2.7.7.23: UDP-N-acetylglucosamine diphosphorylase

This is an abbreviated version!
For detailed information about UDP-N-acetylglucosamine diphosphorylase, go to the full flat file.

Reaction

Synonyms

acetylglucosamine 1-phosphate uridylyltransferase, AGX-1, AGX1, AGX2, amino-sugar-1-phosphate acetyltransferase, bifunctional N-acetyltransferase/uridylyltransferase, BmUAP, CL6EHI_021200, CL6EHI_039830, EcGlmU, EnhiA.01126.a, EnhiA.01126.b, GlcNAc-1-P uridyltransferase, GlcNAc-1-P UTase, GlcNAc-1-phosphate nucleotidylyltransferase, GLCNAC1PUT1, GLCNAC1PUT2, GlmU, GlmUMTB, hiGlmU, LmUAP1, LmUAP2, LOC_Os08g10600, Mmy, More, mummy, N-acetyl-D-glucosamine-1-phosphate uridylyltransferase, N-acetyl-glucosamine-1-phosphate uridyltransferase, N-acetylglucosamine 1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate uridyltransferase, N-acetylglucosamine-1-phosphate uridylyltransferase, N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase, Os08g10600, Rv1018c, spl29, spotted leaf 29, ST0452, ST0452 protein, STK_04520, Tb11.02.0120, UAP, UAP enzyme, UAP1, UAP2, UDP N-acetylglucosamine pyrophosphorylases 1, UDP N-acetylglucosamine pyrophosphorylases 2, UDP-GlcNAc pyrophosphorylase, UDP-GlcNAc pyrophosphorylase (UAP), UDP-HexNAc pyrophosphorylase, UDP-N-acetylgalactosamine pyrophosphorylase, UDP-N-acetylglucosamine diphosphorylase 1, UDP-N-acetylglucosamine diphosphorylase 2, UDP-N-acetylglucosamine pyrophosphorylase, UDP-N-acetylglucosamine pyrophosphorylase (UAP), UDP-N-acetylglucosamine pyrophosphorylase 1, UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase, UDP-N-acetylglucosamine-diphosphorylase, UDP-N-acetylhexosamine pyrophosphorylase, UDPacetylglucosamine pyrophosphorylase, UNAcP, uridine diphosphate N-acetylglucosamine pyrophosphorylase, uridine diphosphate-N-acetylglucosamine pyrophosphorylase, uridine diphosphoacetylglucosamine phosphorylase, uridine diphosphoacetylglucosamine pyrophosphorylase, uridine-diphospho-N-acetylglucosamine pyrophosphorylase, UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase, UTP:N-acetylglucosamine-1-P uridylyltransferase, Ydl103c protein

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.7 Nucleotidyltransferases

                2.7.7.23 UDP-N-acetylglucosamine diphosphorylase

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Results	in table
8	Activating Compound
29531	AA Sequence
17	Application
1	CAS Registry Number
49	Cloned(Commentary)
2	Cofactor
22	Crystallization (Commentary)
35	Disease/ Diagnostics
11	Expression
98	General Information
8	General Stability
55	IC50 Value
146	Inhibitors
30	kcat/KM [mM/s]
7	Ki Value [mM]
76	KM Value [mM]
7	Localization
77	Metals/Ions
36	Molecular Weight [Da]
139	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
477	Organism
9	Pathway
84	PDB ID
40	pH Optimum
5	pH Range
2	pH Stability
4	pI Value
1	Posttranslational Modification
247	Protein Variants
48	Purification (Commentary)
2	Reaction
1	Reaction Type
126	Reference
60	Source Tissue
73	Specific Activity [micromol/min/mg]
15	Storage Stability
258	Substrates and Products (Substrate)
38	Subunits
215	Synonyms
1	Systematic Name
30	Temperature Optimum [°C]
3	Temperature Range [°C]
5	Temperature Stability [°C]
42	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.7.23 - UDP-N-acetylglucosamine diphosphorylase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00996

(Z)-4-(4-(benzyloxy)benzylidene)-2-(naphthalen-1-yl)oxazol-5(4H)-one

Mycobacterium tuberculosis

P9WMN3

pH 7.4, 37°C

737150

0.0087

2-2-[(6-nitroquinazolin-4-yl)amino]ethoxy)-ethan-1-ol

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.0087

2-[2-[(6-nitroquinazolin-4-yl)amino]ethoxy]-ethan-1-ol

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.037

3-[2-(1,3-benzodioxol-5-yl)-2-oxoethyl]-4-bromo-3-hydroxy-5-methyl-1,3-dihydro-2H-indol-2-one

Trypanosoma brucei brucei

Q386Q8

pH not specified in the publication, temperature not specified in the publication

737319

0.037

3-[2H-(1,3-benzodioxol-5-yl)-2-oxoethyl]-4-bromo-3-hydroxy-5-methyl-1,3-dihydro-2H-indol-2-one

Trypanosoma brucei

-

pH 7.5, temperature not specified in the publication

737319

0.2

4-(5-[(6-nitroquinazolin-4-yl)amino]-1,3,4-thiadiazol-2-yl)phenol

Mycobacterium tuberculosis

P9WMN3

above, pH and temperature not specified in the publication

760857

0.042

4-(6-nitroquinazolin-4-ylamino)benzoic acid

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.018

4-chloro-N-(3-methoxypropyl)-N-[1-(2-phenylethyl)piperidin-3-yl]benzamide

Haemophilus influenzae

P43889

-

706622

0.1

4-chloro-N-[1-[2-(2-fluorophenyl)ethyl]piperidin-3-yl]-N-(3-methoxypropyl)benzamide

