2.4.1.B72: C-mannosyltransferase
This is an abbreviated version!
For detailed information about C-mannosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.B72
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2.4.1.B72
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c-mannosylation
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elegans
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thrombospondin
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neuroblast
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acrosome
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round-headed
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netrin
- 2.4.1.B72
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c-mannosylation
- elegans
- thrombospondin
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neuroblast
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acrosome
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round-headed
- netrin
Reaction
transfers a D-mannosyl residue from dolichyl D-mannosyl phosphate to the tryptophan residue of a protein acceptor forming a C-C bond =
Synonyms
C-mannosyltransferase, DPY-19, Dpy-19-like C-mannosyltransferase, Dpy-19-like protein 3, dpy19, DPY19L1, DPY19L3, DPY19L4, dumpy-19, Dumpy-19 protein homologue, Pf DPY-19, PF3D7_0806200, protein dpy-19 homolog 3, protein dumpy-19
ECTree
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Substrates Products
Substrates Products on EC 2.4.1.B72 - C-mannosyltransferase
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REACTION DIAGRAM
dolichyl D-mannosyl phosphate + ADAMTS-like 1
dolichyl phosphate + C-mannosylated ADAMTS-like 1
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purified recombinant tagged substrate. The substrate contains in thrombospondin type-1 repeats, two with predicted C-mannosylation sites, C-mannosylation of TSR1
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dolichyl D-mannosyl phosphate + human punctin-1
dolichyl phosphate + C-mannosylated human punctin-1
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purified recombinant tagged substrate. C-mannosylation at Trp39 and Trp42 of a thrombospondin type-1 repeat containing the 36WDAWGPWSECSRTC49 sequence, identified by Tandem mass spectrometry (MS/MS) and MS/MS/MS analysis, TSR1 from punctin-1 carries C-mannosylation in close proximity to O-linked fucose
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dolichyl D-mannosyl phosphate + MIG-21 protein
dolichyl phosphate + C-mannosylated MIG-21 protein
C-mannosylation at a tryptophan residue
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dolichyl D-mannosyl phosphate + UNC-5 protein
dolichyl phosphate + C-mannosylated UNC-5 protein
C-mannosylation at a tryptophan residue
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dolichyl D-mannosyl phosphate + WAKW
dolichyl phosphate + ?
in vitro assay using radiolabeled donor substrate and a synthetic acceptor peptide WAKW, which forms the minimal acceptor substrate
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C-mannosyl-UNC5A + GDP
C-mannosylation of murine UNC5A
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UNC5A + GDP-mannose
C-mannosyl-UNC5A + GDP
C-mannosylation of murine UNC5A, DPY19L1 can C-mannosylate the first two tryptophans in the WxxWxxWxxC sequence of UNC5A TSRs
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UNC5A + GDP-mannose
C-mannosyl-UNC5A + GDP
C-mannosylation of murine UNC5A, DPY19L3 mannosylates the third tryptophan of this sequence and might require a WxxC motif
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cell surface receptors MIG-21 and UNC-5 are acceptor substrates of enzyme DPY-19
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additional information
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cell surface receptors MIG-21 and UNC-5 are acceptor substrates of enzyme DPY-19
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additional information
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C-mannosylation of tryptophan residues is an endoplasmic reticulum localized, DPY-19 enzyme-catalyzed reaction using the lipid-linked glycoside dolichol-phosphate-mannose as the donor substrate
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additional information
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C-mannosylation of tryptophan residues is an endoplasmic reticulum localized, DPY-19 enzyme-catalyzed reaction using the lipid-linked glycoside dolichol-phosphate-mannose as the donor substrate
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additional information
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C-mannosylation is initially described as a modification of the first tryptophan in the WxxW consensus sequence, but is also observed on tryptophans that are not part of this motif. In addition to WxxW, WxxC is also considered to be a consensus sequence for C-mannosylation
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additional information
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C-mannosylation is initially described as a modification of the first tryptophan in the WxxW consensus sequence, but is also observed on tryptophans that are not part of this motif. In addition to WxxW, WxxC is also considered to be a consensus sequence for C-mannosylation
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additional information
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the enzyme can transfer mannose to adhesive thrombospondin type 1 repeats (TSRs) and type I cytokine receptors. Enzyme Dpy19 of Caenorhabditis elegans can transfer mannose to a short WXXW peptide
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additional information
