2.3.1.B39: brefelding octaketide synthase
This is an abbreviated version!
For detailed information about brefelding octaketide synthase, go to the full flat file.
Word Map on EC 2.3.1.B39
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2.3.1.B39
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synthases
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iterative
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starter
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tetraketide
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enoyl
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phytotoxic
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megasynthase
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resorcylic
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polyene
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terreus
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diketide
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squalestatin
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n-acetylcysteamine
- 2.3.1.B39
- synthases
-
iterative
-
starter
-
tetraketide
-
enoyl
-
phytotoxic
-
megasynthase
-
resorcylic
-
polyene
- terreus
-
diketide
- squalestatin
- n-acetylcysteamine
Reaction
Synonyms
Bref-PKS, highly reducing polyketide synthase, HRPKS
ECTree
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6 | Substrates and Products (Substrate) |
6 | Synonyms |
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Natural Substrates Products
Natural Substrates Products on EC 2.3.1.B39 - brefelding octaketide synthase
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REACTION DIAGRAM
8 malonyl-CoA + 4 NADPH + 16 H+
8 CoA + (2E,4E,10E)-15-hydroxyhexadeca-2,4,10-trienoic acid + 8 CO2 + 4 NADP+ + 6 H2O
9 malonyl-CoA + 5 NADPH + 19 H+
9 CoA + (4E,6Z,12E)-17-hydroxyoctadeca-4,6,12-trienoic acid + 9 CO2 + 5 NADP+ + 7 H2O
8 CoA + (2E,4E,10E)-15-hydroxyhexadeca-2,4,10-trienoic acid + 8 CO2 + 4 NADP+ + 6 H2O
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main product in presence of thiohydrolase Bref-TH
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?
8 malonyl-CoA + 4 NADPH + 16 H+
8 CoA + (2E,4E,10E)-15-hydroxyhexadeca-2,4,10-trienoic acid + 8 CO2 + 4 NADP+ + 6 H2O
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main product in presence of thiohydrolase Bref-TH
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?
9 CoA + (4E,6Z,12E)-17-hydroxyoctadeca-4,6,12-trienoic acid + 9 CO2 + 5 NADP+ + 7 H2O
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-
main product in absence of thiohydrolase Bref-TH
-
?
9 malonyl-CoA + 5 NADPH + 19 H+
9 CoA + (4E,6Z,12E)-17-hydroxyoctadeca-4,6,12-trienoic acid + 9 CO2 + 5 NADP+ + 7 H2O
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main product in absence of thiohydrolase Bref-TH
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?
?
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enzyme shows an NADPH-dependent reductive tailoring specificity that leads to the synthesis of four different oktaketide products with varying degrees of reduction. Bref-PKS is a nonaketide synthase in the absence of an associated thiohydrolase Bref-TH
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-
?
additional information
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enzyme shows an NADPH-dependent reductive tailoring specificity that leads to the synthesis of four different oktaketide products with varying degrees of reduction. Bref-PKS is a nonaketide synthase in the absence of an associated thiohydrolase Bref-TH
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?