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significant inhibitory activity against the enzyme
quinovic acid-3-O-beta-D-glucopyranosyl (1-> 4)-beta-D-fucopyranoside
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significant inhibitory activity against the enzyme
tris(2-carboxyethyl)phosphine
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inhibits the phosphodiesterase activity of the enzyme by reducing both the Cu2+ and disulfide bonds
additional information
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calf intestine alkaline phosphatase-independent SVPD termini are piperidine resistant
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EDTA
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strong inhibition, addition of 10 mM Ca2+ restored only 8% of the enzyme activity
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endogenous inhibitor, inhibits the phosphodiesterase activity of the enzyme by reducing both the Cu2+ and disulfide bonds