1.3.1.108: caffeoyl-CoA reductase

This is an abbreviated version!
For detailed information about caffeoyl-CoA reductase, go to the full flat file.

Word Map on EC 1.3.1.108

1.3.1.108

abasic

anteroposterior

apurinic

site-containing

2-amino-4-phosphonobutyrate

apyrimidinic

masker

acetabular

Reaction

+ 2 NAD⁺ + 2 reduced ferredoxin [iron-sulfur] cluster =

(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA

+ 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster

Synonyms

caffeoyl-CoA reductase-Etf complex, electron-bifurcating caffeoyl-CoA reductase, hydrocaffeoyl-CoA:NAD+, ferredoxin oxidoreductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.108 caffeoyl-CoA reductase

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525	AA Sequence
3	Cofactor
2	General Information
4	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
6	PDB ID
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
2	Reference
8	Substrates and Products (Substrate)
2	Subunits
6	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.3.1.108 - caffeoyl-CoA reductase

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3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD+, ferredoxin oxidoreductase

The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA.