2.3.1.243: acyl-Kdo2-lipid IVA acyltransferase
This is an abbreviated version!
For detailed information about acyl-Kdo2-lipid IVA acyltransferase, go to the full flat file.
Reaction
Synonyms
ESA01386, Jhp0255, lauroyl-Kdo2-lipid IVA myristoyltransferase, lipid A biosynthesis myristoyltransferase, LpxJ, LpxL, LpxL2, LpxM, MsbB acyltransferase, myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA O-myristoyltransferase, tetradecanoyl-[acyl-carrier protein]:dodecanoyl-Kdo2-lipid IVA O-tetradecanoyltransferase
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Application
Application on EC 2.3.1.243 - acyl-Kdo2-lipid IVA acyltransferase
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drug development
mutants deleted either for the Braun lipoprotein genes lppA and lppB or in combination with the msbB gene, which encodes an acetyltransferase required for lipid A modification of lipopolysaccharide provided complete protection to immunized mice against a lethal oral challenge dose of wild type Salmonella typhimurium. These mutants may serve as excellent vaccine candidates and also provide a platform for delivering heterologous antigens
drug development
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mutants deleted either for the Braun lipoprotein genes lppA and lppB or in combination with the msbB gene, which encodes an acetyltransferase required for lipid A modification of lipopolysaccharide provided complete protection to immunized mice against a lethal oral challenge dose of wild type Salmonella typhimurium. These mutants may serve as excellent vaccine candidates and also provide a platform for delivering heterologous antigens
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