2.1.1.69: 5-hydroxyfuranocoumarin 5-O-methyltransferase
This is an abbreviated version!
For detailed information about 5-hydroxyfuranocoumarin 5-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
bergaptol O-methyltransferase, bergaptol-5-O-methyltransferase, BMT, EC 2.1.1.92, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, methyltransferase, bergaptol
ECTree
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Engineering
Engineering on EC 2.1.1.69 - 5-hydroxyfuranocoumarin 5-O-methyltransferase
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I157F/V320I
the mutant shows about 4fold increased activity compared to the wild type enzyme
I157H
the mutant shows strongly reduced activity compared to the wild type enzyme
I157Y
the mutant shows about 2.4fold increased activity compared to the wild type enzyme
I157Y/S265F/V315N
the mutant shows severely reduced activity compared to the wild type enzyme
I157Y/S265N
the mutant shows about 1.5fold increased activity compared to the wild type enzyme
L122F
the mutant shows reduced activity compared to the wild type enzyme
L122H
the mutant shows severely reduced activity compared to the wild type enzyme
L122H/W261H
the mutant shows reduced severely activity compared to the wild type enzyme
L122H/W261H/H126F
the mutant shows severely reduced activity compared to the wild type enzyme
L122H/W261H/H126W
the mutant shows severely reduced activity compared to the wild type enzyme
S265I
the mutant shows about 2.5fold increased activity compared to the wild type enzyme
S265N
the mutant shows about 1.9fold increased activity compared to the wild type enzyme
V315F
the mutant shows severely reduced activity compared to the wild type enzyme
V320I
high-catalytic activity mutant with about 8.5fold increased activity compared to the wild type enzyme
V320Y
the mutant shows reduced activity compared to the wild type enzyme
W261H
the mutant shows about 1.9fold increased activity compared to the wild type enzyme
W261L
the mutant shows slightly reduced activity compared to the wild type enzyme
Y319F
the mutant shows about 5fold increased activity compared to the wild type enzyme