2.3.1.221: noranthrone synthase

This is an abbreviated version!
For detailed information about noranthrone synthase, go to the full flat file.

Word Map on EC 2.3.1.221

2.3.1.221

sporopollenin

tetraketide

exine

anther

microspore

tapetal

reductase1

halogenase

prenyltransferase

Reaction

7 malonyl-CoA +

= 7 CoA +

+ 7 CO2 + 2 H2O

Synonyms

norsolorinic acid anthrone synthase, norsolorinic acid anthrone-producing polyketide synthase, PksA, polyketide synthase A

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.221 noranthrone synthase

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Results	in table
6	AA Sequence
5	Cloned(Commentary)
1	Crystallization (Commentary)
13	General Information
2	kcat/KM [mM/s]
2	KM Value [mM]
4	Natural Substrates/ Products (Substrates)
7	Organism
6	Pathway
2	PDB ID
2	pH Optimum
7	Protein Variants
4	Purification (Commentary)
4	Reaction
6	Reference
2	Source Tissue
7	Substrates and Products (Substrate)
4	Subunits
9	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.3.1.221 - noranthrone synthase

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7 malonyl-CoA + acetyl-[acyl-carrier protein]

Aspergillus parasiticus

722459

7 malonyl-CoA + hexanoyl-[acyl-carrier protein]

7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O

3 entries

additional information

Aspergillus parasiticus

processivity of polyketide extension and substrate specificity, overview. The enzyme shows activity against hexanoyl- and acetyl-, but not malonyl-CoA. Rapid loading of extension units onto the carrier domain facilitates efficient chain extension in a manner kinetically favorable to ultimate product formation. Essential roles of the product template and thioesterase domains for cyclization and product release, editing role for the thioesterase domain

722459