Haemophilus influenzae

P43889

value above

706622

0.1

4-chloro-N-[1-[2-(3-fluorophenyl)ethyl]piperidin-3-yl]-N-(3-methoxypropyl)benzamide

Haemophilus influenzae

P43889

value above

706622

0.089

4-chloro-N-[1-[2-(4-fluorophenyl)ethyl]piperidin-3-yl]-N-(3-methoxypropyl)benzamide

Haemophilus influenzae

P43889

-

706622

0.02

4-fluoro-N-(3-methoxypropyl)-N-[1-(2-phenylethyl)piperidin-3-yl]benzamide

Haemophilus influenzae

P43889

-

706622

0.2

4-methyl-7-[(6-nitroquinazolin-4-yl)amino]-2H-1-benzopyran-2-one

2 entries

0.026

4-[(6-nitroquinazolin-4-yl)amino]-N-(pyrimidin-2-yl)benzene-1-sulfonamide

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.2

4-[5-[(6-nitroquinazolin-4-yl)amino]-1,3,4-thiadiazol-2-yl]phenol

Mycobacterium tuberculosis

P9WMN3

IC50 above 0.2 mM, pH and temperature not specified in the publication

760857

0.016

6-nitro-N-(1,3-thiazol-2-yl)quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.021

6-nitro-N-(3,4,5-trimethoxyphenyl)quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.2

6-nitro-N-(5-phenyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine

2 entries

0.023

6-nitro-N-(pyridin-2-ylmethyl)quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.2

6-nitro-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]quinazolin-4-amine

2 entries

0.021

6-nitro-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.00081

luteolin

Xanthomonas oryzae pv. oryzae

Q2P7P9

pH 7.5, 37°C

719411

0.023

N'-[(4-chloro-3,5-dimethylphenoxy)acetyl]-2,4-dihydroxybenzohydrazide

Xanthomonas oryzae pv. oryzae

Q2P7P9

pH 7.5, 37°C

719411

0.014

N'1,N'6-bis[2-(naphthalen-2-yloxy)acetyl]hexanedihydrazide

Xanthomonas oryzae pv. oryzae

Q2P7P9

pH 7.5, 37°C

719411

0.0029

N-(1-benzylpiperidin-4-yl)-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.052

N-(2,4-dimethylphenyl)-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.049

N-(3,5-dimethoxyphenyl)-2,3-dihydro-4H-1,4-benzothiazine-4-carboxamide

Trypanosoma brucei

-

pH 7.5, temperature not specified in the publication

737319

0.194

N-(3-methylpiperazin-1-yl)-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.074

N-(4-((6,7-dimethoxyquinazolin-4-yl)amino)phenyl)-3-hydroxybenzamide

Mycobacterium tuberculosis

P9WMN3

pH 7.6, 37°C

741091

0.028

N-(4-[(6-nitroquinazolin-4-yl)amino]benzene-1-sulfonyl)acetamide

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.2

N-(5-methyl-1,3,4-thiadiazol-2-yl)-6-nitroquinazolin-4-amine

2 entries

0.0064

N-carbamimidoyl-4-[(6-nitroquinazolin-4-yl)-amino]benzene-1-sulfonamide

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.141

N-cyclohexyl-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.121

N-cyclopropyl-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.028

N-[4-[(6-nitroquinazolin-4-yl)amino]benzene-1-sulfonyl]acetamide

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.2

N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-6-nitroquinazolin-4-amine

2 entries

0.0108

N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0184

N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0134

N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0138

N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0154

N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0194

N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0112

N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0171

N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0233

N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.022

N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0125

N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0332

N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide

Xanthomonas oryzae pv. oryzae

-

pH 7.5, 37°C

741100

0.0104

N1-(6-nitroquinazolin-4-yl)benzene-1,2-diamine

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.0000063

rifampicin

Mycobacterium tuberculosis

P9WMN3

pH and temperature not specified in the publication

760857

0.2

4-methyl-7-[(6-nitroquinazolin-4-yl)amino]-2H-1-benzopyran-2-one

Mycobacterium tuberculosis

P9WMN3

above, pH and temperature not specified in the publication

760857

0.2

4-methyl-7-[(6-nitroquinazolin-4-yl)amino]-2H-1-benzopyran-2-one

Mycobacterium tuberculosis

P9WMN3

IC50 above 0.2 mM, pH and temperature not specified in the publication

760857

0.2

6-nitro-N-(5-phenyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

above, pH and temperature not specified in the publication

760857

0.2

6-nitro-N-(5-phenyl-1,3,4-thiadiazol-2-yl)quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

IC50 above 0.2 mM, pH and temperature not specified in the publication

760857

0.2

6-nitro-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

above, pH and temperature not specified in the publication

760857

0.2

6-nitro-N-[5-(4-methylphenyl)-1,3,4-thiadiazol-2-yl]quinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

IC50 above 0.2 mM, pH and temperature not specified in the publication

760857

0.2

N-(5-methyl-1,3,4-thiadiazol-2-yl)-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

above, pH and temperature not specified in the publication

760857

0.2

N-(5-methyl-1,3,4-thiadiazol-2-yl)-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

IC50 above 0.2 mM, pH and temperature not specified in the publication

760857

0.2

N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

above, pH and temperature not specified in the publication

760857

0.2

N-[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]-6-nitroquinazolin-4-amine

Mycobacterium tuberculosis

P9WMN3

IC50 above 0.2 mM, pH and temperature not specified in the publication

760857