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the enzyme can transfer mannose to adhesive thrombospondin type 1 repeats (TSRs) and type I cytokine receptors. Enzyme Dpy19 of Caenorhabditis elegans can transfer mannose to a short WXXW peptide
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additional information
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the single Caenorhabditis elegans C-mannosyltransferase DPY-19 mannosylates the first two tryptophans of a WxxWxxW motif
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additional information
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the single Caenorhabditis elegans C-mannosyltransferase DPY-19 mannosylates the first two tryptophans of a WxxWxxW motif
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additional information
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protein C-mannosylation is the attachment of alpha-mannopyranose to tryptophan via a C-C linkage. This post-translational modification typically occurs within the sequence motif WXXW, which is frequently present in thrombospondin type-1 repeats (TSRs). TSRs are especially numerous in and a defining feature of the ADAMTS superfamily. Predicted C-mannosylation sites in the ADAMTS superfamily, overview
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additional information
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analysis of C-mannosylation sites an substrate recognition, mutational analysis, mass spectroscopy, and metabolic labeling, overview
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additional information
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DPY19L3 is the C-mannosyltransferase of Rspo1 at residue W156
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additional information
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DPY19L3 is the C-mannosyltransferase of Rspo1 at residue W156
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additional information
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C-mannosylation of protein Rspo1, Rspo1 has two predicted C-mannosylation sites in the thrombospondin type 1 repeat TSR1, substrate structure, overview. Enzyme DPY19L3 selectively modified Rspo1 at residue W156 but not W153 based on mass spectrometry. Purified recombinant Rspo1 protein from the conditioned medium of overexpressing HT1080-Rspo1-MH cells
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additional information
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C-mannosylation of protein Rspo1, Rspo1 has two predicted C-mannosylation sites in the thrombospondin type 1 repeat TSR1, substrate structure, overview. Enzyme DPY19L3 selectively modified Rspo1 at residue W156 but not W153 based on mass spectrometry. Purified recombinant Rspo1 protein from the conditioned medium of overexpressing HT1080-Rspo1-MH cells
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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mammalian C-mannosyltransferases DPY19L1 and DPY19L3 do not have a dual WxxW/C recognition motif, but are active C-mannosyltransferases with distinct substrate specificities
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additional information
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no activity by DPY19L4 isozyme on murine UNC5A
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additional information
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no activity by DPY19L4 isozyme on murine UNC5A
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additional information
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no activity by DPY19L4 isozyme on murine UNC5A
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additional information
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no activity by DPY19L4 isozyme on murine UNC5A
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additional information
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the micronemal adhesin thrombospondin-related anonymous protein (TRAP) is C-hexosylated in Plasmodium falciparum sporozoites. When expressed in a mammalian cell line deficient in C-mannosylation, the Plasmodium falciparum Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide
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additional information
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the micronemal adhesin thrombospondin-related anonymous protein (TRAP) is C-hexosylated in Plasmodium falciparum sporozoites. When expressed in a mammalian cell line deficient in C-mannosylation, the Plasmodium falciparum Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide
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additional information
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several thrombospondin type 1 repeat (TSR) domain-containing proteins of Plasmodium falciparum can be C-mannosylated in vivo
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additional information
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several thrombospondin type 1 repeat (TSR) domain-containing proteins of Plasmodium falciparum can be C-mannosylated in vivo
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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additional information
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the micronemal protein MIC2 secreted by Toxoplasma gondii tachyzoites is C-hexosylated. When expressed in a mammalian cell line deficient in C-mannosylation, the Toxoplasma gondii Dpy19 homologue is able to modify TSR domains of the micronemal adhesins TRAP/MIC2 family involved in parasite motility and invasion. In vitro, the apicomplexan enzyme can transfer mannose to a WXXWXXC peptide but, in contrast to Caenorhabditis elegans or mammalian C-mannosyltransferases, is inactive on a short WXXW peptide. MIC2 secreted by Toxoplasma tachyzoites is C-mannosylated
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